The team reopens the 1973 murder of Mike "Bad Moon" McShane, a 21-year-old college football player, when an old friend of Jeffries brings evidence that the crime may have occurred later than originally thought. The team soon discovers the victim may have been murdered before he could reveal some shady dealings going on within the team.

The team reopens the 1991 murder of Laura McKinney, a 22-year-old inner-city schoolteacher, thought to have been killed in a car jacking gone wrong, when her car keys are discovered in an old desk at her high school. The investigation leads them to her class of rowdy, underachieving students, one of whom that could know the truth of that night.

• This episode appears to be based on Bel Kaufman's Up the Down Staircase.
• Song featured in the intro: "Right Here, Right Now", by Jesus Jones.
• Song featured in the finale: "Half a World Away", by R.E.M.
• Based on Freedom Writers.

The team investigates the 1964 death of Miriam Forrester, a door-to-door Tupperware saleswoman thought to have been killed in an accident when her sister brings new evidence that she was actually murdered. They soon discover that she was part of a group called "Wednesday's Women" who used Tupperware sales as a cover to travel to Mississippi during Freedom Summer and help disadvantaged African-American schoolchildren, much to the ire of white southerners.

The team reinvestigates the 1978 murder of Missy Gallavan, a 15-year-old roller skater who was found in a ravine, when a convicted thief reveals some information regarding her death in order to get a lighter sentence.

When human remains and dog tags are found inside an old oil barrel, the team investigates the disappearance of Jimmy Tulley, a 17-year-old Marine who was reported AWOL on his last night of shore leave in 1951.

The team investigates the 1981 case of Donna D'Amico, a missing 22-year-old single mother, after her body is found in the trunk of a car and soon discover that she may have been growing wise to the shady chop shop operations at the car dealership where she had worked.

After a toy rocket is given to a former homicide detective, the team reinvestigates the murder of its owner Danny Finch, a 12-year-old boy whose body was found in a river on the day after the Apollo 11 landing in 1969. But when one of the victim's childhood friends commits suicide while left alone in interrogation, the team must figure out what happened at the creek and who was responsible for the boy's death.

Nick and the team reexamines the 1989 murder of Nadia Koslov, an 18-year-old Russian opera singer who emigrated from the former Soviet Union with her family, when her brother recovers her long-lost bag from a stranger on the street. It is found out that the Koslovs were helped by a young Nick Vera back then when he was a rookie, as well as the discovery that the victim had been poisoned just before her death.

The 1953 murder of Rita Flynn, a famous 26-year-old pin-up model, is reinvestigated by the team when a fan brings in a one-of-a-kind photograph that reveals more details about the night of her death.

When an inmate exchanges some procured information on an old shooting, the team reopens the 2005 murder of Dexter Collins, a 30-year-old African-American politician who vowed to rid the lower-class neighborhood he grew up in of drug dealers who preyed on young kids.

The 1960 disappearance of Ally Thurston, a 21-year-old flight attendant who was trying to unionize her coworkers to battle the sexist work area of the flight industry, is reopened after her remains are found in the rubble of a demolished Philadelphia hotel.

The detectives reinvestigate the 2007 murder of Ed Dubinski, a 34-year-old auto mechanic whose lottery winnings earned him a number of fair-weather friends, when it is found that his bank account had recently been accessed.

• Song featured in the intro: "The Underdog", by Spoon.
• Song featured in the finale: "On the Way Back Home", by Lucero.

The team reopens the 1988 murder of Jane Everett, a 27-year-old Philadelphia news anchor. They soon learn that she was working on a big story involving a local factory's deadly working conditions shortly before her death.

• Song featured in the intro: "Simply Irresistible", by Robert Palmer.
• Song featured in the finale: "Shout", by Tears for Fears.
• This episode has similarities to the 1983 attempted robbery and attempted murder of Los Angeles anchor Jerry Dunphy.
• In the intro, Jane Everett mentions the ending of the 1988 Writer's strike and the return of CBS shows Murder, She Wrote and Falcon Crest; however, the 1988-89 television season premiered their scripted shows between October and December.
• WCNU is not a real TV station but was a defunct radio station that was based in Crestview, Florida.

When remains are found at the bottom of a drained duck pond, the team reopens the 1967 murder of Roy Dunn, an enigmatic 35-year-old door-to-door salesman who was popular with the neighborhood residents. The team soon uncovers some troubling secrets in the neighborhood he was last seen at and wonder if he saw something that may have gotten him killed.

• Song featured in the intro: "I'll Be Your Mirror", by the Velvet Underground.
• Song featured in the finale: "Pale Blue Eyes", by the Velvet Underground.

