Dreifuss is a surname. Notable people with the surname include:
- Arthur Dreifuss (1908–1993), American film director
- Fritz E. Dreifuss (1926–1997), American neurologist
- Ruth Dreifuss (born 1940), Swiss politician
See also
- Dryfoos (surname)
- Dreyfus (disambiguation)
- Dreyfuss
- Claudia Dreifus, American journalist
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