A20 cells, also called ATCC TIB-208, is a cell line originally derived from B-cell lymphoma in an old BALB/c mouse.[1] AT20 cells are BALB/c lymphoma cells derived from spontaneous reticulum cell neoplasm.[2] ATCC TIB-208 cells originated from B-cell lymphoma in the reticulum cell sarcoma of an elderly BALB/c mouse.[3] A20 cells are used in medical research such as drug screening or vaccine target selection.[4][5][6] A20 cells are also highly responsive to immunomodulatory antibodies, and are therefore used frequently in immunotherapy drug studies.[3]

References

  1. ↑ Kim, KJ; Kanellopoulos-Langevin, C; Merwin, RM; Sachs, DH; Asofsky, R (1979). "Establishment and characterization of BALB/c lymphoma lines with B cell properties". Journal of Immunology. 122 (2): 549–554. doi:10.4049/jimmunol.122.2.549. PMID 310843.
  2. ↑ Priem, Dario; van Loo, Geert; Bertrand, Mathieu J. M. (2020-05-01). "A20 and Cell Death-driven Inflammation". Trends in Immunology. 41 (5): 421–435. doi:10.1016/j.it.2020.03.001. ISSN 1471-4906. PMID 32241683. S2CID 214771288.
  3. 1 2 "A20: Modeling B cell lymphoma in mice". drugdevelopment.labcorp.com. Retrieved 2022-12-05.
  4. ↑ Meziane el, K; Bhattacharyya, T; Armstrong, AC; Qian, C; Hawkins, RE; Stern, PL; Dermime, S (2004-10-10). "Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma". International Journal of Cancer. 111 (6): 910–920. doi:10.1002/ijc.20332. PMID 15300803.
  5. ↑ Siegel, S; Wagner, A; Kabelitz, D; Marget, M; Coggin J, Jr; Barsoum, A; Rohrer, J; Schmitz, N; Zeis, M (2003-12-15). "Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies". Blood. 102 (13): 4416–23. doi:10.1182/blood-2003-01-0198. PMID 12869512. S2CID 9814435.
  6. ↑ Siegel, S; Wagner, A; Schmitz, N; Zeis, M (2003). "Induction of antitumour immunity using survivin peptide-pulsed dendritic cells in a murine lymphoma model". British Journal of Haematology. 122 (6): 911–4. doi:10.1046/j.1365-2141.2003.04535.x. PMID 12956760.
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