The team opens the 2008 case of Ben Feldman, a man who was murdered while in the witness protection program, when his widow comes to the police asking for help in looking for their missing son, who might be looking for the killer/killers who murdered his father for revenge.

• There was no song featured in the intro.
• Song featured in the finale: "Until the Day Is Done", by R.E.M.

The team reopens the case of Sarah Blake, a 17-year-old-girl who was murdered in 1976, when her father finds evidence suggesting that she had become involved with a notorious motorcycle gang shortly before her death.

• Song featured in the intro: "Magic Man", by Heart.
• Song featured in the finale: "Simple Man", by Lynyrd Skynyrd.

When Jeffries is wounded and another man, Henry "Pop" Walters, is killed during a robbery at a convenience store, the rest of the team must race against time to track down the shooter before the trail goes cold. This episode depicts a lower-class neighborhood, gang activities and the hard life of minorities.

• This is easily the newest case featured on the series to date.
• Song featured in the intro: "I Wish It Would Rain", by The Temptations
• Song featured in the finale: "The Judgment", by Solomon Burke
• Detective Will Jefferies is seen in the hospital for the rest of the episode leaving viewers to wonder if he was going to survive which he did and was using a cane for a few episodes as a result of being shot.

The team reopen the 2004 case of Julie Ramirez, a psychiatrist who died in a suspicious fire, after the former roommate of one her patients finds a notebook detailing the fire. The case proves rather hard to solve as the patient has had severe schizophrenia for years.

• All the music featured in this episode is performed by John Lennon.
• Song featured in the intro: "Beautiful Boy (Darling Boy)", by John Lennon
• Song featured in the finale: "Watching the Wheels", by John Lennon

The team re-investigates the 1958 murder of Julian Bellowes, a newlywed real estate developer who was spearheading a new suburban concept, when new evidence suggests his body might have been moved after he was killed. The case is turned upside down however, when they learn a dark secret the victim had been keeping for a long time.

• Song featured in the intro: "Are You Havin' Any Fun?", by Tony Bennett
• Song featured in the finale: "This Land Is Your Land", by Sharon Jones & the Dap-Kings

The team investigates the 1999 murder of Gonzalo Luque, a 23-year-old Cuban immigrant who arrived in Philadelphia on a small boat with others and was pursuing a major league baseball career, after an illegal immigrant hoping to stay in the country says he saw the victim's body in another location.

• Song featured in the intro: "537 C.U.B.A.", by Orishas
• Song featured in the finale: "Vida Mas Simple" by Nil Lara.
• This episode has similarities to Elian Gonzalez, the Cuban boy who along with his mother and 12 other immigrants tried to travel to Florida from Cuba on a small boat.

When the murder weapon from a 1963 case is unearthed, the team reopens the murder of Patrick "The Rifle" Lennox, a pool hustler who was shot the same day President John F. Kennedy was assassinated. The investigation reveals the victim might've grown weary of the hustling business.

• This has similarities to the movie The Hustler.
• Song featured in the intro: "Green Onions", by Booker T. & the M.G.'s.
• Song featured in the finale: "My One and Only Love" by John Coltrane.

In the first part of the two-part season finale, the team reopens the case of the first ever female cadet, 18-year-old Kate Butler, at a local military academy who was murdered in 2005 after her body is found in an unmarked grave at a military cemetery.

• All the music featured in this episode is performed by Pearl Jam.
• Song featured in the intro: "Corduroy", by Pearl Jam.
• Song featured in the finale: "Yellow Ledbetter" by Pearl Jam.
• Last appearance of Tania Raymonde as Frankie Rafferty.
• At the end of this episode, a truck runs Detective Lilly Rush off the road and into a river leaving viewers to wait until the next week to see if she gets out of her flooded car and out of the river.

In the second part of the finale, the investigation into 18-year-old Kate Butler's murder continues. Lilly, impatient to get back to the case, leaves the hospital before her tests are complete. As the team finds more and more clues, the killer tries to stop the investigation in order to remain hidden.

• All the music featured in this episode is performed by Pearl Jam.
• Song featured in the intro: "Once", by Pearl Jam.
• Song featured in the finale: "Black" by Pearl Jam.
• Throughout the episode, Detective Lilly Rush has flashbacks from her past ranging from her childhood to her days as a police officer, the day Lt. John Stillman chose her for homicide after passing her detective exam, and her car accident as she is still feeling dizzy and at the end of the episode, we see her being carried to an ambulance leaving viewers to wait until the first episode of season 7 to see if she fully recovers from the accident.