EcpR1 (elongated cell phenotype RNA1) is a trans-encoded small non-coding RNA in the plant-symbiotic Sinorhizobium meliloti, previously named SmelC291, SmrC10, or Sra33.[1][2][3] According to its overproduction phenotype it was renamed Elongated Cell Phenotype RNA1.[4] Induced by stress, EcpR1 negatively regulates cell cycle master regulatory genes dnaA and gcrA at post-transcriptional level by base pairing between its strongly conserved GC-rich loop and the target mRNAs. It is suggested that EcpR1 connects stress adaptation and cell cycle progression.[4]

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Further reading

  1. ↑ Schlüter JP, Reinkensmeier J, Daschkey S, Evguenieva-Hackenberg E, Janssen S, Jänicke S, Becker JD, Giegerich R, Becker A (April 2010). "A genome-wide survey of sRNAs in the symbiotic nitrogen-fixing alpha-proteobacterium Sinorhizobium meliloti". BMC Genomics. 11: 245. doi:10.1186/1471-2164-11-245. PMC 2873474. PMID 20398411.
  2. ↑ Reinkensmeier J, Schlüter JP, Giegerich R, Becker A (November 2011). "Conservation and Occurrence of Trans-Encoded sRNAs in the Rhizobiales". Genes. 2 (4): 925–956. doi:10.3390/genes2040925. PMC 3927594. PMID 24710299.
  3. ↑ del Val C, Rivas E, Torres-Quesada O, Toro N, Jiménez-Zurdo JI (December 2007). "Identification of differentially expressed small non-coding RNAs in the legume endosymbiont Sinorhizobium meliloti by comparative genomics". Molecular Microbiology. 66 (5): 1080–1091. doi:10.1111/j.1365-2958.2007.05978.x. PMC 2780559. PMID 17971083.
  4. 1 2 Robledo M, Frage B, Wright PR, Becker A (April 2015). "A stress-induced small RNA modulates alpha-rhizobial cell cycle progression". PLOS Genetics. 11 (4): e1005153. doi:10.1371/journal.pgen.1005153. PMC 4414408. PMID 25923724.
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