Atopobium
Scientific classification
Domain:
Bacteria
Phylum:
Actinomycetota
Class:
Coriobacteriia
Order:
Coriobacteriales
Family:
Atopobiaceae
Genus:
Atopobium

Collins and Wallbanks 1993
Type species
Atopobium minutum
(Hauduroy et al. 1937) Collins & Wallbanks 1993
Species[1]
  • A. deltae
  • "A. detroiti" Salimnia et al. 2008
  • A. fossor
  • "A. massiliense" Bordigoni et al. 2020
  • A. minutum

Atopobium is a genus of Actinomycetota, in the family Coriobacteriaceae. Atopobium species are anaerobic, Gram-positive rod-shaped or elliptical bacteria found as single elements or in pairs or short chains.

Atopobium vaginae was discovered in 1999.[2] This is a facultative anaerobic bacteria, which form small colonies on blood agar at 37 °C is also positive for acid phosphatase. This species has now been reclassified into the genus Fannyhessea following phylogenetic studies.

Clinical significance

The genus Atopobium may be associated with bacterial vaginosis.[3][4][5]

The genus may play a role in the development of Colorectal cancer. While the genus has been reported as overrepresented in feces of patients,[6] A. minutum has conversely shown a mild apoptotic effect on cancer cells in vitro and has been suggested to be comparable to probiotic bacteria in regards to colorectal cancer.[7]


Phylogeny

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)[8] and National Center for Biotechnology Information (NCBI).[9]

16S rRNA based LTP_08_2023[10][11][12] and 120 marker proteins based GTDB 08-RS214[13][14][15]
Atopobium

A. deltae Cools et al. 2014

A. fossor (Bailey and Love 1986) Kageyama et al. 1999

A. minutum (Hauduroy et al. 1937) Collins and Wallbanks 1993

See also

References

  1. ↑ LPSN lpsn.dsmz.de
  2. ↑ Rodriguez Jovita M, Collins MD, Sjödén B, Falsen E (1999). "Characterization of a novel Atopobium isolate from the human vagina: description of Atopobium vaginae sp. nov". Int J Syst Bacteriol. 49 (4): 1573–6. doi:10.1099/00207713-49-4-1573. PMID 10555338.
  3. ↑ Verhelst R, Verstraelen H, Claeys G, Verschraegen G, Delanghe J, Van Simaey L, De Ganck C, Temmerman M, Vaneechoutte M (Apr 21, 2004). "Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis". BMC Microbiol. 4 (16): 1573–6. doi:10.1186/1471-2180-4-16. PMC 419343. PMID 15102329.
  4. ↑ Burton JP, Devillard E, Cadieux PA, Hammond JA, Reid G (Apr 21, 2004). "Detection of Atopobium vaginae in postmenopausal women by cultivation-independent methods warrants further investigation". J Clin Microbiol. 42 (16): 1829–1831. doi:10.1128/jcm.42.4.1829-1831.2004. PMC 387601. PMID 15071062.
  5. ↑ Burton JP, Chilcott CN, Al-Qumber M, Brooks HJ, Wilson D, Tagg JR, Devenish C (October 2005). "A preliminary survey of Atopobium vaginae in women attending the Dunedin gynaecology out-patients clinic: is the contribution of the hard-to-culturemicrobiota overlooked in gynaecological disorders?". The Australian and New Zealand Journal of Obstetrics and Gynaecology. 45 (5): 450–2. doi:10.1111/j.1479-828X.2005.00456.x. PMID 16171487. S2CID 44888920.
  6. ↑ Ahn, J.; Sinha, R.; Pei, Z.; Dominianni, C.; Wu, J.; Shi, J.; Goedert, J. J.; Hayes, R. B.; Yang, L. (18 December 2013). "Human Gut Microbiome and Risk for Colorectal Cancer". J Natl Cancer Inst. 105 (24): 1907–1911. doi:10.1093/jnci/djt300. PMC 3866154. PMID 24316595.
  7. ↑ Altonsy, M.O.; Andrews, S.C.; Tuohy, K.M. (28 February 2010). "Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enterophathogenic bacteria: mediation by the mitochondrial pathway". International Journal of Food Microbiology. 137 (2–3): 190–203. doi:10.1016/j.ijfoodmicro.2009.11.015. PMID 20036023.
  8. ↑ Euzéby JP, Parte AC. "Atopobium". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved June 23, 2021.
  9. ↑ Sayers; et al. "Atopobium". National Center for Biotechnology Information (NCBI) taxonomy database. Retrieved 2021-03-20.
  10. ↑ "The LTP". Retrieved 20 November 2023.
  11. ↑ "LTP_all tree in newick format". Retrieved 20 November 2023.
  12. ↑ "LTP_08_2023 Release Notes" (PDF). Retrieved 20 November 2023.
  13. ↑ "GTDB release 08-RS214". Genome Taxonomy Database. Retrieved 10 May 2023.
  14. ↑ "bac120_r214.sp_label". Genome Taxonomy Database. Retrieved 10 May 2023.
  15. ↑ "Taxon History". Genome Taxonomy Database. Retrieved 10 May 2023.
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