APPL2

APPL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H8S, 5C5B
Identifiers
Aliases	APPL2, DIP13B, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
External IDs	OMIM: 606231 MGI: 2384914 HomoloGene: 10046 GeneCards: APPL2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	105,236,203 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	83,484,602 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; rectum; ; Achilles tendon; ; stromal cell of endometrium; ; canal of the cervix; ; bronchial epithelial cell; ; ganglionic eminence; ; tibial nerve; ; right uterine tube; ; gallbladder;
	Top expressed in
	retinal pigment epithelium; ; ciliary body; ; iris; ; cerebellar cortex; ; parotid gland; ; cerebellar vermis; ; lacrimal gland; ; epithelium of stomach; ; submandibular gland; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphatidylserine binding; phosphatidylinositol binding; protein homodimerization activity; protein-containing complex binding;
Cellular component	cytoplasm; NuRD complex; endosome; early endosome membrane; endosome membrane; extracellular exosome; membrane; nucleus; ruffle; plasma membrane; cytoplasmic vesicle; vesicle; early phagosome; ruffle membrane; early phagosome membrane; macropinosome; phagocytic vesicle membrane; cell projection; phagocytic vesicle;
Biological process	cell cycle; cell population proliferation; signal transduction; diet induced thermogenesis; transforming growth factor beta receptor signaling pathway; cold acclimation; regulation of fibroblast migration; signaling; adiponectin-activated signaling pathway; regulation of toll-like receptor 4 signaling pathway; cellular response to hepatocyte growth factor stimulus; glucose homeostasis; regulation of innate immune response; negative regulation of fatty acid oxidation; negative regulation of glucose import; negative regulation of neurogenesis; protein homotetramerization; positive regulation of phagocytosis, engulfment; positive regulation of cold-induced thermogenesis; negative regulation of cytokine production involved in inflammatory response; negative regulation of cellular response to insulin stimulus; positive regulation of macropinocytosis; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of neural precursor cell proliferation; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	55198
	216190
	ENSG00000136044
	ENSMUSG00000020263
	Q8NEU8
	Q8K3G9
	NM_001251904; NM_001251905; NM_018171
	NM_145220
	NP_001238833; NP_001238834; NP_060641
	NP_660255
	Wikidata
View/Edit Human	View/Edit Mouse

DCC-interacting protein 13-beta is a protein that in humans is encoded by the APPL2 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136044 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020263 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bonaglia MC, Giorda R, Borgatti R, Felisari G, Gagliardi C, Selicorni A, Zuffardi O (Jul 2001). "Disruption of the ProSAP2 Gene in a t(12;22)(q24.1;q13.3) Is Associated with the 22q13.3 Deletion Syndrome". Am J Hum Genet. 69 (2): 261–8. doi:10.1086/321293. PMC 1235301. PMID 11431708.
↑ Nechamen CA, Thomas RM, Dias JA (Nov 2006). "APPL1, APPL2, Akt2 and FOXO1a Interact with FSHR in a Potential Signaling Complex". Mol Cell Endocrinol. 260–262: 93–9. doi:10.1016/j.mce.2006.08.014. PMC 1782224. PMID 17030088.
↑ "Entrez Gene: APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2".

External links

Human APPL2 genome location and APPL2 gene details page in the UCSC Genome Browser.

Mao X, Kikani CK, Riojas RA, et al. (2006). "APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function". Nat. Cell Biol. 8 (5): 516–23. doi:10.1038/ncb1404. PMID 16622416. S2CID 21273764.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Miaczynska M, Christoforidis S, Giner A, et al. (2004). "APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment". Cell. 116 (3): 445–56. doi:10.1016/S0092-8674(04)00117-5. PMID 15016378. S2CID 18281503.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136044 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020263 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11431708-5] Bonaglia MC, Giorda R, Borgatti R, Felisari G, Gagliardi C, Selicorni A, Zuffardi O (Jul 2001). "Disruption of the ProSAP2 Gene in a t(12;22)(q24.1;q13.3) Is Associated with the 22q13.3 Deletion Syndrome". Am J Hum Genet. 69 (2): 261–8. doi:10.1086/321293. PMC 1235301. PMID 11431708.

[pmid17030088-6] Nechamen CA, Thomas RM, Dias JA (Nov 2006). "APPL1, APPL2, Akt2 and FOXO1a Interact with FSHR in a Potential Signaling Complex". Mol Cell Endocrinol. 260–262: 93–9. doi:10.1016/j.mce.2006.08.014. PMC 1782224. PMID 17030088.

[entrez-7] "Entrez Gene: APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2".

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References

External links

Further reading