de Soto is a Spanish surname. Notable people with the surname include:
- Alexander de Soto (1840–1936), Spanish American physician, businessman, and philanthropist
- Álvaro de Soto (born 1943), Peruvian diplomat and UN special envoy
- Domingo de Soto (1494–1560), Spanish theologian
- Ernest de Soto (1923 – 2014), American master printmaker and lithographer.
- Francisco de Soto (c. 1500–1563), Spanish organist and composer
- Hernando de Soto (c. 1496/1497–1542), Spanish conquistador
- Hernando de Soto Polar (born 1941), Peruvian economist and author
- Jesús Huerta de Soto (born 1956), economist of the Austrian school, born in Spain
- Luis Barahona de Soto (1548–1595), Spanish poet
- Pedro de Soto (1493–1563), Spanish theologian
- Benito de Soto (1805–1830), pirate
- Ernestine Ygnacio-De Soto, sometimes written as Ernestine Ygnacio De Soto, Barbareño Chumash activist and historian.
Surnames associated with the occupations of cobbler / shoemaker / cordwainer | ||
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| Celtic |  | |
| Germanic |
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| Romance |
Ciubotaru, Ciubotariu (borrowing from Slavic) | |
| Slavic |
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| Other | ||
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