DDT (gene)

DDT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Q3F, 3KAN, 1DPT
Identifiers
Aliases	DDT, DDCT, D-dopachrome tautomerase, MIF-2, MIF2, D-DT
External IDs	OMIM: 602750 MGI: 1298381 HomoloGene: 1038 GeneCards: DDT
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,979,828 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,609,248 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; kidney; ; body of stomach; ; left ventricle; ; fundus; ; right adrenal gland; ; duodenum; ; left adrenal gland; ; substantia nigra;
	Top expressed in
	proximal tubule; ; spermatocyte; ; yolk sac; ; kidney; ; testicle; ; white adipose tissue; ; liver; ; adrenal gland; ; pancreas; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dopachrome isomerase activity; D-dopachrome decarboxylase activity; lyase activity; cytokine receptor binding; phenylpyruvate tautomerase activity;
Cellular component	cytoplasm; extracellular exosome; extracellular space;
Biological process	melanin biosynthetic process; negative regulation of macrophage chemotaxis; positive regulation of tumor necrosis factor production; positive regulation of inflammatory response; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	1652
	13202
	ENSG00000099977; ENSG00000275003
	ENSMUSG00000001666
	P30046
	O35215
	NM_001084392; NM_001355; NM_001381852; NM_001397485
	NM_010027
	NP_001077861; NP_001346; NP_001368781
	NP_034157
	Wikidata
View/Edit Human	View/Edit Mouse

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.^[5]^[6]^[7]

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.^[7]

References

1 2 3 ENSG00000275003 GRCh38: Ensembl release 89: ENSG00000099977, ENSG00000275003 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001666 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844.
↑ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3) (3): 617–23. doi:10.1042/bj3340617. PMC 1219731. PMID 9729470.
1 2 "Entrez Gene: DDT D-dopachrome tautomerase".

Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. S2CID 23518983.
Odh G, Hindemith A, Rosengren AM, et al. (1994). "Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole". Biochem. Biophys. Res. Commun. 197 (2): 619–24. doi:10.1006/bbrc.1993.2524. PMID 8267597.
Esumi N, Budarf M, Ciccarelli L, et al. (1999). "Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF". Mamm. Genome. 9 (9): 753–7. doi:10.1007/s003359900858. PMID 9716662. S2CID 24034990.
Sugimoto H, Taniguchi M, Nakagawa A, et al. (1999). "Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution". Biochemistry. 38 (11): 3268–79. doi:10.1021/bi982184o. PMID 10079069.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Lubetsky JB, Dios A, Han J, et al. (2002). "The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents". J. Biol. Chem. 277 (28): 24976–82. doi:10.1074/jbc.M203220200. PMID 11997397.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Sonesson B, Rosengren E, Hansson AS, Hansson C (2004). "UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor". Exp. Dermatol. 12 (3): 278–82. doi:10.1034/j.1600-0625.2003.120307.x. PMID 12823441. S2CID 12494872.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000275003 GRCh38: Ensembl release 89: ENSG00000099977, ENSG00000275003 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001666 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9480844-5] Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844.

[pmid9729470-6] Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3) (3): 617–23. doi:10.1042/bj3340617. PMC 1219731. PMID 9729470.

[entrez-7] 1 2 "Entrez Gene: DDT D-dopachrome tautomerase".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

See also

References

Further reading