Alpha-1-microglobulin/bikunin precursor

AMBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BIK, 3QKG, 4ES7, 4U30
Identifiers
Aliases	AMBP, A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI, alpha-1-microglobulin/bikunin precursor
External IDs	OMIM: 176870 MGI: 88002 HomoloGene: 1234 GeneCards: AMBP
Gene location (Human)
Chr.	Chromosome 9 (human)
End	114,078,328 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	63,073,036 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gallbladder; ; body of pancreas; ; islet of Langerhans; ; oocyte; ; pancreatic epithelial cell; ; secondary oocyte; ; kidney; ; kidney tubule; ; body of stomach;
	Top expressed in
	left lobe of liver; ; gallbladder; ; yolk sac; ; abdominal wall; ; right lobe of liver; ; islet of Langerhans; ; sexually immature organism; ; liver parenchyma; ; pyloric antrum; ; vein;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; calcium channel inhibitor activity; protein homodimerization activity; calcium oxalate binding; protein binding; heme binding; serine-type endopeptidase inhibitor activity; small molecule binding; IgA binding;
Cellular component	blood microparticle; intracellular membrane-bounded organelle; plasma membrane; extracellular region; cell surface; extracellular exosome; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	negative regulation of peptidase activity; female pregnancy; receptor-mediated endocytosis; negative regulation of JNK cascade; heme catabolic process; negative regulation of immune response; cell adhesion; protein catabolic process; viral process; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	259
	11699
	ENSG00000106927
	ENSMUSG00000028356
	P02760
	Q07456
	NM_001633
	NM_007443
	NP_001624
	NP_031469
	Wikidata
View/Edit Human	View/Edit Mouse

Protein AMBP is a protein that in humans is encoded by the AMBP gene.^[5]^[6]^[7]

Interactions

Alpha-1-microglobulin/bikunin precursor has been shown to interact with CD79A.^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106927 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028356 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Vetr H, Gebhard W (1990). "Structure of the human alpha 1-microglobulin-bikunin gene". Biol. Chem. Hoppe-Seyler. 371 (12): 1185–96. doi:10.1515/bchm3.1990.371.2.1185. PMID 1708673.
↑ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
↑ "Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor".
↑ Grubb AO, López C, Tejler L, Mendez E (December 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem. 258 (23): 14698–707. doi:10.1016/S0021-9258(17)43919-6. PMID 6196366.
↑ Berggård T, Thelin N, Falkenberg C, Enghild JJ, Akerström B (May 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem. 245 (3): 676–83. doi:10.1111/j.1432-1033.1997.00676.x. PMID 9183005.

