Beth McGraw
Born
Elizabeth Ann McGraw
Alma materPennsylvania State University
University of Michigan
Scientific career
FieldsSymbiosis
Evolution
Vector:virus interactions
Wolbachia
InstitutionsMonash University
University of Queensland
Yale University
Pennsylvania State University
ThesisMolecular evolution of invasive bacterial pathogens (1998)
Websitewww.huck.psu.edu/people/elizabeth-mcgraw

Elizabeth Ann McGraw is an American biologist who is a professor in entomology at Pennsylvania State University.[1][2] She is the Director of the Center for Infectious Disease Dynamics and a Huck Scholar in Entomology. Her research investigates the bacterium Wolbachia as a strategy for biocontrol and to better understand the basis of its interactions with insects.[3][4][5] She was elected a Fellow of the American Society for Microbiology.

Early life and education

McGraw was an undergraduate biology student at the University of Michigan. She moved to Pennsylvania State University where she studied the evolution of virulence genes in human pathogens and was awarded a PhD in 1998.[6]

Research and career

After her PhD, she joined Yale University for her postdoctoral research, where she studied the Wolbachia insect system. She was particularly interested in being able to ask questions about the evolution of mutualism. She moved to the University of Queensland as a postdoctoral researcher.

McGraw was appointed to the faculty at the University of Queensland, then moved to Monash University as a Larkins Fellow in 2011, where she studied how bacteria affect host biology and how insects invest in response to a symbiont.[7] She has extensively studied the endosymbiont Wolbachia. Wolbachia prevents harmful pathogens replicating inside mosquitos, which may offer hope for biocontrol against mosquito-borne diseases.[8] Her research showed that when Wolbachia was inside mosquitoes it could prevent viruses from replicating.[9] She showed that Dengue virus could not become resistant to Wolbachia, and that Dengue viruses grown with Wolbachia were less effective at infecting mosquito cells and were less able to replicate.[9][10]

In 2017, McGraw joined Pennsylvania State University as a professor in entomology.[11]

Awards and honors

McGraw was elected Fellow of the American Society for Microbiology in 2023.[8]

Selected publications

  • A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium[3]
  • Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission[4]
  • Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements[5]

References

  1. ↑ Elizabeth McGraw publications indexed by Google Scholar
  2. ↑ Elizabeth McGraw publications from Europe PubMed Central
  3. 1 2 Luciano A Moreira; Iñaki Iturbe-Ormaetxe; Jason A Jeffery; et al. (1 December 2009). "A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium". Cell. 139 (7): 1268–1278. doi:10.1016/J.CELL.2009.11.042. ISSN 0092-8674. PMID 20064373. Wikidata Q29616261.
  4. 1 2 Hoffmann AA; Montgomery BL; Popovici J; et al. (24 August 2011). "Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission". Nature. 476 (7361): 454–7. doi:10.1038/NATURE10356. ISSN 1476-4687. PMID 21866160. Wikidata Q29615114.
  5. 1 2 Martin Wu; Ling V Sun; Jessica Vamathevan; et al. (March 2004). "Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements". PLOS Biology. 2 (3): E69. doi:10.1371/JOURNAL.PBIO.0020069. ISSN 1544-9173. PMC 368164. PMID 15024419. Wikidata Q21563646.
  6. ↑ McGraw, Elizabeth Ann (1998). Molecular evolution of invasive bacterial pathogens (PhD thesis). Pennsylvania State University. OCLC 299248804. ProQuest 304463293.
  7. ↑ "Professor Elizabeth McGraw". zoo.ox.ac.uk. Retrieved 2023-02-28.
  8. 1 2 "McGraw elected as a Fellow of the American Academy of Microbiology | Penn State University". psu.edu. Retrieved 2023-02-28.
  9. 1 2 "Combating mosquito-borne diseases with bacteria | Penn State University". psu.edu. Retrieved 2023-02-28.
  10. ↑ "Global warming may limit spread of dengue fever, new research finds | Penn State University". psu.edu. Retrieved 2023-02-28.
  11. ↑ "People". vectorbiologygroup.com. Retrieved 2023-02-28.
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