ARHGAP8
Identifiers
AliasesARHGAP8, BPGAP1, PP610, Rho GTPase activating protein 8
External IDsOMIM: 609405 MGI: 1920417 HomoloGene: 23645 GeneCards: ARHGAP8
Orthologs
SpeciesHumanMouse
Entrez

23779

73167

Ensembl

ENSG00000241484

ENSMUSG00000078954

UniProt

P85298

Q9CXP4

RefSeq (mRNA)

NM_181335
NM_001017526
NM_001198726

NM_001164627
NM_001164628
NM_001205334
NM_028455

RefSeq (protein)

NP_001017526
NP_001185655
NP_851852

NP_001158099
NP_001158100
NP_001192263
NP_082731

Location (UCSC)Chr 22: 44.75 – 44.86 MbChr 15: 84.6 – 84.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene.[5][6]

Function

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000241484 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078954 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  6. 1 2 "Entrez Gene: ARHGAP8 Rho GTPase activating protein 8".

Further reading


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