Amar J. S. Klar
Born
Amar Jit Singh Klar

(1947-04-01)April 1, 1947
Punjab, India
DiedMarch 5, 2017(2017-03-05) (aged 69)
Frederick, Maryland, United States
NationalityIndian
EducationPunjab Agricultural University
University of Wisconsin–Madison
Known forEpigenetics research
SpouseKuljit Klar
ChildrenNitasha and Amy
Scientific career
FieldsGenetics
InstitutionsCold Spring Harbor Laboratory
National Cancer Institute
ThesisEnzyme regulation during vegetative growth and aporulation in Saccharomyces cerevisiae: galactose catabolic enzymes and proteinases (1975)
Doctoral advisorHarlyn O. Halvorson

Amar Jit Singh Klar (April 1, 1947 – March 5, 2017) was an Indian-American yeast geneticist and epigenetics researcher.[1][2] He received media attention for his research on the genetics of human traits, including handedness and the direction of hair whorls.[3][4][5]

Early life and education

Klar was born on April 1, 1947, in Lyallpur, which was then part of Punjab, India, but is now part of Pakistan.[6]: 94  He earned his undergraduate degree in 1967 and his master's degree in 1969, both from Punjab Agricultural University. In 1975, he received his Ph.D. in bacteriology from the University of Wisconsin–Madison, where he studied under Harlyn O. Halvorson. He then completed a postdoc at the University of California, Berkeley.[2]

Career

In 1978, after getting a phone call from James Watson, Klar began doing yeast research at Cold Spring Harbor Laboratory (CSHL). He continued to work there until 1988, and served as director of their Delbrück Laboratory from 1985 until then.[2] In 1988, he left CSHL to join the National Cancer Institute (NCI) Gene Regulation and Chromosome Biology Laboratory, which was affiliated with the ABL Basic Research Program in Frederick, Maryland.[1][7] In 1999, he joined the National Institutes of Health's Center for Cancer Research located in Frederick[2] becoming a Principal Investigator. He studied genetics in yeast and applied his great skills and understanding of that complex system to the understanding of complex inheritance patterns of psychotic disease in individuals and families.

Scientific contributions

Amar Klar developed his career as yeast geneticist at Cold Spring Harbor Laboratoryin a group of other geneticists that included James Hicks and Jeffrey Strathern.

His prolific career produced numerous publications, many of which were published in premiere journals such as Nature and Science.

The novel "The Marriage Plot" written by Pulitzer prize winner Jeffrey Eugenides was loosely based on Klar's sentinel yeast genetics research while at Cold Spring Harbor Laboratory.

Personal life and death

Klar grew up in a small village in India, born before the India/Pakistan partition in what is now called Pakistan. He emigrated to the United States on scholarship initially joining Brandeis University. He was married to Kuljit Klar, with whom he had two daughters: Nitasha and Amy.[7] He died in Frederick, Maryland, on March 5, 2017, in a fall from a ladder at his home. His obituary in the Journal of Biosciences stated that he died from a " head injury".[1][8]

References

  1. 1 2 3 Singh, Jagmohan (September 2017). "Amar Klar: A giant among scientists (1947–2017)". Journal of Biosciences. 42 (3): 355–357. doi:10.1007/s12038-017-9704-7. ISSN 0250-5991. PMID 29358548. S2CID 3726152.
  2. 1 2 3 4 "Amar Klar - In Memory". Cold Spring Harbor Laboratory. Retrieved 2019-09-19.
  3. ↑ "In New Theory, Single Gene Makes a Left-Hander". The New York Times. Associated Press. 1997-07-30. ISSN 0362-4331. Retrieved 2019-09-19.
  4. ↑ Pearson, Helen (2003-09-04). "Handedness equals hairstyle". Nature. doi:10.1038/news030901-7. Retrieved 2019-09-19.
  5. ↑ Smith, Linell (1997-12-11). "A Show of Hands". The Baltimore Sun. Retrieved 2019-09-19.
  6. ↑ Klar, Amar (1975). Enzyme regulation during vegetative growth and aporulation in Saccharomyces cerevisiae: galactose catabolic enzymes and proteinases (Ph.D. thesis). University of Wisconsin–Madison.
  7. 1 2 "In Memoriam: Amar J.S. Klar, Ph.D." Center for Cancer Research. 2017-03-08. Retrieved 2019-09-19.
  8. ↑ Grant, Bob (2017-03-07). "Prominent Epigeneticist Dies". The Scientist. Retrieved 2019-09-19.
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