Big Mike is a nickname of:
People with the nickname
- Stormzy (born 1993), British grime artist and rapper
- Mike Abrams (criminal) (died 1898), American underworld criminal
- Michael Clemente (1908-1987), American mobster
- Michael Clarke Duncan (1957-2012), American actor sometimes credited as "Big Mike" Duncan
- Michael Elgin (born 1986), Canadian professional wrestler
- Mike Holmes, Canadian contractor-builder and TV personality
- Michael Hossack (1946–2012), American drummer for the band The Doobie Brothers
- Michael Lynche (born 1983), American singer and American Idol contestant
- Mike Mahoney (first baseman) (1873-1940), American baseball player
- Michele Miranda (1896-1973), American mobster
- Michael Oher (born 1986), American National Football League player
- Michael Sarno (born 1958), American mobster
- Black Mike Winage (1870-1977), Serbian-Canadian miner, pioneer and adventurer, known early on as "Big Mike"
Fictional characters
- Big Mike (Chuck), in the American television series Chuck
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