Dreyfuss is a surname; notable people with this surname include:
- Barney Dreyfuss (1865–1932), baseball entrepreneur, co-founder of the World Series
- Gideon Dreyfuss, molecular biologist, Howard Hughes Medical Institute and University of Pennsylvania
- Henry Dreyfuss (1904–1972), industrial designer
- Joel Dreyfuss (born 1945), editor-in-chief of Red Herring
- Richard Dreyfuss (born 1947), American actor
- Robert Dreyfuss, American freelance investigative journalist
- Rochelle C. Dreyfuss, American law professor
See also
- Dreyfus (disambiguation), Dreyfus (surname)
- Dreifuss
- Orvil Dryfoos (1912–1963), publisher of The New York Times from 1961 to 1963
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