CTSW
Identifiers
AliasesCTSW, LYPN, cathepsin W
External IDsOMIM: 602364 MGI: 1338045 HomoloGene: 37471 GeneCards: CTSW
Orthologs
SpeciesHumanMouse
Entrez

1521

13041

Ensembl

ENSG00000172543

ENSMUSG00000024910

UniProt

P56202

P56203

RefSeq (mRNA)

NM_001335

NM_009985

RefSeq (protein)

NP_001326

NP_034115

Location (UCSC)Chr 11: 65.88 – 65.88 MbChr 19: 5.52 – 5.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cathepsin W is a protein that in humans is encoded by the CTSW gene.[5][6][7]

The protein encoded by this gene, a member of the peptidase C1 family of cysteine cathepsins, is a cysteine protease cathepsin that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the cell membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024910 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Linnevers C, Smeekens SP, Brömme D (May 1997). "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes". FEBS Lett. 405 (3): 253–9. doi:10.1016/S0014-5793(97)00118-X. PMID 9108299. S2CID 45420314.
  6. Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D (Aug 1998). "Genomic structure, chromosomal localization, and expression of human cathepsin W". Biochem Biophys Res Commun. 248 (2): 255–61. doi:10.1006/bbrc.1998.8954. PMID 9675123.
  7. 1 2 "Entrez Gene: CTSW cathepsin W".

Further reading

  • The MEROPS online database for peptidases and their inhibitors: C01.037


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