CLASP2

CLASP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WOY
Identifiers
Aliases	CLASP2, cytoplasmic linker associated protein 2
External IDs	OMIM: 605853 MGI: 1923749 HomoloGene: 24944 GeneCards: CLASP2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	33,718,356 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	113,919,682 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; middle frontal gyrus; ; Brodmann area 10; ; frontal pole; ; endothelial cell; ; ganglionic eminence; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; postcentral gyrus; ; superior vestibular nucleus;
	Top expressed in
	lateral geniculate nucleus; ; inferior colliculus; ; medial geniculate nucleus; ; pineal gland; ; mammillary body; ; superior colliculus; ; medial dorsal nucleus; ; cerebellar vermis; ; globus pallidus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein tyrosine kinase binding; dystroglycan binding; microtubule binding; microtubule plus-end binding; actin filament binding; protein binding; kinetochore binding;
Cellular component	cytoplasm; Golgi apparatus; cell projection; kinetochore microtubule; membrane; focal adhesion; plasma membrane; axonal growth cone; spindle; microtubule organizing center; chromosome; ruffle membrane; trans-Golgi network; cell cortex; cell leading edge; cortical microtubule plus-end; cytoplasmic microtubule; mitotic spindle; basal cortex; microtubule; chromosome, centromeric region; cytoskeleton; kinetochore; cytosol;
Biological process	vesicle targeting; regulation of actin cytoskeleton organization; regulation of axon extension; Golgi organization; mitotic spindle organization; regulation of epithelial to mesenchymal transition; positive regulation of epithelial cell migration; exit from mitosis; cell division; establishment or maintenance of cell polarity; positive regulation of extracellular matrix disassembly; positive regulation of basement membrane assembly involved in embryonic body morphogenesis; negative regulation of microtubule depolymerization; microtubule anchoring; regulation of microtubule-based process; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; negative regulation of wound healing, spreading of epidermal cells; cell cycle; positive regulation of exocytosis; negative regulation of stress fiber assembly; microtubule organizing center organization; negative regulation of focal adhesion assembly; regulation of gastrulation; microtubule cytoskeleton organization; microtubule nucleation; platelet-derived growth factor receptor-beta signaling pathway; sister chromatid cohesion; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	23122
	76499
	ENSG00000163539
	ENSMUSG00000033392
	O75122
	Q8BRT1
NM_001207044; NM_015097; NM_001365627; NM_001365628; NM_001365629;
	NM_001365630; NM_001365631; NM_001365632; NM_001365633; NM_001365634; NM_001375694; NM_001375697; NM_001375700; NM_001375701; NM_001375703; NM_001375705; NM_001375713; NM_001375715; NM_001375716; NM_001375718; NM_001375720
NM_001081960; NM_001114347; NM_001286599; NM_001286600; NM_001286601;
	NM_001286602; NM_001286603; NM_029633
NP_001193973; NP_055912; NP_001352556; NP_001352557; NP_001352558;
	NP_001352559; NP_001352560; NP_001352561; NP_001352562; NP_001352563; NP_001362623; NP_001362626; NP_001362629; NP_001362630; NP_001362632; NP_001362634; NP_001362642; NP_001362644; NP_001362645; NP_001362647; NP_001362649
NP_001075429; NP_001107819; NP_001273528; NP_001273529; NP_001273530;
	NP_001273531; NP_001273532; NP_083909
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163539 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033392 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CLASP2 cytoplasmic linker associated protein 2".

External links

Human CLASP2 genome location and CLASP2 gene details page in the UCSC Genome Browser.

Galjart N (2005). "CLIPs and CLASPs and cellular dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712. S2CID 23216754.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Lemos CL, Sampaio P, Maiato H, et al. (2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization". EMBO J. 19 (14): 3668–82. doi:10.1093/emboj/19.14.3668. PMC 313969. PMID 10899121.
Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329. S2CID 14443149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Maiato H, Fairley EA, Rieder CL, et al. (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. hdl:10216/53832. PMID 12837247. S2CID 13936836.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lee H, Engel U, Rusch J, et al. (2004). "The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance". Neuron. 42 (6): 913–26. doi:10.1016/j.neuron.2004.05.020. PMID 15207236.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
Wittmann T, Waterman-Storer CM (2005). "Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells". J. Cell Biol. 169 (6): 929–39. doi:10.1083/jcb.200412114. PMC 2171640. PMID 15955847.
Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
Mimori-Kiyosue Y, Grigoriev I, Sasaki H, et al. (2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment". Genes Cells. 11 (8): 845–57. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869. S2CID 33744175.
Pereira AL, Pereira AJ, Maia AR, et al. (2007). "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function" (PDF). Mol. Biol. Cell. 17 (10): 4526–42. doi:10.1091/mbc.E06-07-0579. PMC 1635371. PMID 16914514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163539 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033392 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLASP2 cytoplasmic linker associated protein 2".

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References

External links

Further reading