BABAM2
Identifiers
AliasesBABAM2, BRCC4, BRCC45, BRE, brain and reproductive organ-expressed (TNFRSF1A modulator), BRISC and BRCA1 A complex member 2
External IDsOMIM: 610497 MGI: 1333875 HomoloGene: 3604 GeneCards: BABAM2
Orthologs
SpeciesHumanMouse
Entrez

9577

107976

Ensembl

ENSG00000158019

ENSMUSG00000052139

UniProt

Q9NXR7

Q8K3W0

RefSeq (mRNA)

NM_144541
NM_181279
NM_181280
NM_181281
NM_181282

RefSeq (protein)

NP_653124
NP_851796
NP_851797
NP_851798
NP_851799

Location (UCSC)Chr 2: 27.89 – 28.34 MbChr 5: 31.86 – 32.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.[5][6][7]

Repair of DNA damage

BRE, the protein product of the BRE (gene), is a core component of the deubiquitin complex BRCA1-A.[8] Other core components of the BRCA1-A complex are the BRCC36 protein (BRCC3 gene), MERIT40 protein (BABAM1 gene), and RAP80 protein (UIMC1 gene).[8]

BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks. Sequestration of BRCA1 away from the DNA damage site suppresses homologous recombination and redirects the cell in the direction of repair by the process of non-homologous end joining (NHEJ).[8] The role of BRCA1-A appears to be to bind BRCA1 with high affinity and withdraw it away from the site of DNA damage to the periphery where it remains sequestered, thus promoting NHEJ in preference to HR.

Protein-protein interactions

BRE (gene) has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000158019 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052139 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Gu C, Castellino A, Chan JY, Chao MV (September 1998). "BRE: a modulator of TNF-alpha action". FASEB Journal. 12 (12): 1101–1108. doi:10.1096/fasebj.12.12.1101. PMID 9737713. S2CID 83491319.
  6. ↑ Li L, Yoo H, Becker FF, Ali-Osman F, Chan JY (January 1995). "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid". Biochemical and Biophysical Research Communications. 206 (2): 764–774. doi:10.1006/bbrc.1995.1108. PMID 7826398.
  7. ↑ "Entrez Gene: BRE brain and reproductive organ-expressed (TNFRSF1A modulator)".
  8. 1 2 3 Rabl J (October 2020). "BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling". Biomolecules. 10 (11): 1503. doi:10.3390/biom10111503. PMC 7692841. PMID 33142801.
  9. 1 2 3 4 5 6 Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R (November 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell. 12 (5): 1087–1099. doi:10.1016/s1097-2765(03)00424-6. PMID 14636569.
  10. 1 2 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  11. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading


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