Δ4-3-Oxosteroid 5β-reductase
Identifiers
EC no.1.3.1.3
CAS no.2604034
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5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (EC 1.3.1.3, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase.[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction

(1) 5β-cholestan-3-one + NADP+ cholest-4-en-3-one + NADPH + H+
(2) 17,21-dihydroxy-5β-pregnane-3,11,20-trione + NADP+ cortisone + NADPH + H+

The human enzyme efficiently acts on progesterone, 17α-hydroxyprogesterone, androstenedione, and testosterone to 5β-reduced metabolites. It can also act on aldosterone, corticosterone and cortisol, to some extent.

See also

References

  1. ↑ Dorfman RI, Forchielli E (November 1956). "Separation of delta 4-5 alpha-hydrogenases from rat liver homogenates". The Journal of Biological Chemistry. 223 (1): 443–8. PMID 13376613.
  2. ↑ Brown-Grant K, Forchielli E, Dorfman RI (May 1960). "The delta4-hydrogenases of guinea pig adrenal gland". The Journal of Biological Chemistry. 235: 1317–20. PMID 13805063.
  3. ↑ Levy, H.R. & Talalay, P. (1957). "Enzymatic introduction of double bonds into steroid ring A". J. Am. Chem. Soc. 79 (10): 2658–2659. doi:10.1021/ja01567a089.
  4. ↑ Tomkins GM (March 1957). "The enzymatic reduction of delta 4-3-ketosteroids". The Journal of Biological Chemistry. 225 (1): 13–24. PMID 13416214.
  5. ↑ Sugimoto Y, Yoshida M, Tamaoki B (December 1990). "Purification of 5 beta-reductase from hepatic cytosol fraction of chicken". The Journal of Steroid Biochemistry and Molecular Biology. 37 (5): 717–24. doi:10.1016/0960-0760(90)90356-p. PMID 2278855. S2CID 54431282.
  6. ↑ Furuebisu M, Deguchi S, Okuda K (March 1987). "Identification of cortisone 5 beta-reductase as delta 4-3-ketosteroid 5 beta-reductase". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 912 (1): 110–4. doi:10.1016/0167-4838(87)90253-6. PMID 3828348.
  7. ↑ Okuda A, Okuda K (June 1984). "Purification and characterization of delta 4-3-ketosteroid 5 beta-reductase". The Journal of Biological Chemistry. 259 (12): 7519–24. PMID 6736016.
  8. ↑ Charbonneau A, The VL (January 2001). "Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1517 (2): 228–35. doi:10.1016/s0167-4781(00)00278-5. PMID 11342103.
  9. ↑ Kondo KH, Kai MH, Setoguchi Y, Eggertsen G, Sjöblom P, Setoguchi T, Okuda KI, Björkhem I (January 1994). "Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme". European Journal of Biochemistry. 219 (1–2): 357–63. doi:10.1111/j.1432-1033.1994.tb19947.x. PMID 7508385.
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