Akerström B, Lögdberg L, Berggård T, Osmark P, Lindqvist A (2000). "alpha(1)-Microglobulin: a yellow-brown lipocalin". Biochim. Biophys. Acta. 1482 (1–2): 172–84. doi:10.1016/S0167-4838(00)00157-6. PMID 11058759.
Kobayashi H, Suzuki M, Hirashima Y, Terao T (2003). "The protease inhibitor bikunin, a novel anti-metastatic agent". Biol. Chem. 384 (5): 749–54. doi:10.1515/BC.2003.083. PMID 12817471. S2CID 38608465.
Ekström B, Berggård I (1977). "Human alpha1-microglobulin. Purification procedure, chemical and physiochemical properties". J. Biol. Chem. 252 (22): 8048–57. doi:10.1016/S0021-9258(17)40934-3. PMID 72071.
Escribano J, Lopex-Otin C, Hjerpe A, Grubb A, Mendez E (1990). "Location and characterization of the three carbohydrate prosthetic groups of human protein HC". FEBS Lett. 266 (1–2): 167–70. doi:10.1016/0014-5793(90)81531-R. PMID 1694784. S2CID 36320110.
Diarra-Mehrpour M, Bourguignon J, Sesboüé R, Salier JP, Léveillard T, Martin JP (1990). "Structural analysis of the human inter-alpha-trypsin inhibitor light-chain gene". Eur. J. Biochem. 191 (1): 131–9. doi:10.1111/j.1432-1033.1990.tb19102.x. PMID 1696200.
Gebhard W, Schreitmüller T, Vetr H, Wachter E, Hochstrasser K (1990). "Complementary DNA and deduced amino acid sequences of procine alpha 1-microglobulin and bikunin". FEBS Lett. 269 (1): 32–6. doi:10.1016/0014-5793(90)81112-2. PMID 1696914. S2CID 84271910.
Falkenberg C, Grubb A, Akerström B (1990). "Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue". J. Biol. Chem. 265 (27): 16150–7. doi:10.1016/S0021-9258(17)46201-6. PMID 1697852.
Nazimova SV, Akulenko IV, Zaĭtseva IV, Zaraĭskiĭ EI, Posiseeva LV (1990). "[Immunoenzyme analysis of placenta-specific alpha(1)-microglobulin in the blood serum in normal and pathological pregnancy]". Akush Ginekol (Mosk) (7): 70–2. PMID 1700638.
Escribano J, Grubb A, Calero M, Méndez E (1991). "The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC". J. Biol. Chem. 266 (24): 15758–63. doi:10.1016/S0021-9258(18)98474-7. PMID 1714898.
Enghild JJ, Salvesen G, Hefta SA, Thøgersen IB, Rutherfurd S, Pizzo SV (1991). "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor". J. Biol. Chem. 266 (2): 747–51. doi:10.1016/S0021-9258(17)35235-3. PMID 1898736.
Reisinger P, Hochstrasser K, Albrecht GJ, Lempart K, Salier JP (1985). "Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinase". Biol. Chem. Hoppe-Seyler. 366 (5): 479–83. doi:10.1515/bchm3.1985.366.1.479. PMID 2408638.
Bourguignon J, Diarra-Mehrpour M, Sesboüé R, Frain M, Sala-Trepat JM, Martin JP, Salier JP (1985). "Human inter-alpha-trypsin-inhibitor: characterization and partial nucleotide sequencing of a light chain-encoding cDNA". Biochem. Biophys. Res. Commun. 131 (3): 1146–53. doi:10.1016/0006-291X(85)90210-4. PMID 2413856.
Méndez E, Fernández-Luna JL, Grubb A, Leyva-Cobián F (1986). "Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis". Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1472–5. Bibcode:1986PNAS...83.1472M. doi:10.1073/pnas.83.5.1472. PMC 323098. PMID 2419908.
Traboni C, Cortese R (1986). "Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin)". Nucleic Acids Res. 14 (15): 6340. doi:10.1093/nar/14.15.6340. PMC 311643. PMID 2428011.
Kaumeyer JF, Polazzi JO, Kotick MP (1986). "The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC)". Nucleic Acids Res. 14 (20): 7839–50. doi:10.1093/nar/14.20.7839. PMC 311818. PMID 2430261.
Zaraĭskiĭ EI, Nazimova SV, Olefirenko GA, Pchelkina ZM, Petrunin DD, Tatarinov IuS, Fuks BB (1990). "[Immunoenzyme analysis of placenta-specific alpha 1-microglobulin in the serum of blood donors]". Vopr. Med. Khim. 35 (5): 130–2. PMID 2482577.
Schreitmüller T, Hochstrasser K, Reisinger PW, Wachter E, Gebhard W (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler. 368 (8): 963–70. doi:10.1515/bchm3.1987.368.2.963. PMID 3663330.
Morii M, Travis J (1985). "The reactive site of human inter-alpha-trypsin inhibitor is in the amino-terminal half of the protein". Biol. Chem. Hoppe-Seyler. 366 (1): 19–21. doi:10.1515/bchm3.1985.366.1.19. PMID 3890890.

External links

The MEROPS online database for peptidases and their inhibitors: LI02-001

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106927 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028356 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1708673-5] Vetr H, Gebhard W (1990). "Structure of the human alpha 1-microglobulin-bikunin gene". Biol. Chem. Hoppe-Seyler. 371 (12): 1185–96. doi:10.1515/bchm3.1990.371.2.1185. PMID 1708673.

[pmid1385302-6] Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.

[entrez-7] "Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor".

[pmid6196366-8] Grubb AO, López C, Tejler L, Mendez E (December 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem. 258 (23): 14698–707. doi:10.1016/S0021-9258(17)43919-6. PMID 6196366.

[pmid9183005-9] Berggård T, Thelin N, Falkenberg C, Enghild JJ, Akerström B (May 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem. 245 (3): 676–83. doi:10.1111/j.1432-1033.1997.00676.x. PMID 9183005.

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[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

Interactions

See also

References

Further reading

External links