Dhori thogotovirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Insthoviricetes
Order: Articulavirales
Family: Orthomyxoviridae
Genus: Thogotovirus
Species:
Dhori thogotovirus
Serotypes

Batken virus
Dhori virus

Dhori virus (DHOV) is a species of the genus Thogotovirus and a member of the family Orthomyxoviridae. Its host is most commonly Ixodidae ticks[1] but can also be other species of ticks, mosquitoes, and mammals (including humans). DHOV is lethal to mice, leads to high rates of miscarriages in sheep and goats,[1] and causes systemic pathologic changes similar to those reported in humans with virulent influenza A (H5N1) virus infection.[2]

Batken virus (BKNV) is considered a subtype of DHOV. Serological cross-reactions between BKNV and DHOV indicate a phylogenetic relationship between these viruses.[3]

Additionally, in 2014 Bourbon virus (BRBV) was found to be phylogenetically related to DHOV. [4]

References

  1. 1 2 Lledó, Lourdes; Giménez-Pardo, Consuelo; Gegúndez, María Isabel (2020). "Epidemiological Study of Thogoto and Dhori Virus Infection in People Bitten by Ticks, and in Sheep, in an Area of Northern Spain". International Journal of Environmental Research and Public Health. 17 (7): 2254. doi:10.3390/ijerph17072254. ISSN 1660-4601. PMC 7177830. PMID 32230796.
  2. ↑ Li G, Wang N, Guzman H, Sbrana E, Yoshikawa T, Tseng CT, Tesh RB, Xiao SY (2008). "Dhori virus (Orthomyxoviridae: Thogotovirus) infection of mice produces a disease and cytokine response pattern similar to that of highly virulent influenza A (H5N1) virus infection in humans". Am. J. Trop. Med. Hyg. 78 (4): 675–80. doi:10.4269/ajtmh.2008.78.675. PMID 18385368.
  3. ↑ Frese M, Weeber M, Weber F, Speth V, Haller O (1997). "Mx1 sensitivity: Batken virus is an orthomyxovirus closely related to Dhori virus". J. Gen. Virol. 78 ( Pt 10) (10): 2453–8. doi:10.1099/0022-1317-78-10-2453. PMID 9349464.
  4. ↑ Roe, Molly K.; Huffman, Elise R.; Batista, Yara S.; Papadeas, George G.; Kastelitz, Sydney R.; Restivo, Anna M.; Stobart, Christopher C. (2023). "Comprehensive Review of Emergence and Virology of Tickborne Bourbon Virus in the United States - Volume 29, Number 1—January 2023 - Emerging Infectious Diseases journal - CDC". Emerging Infectious Diseases. 29 (1): 1–7. doi:10.3201/eid2901.212295. PMC 9796205. PMID 36573641.
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