Game 1

After game 1, Fans rush the field and police protect Nick Altrock

White Sox starter Nick Altrock faced Cub starter Mordecai "Three-Fingered" Brown in game 1. Both were perfect through three innings. The Cubs put a runner on second in the bottom of the fourth inning, but couldn't score. In the top of the fifth, George Rohe tripled to lead off, then scored on an error at home when Patsy Dougherty reached on a fielder's choice. The Sox scored a second run in the top of the sixth. Altrock walked, and was sacrificed to second base by Ed Hahn. Fielder Jones then singled to center but Altrock was thrown out at the plate, Jones taking second on the throw home. He took third on Cub catcher Johnny Kling's passed ball, and Frank Isbell drove him home with a single. The Cubs struck back in their half of the sixth. Kling walked and Brown singled with nobody out. After Solly Hofman sacrificed the runners to second and third, Altrock's wild pitch scored Kling and sent Brown to third, giving him little margin for error with only one out, but he got Jimmy Sheckard to pop out and Frank Schulte to ground out to end the threat. He pitched beautifully for the rest of the game, allowing only one more Cub to reach second, retaining the 2–1 lead for a Game 1 Sox win.

Game 2

Ed Reulbach, winning pitcher of Game 2

Ed Reulbach was called on for the Cubs to face White Sox hurler Doc White. After matching 1–2–3 first innings, things started to fall apart for White. After cleanup-hitting first baseman Frank Chance led off the top of the second with a strikeout, third baseman Harry Steinfeldt singled to left field and shortstop Joe Tinker beat out a bunt. Cubs second baseman Johnny Evers then reached on a two-base error by White Sox second baseman Frank Isbell, scoring Steinfeldt for an unearned run and moving Tinker and Evers to second and third. Catcher Johnny Kling was then intentionally walked to load the bases and bring up the pitcher, still with only one out. Reulbach squeeze-bunted Tinker home for a second unearned run, moving Evers to third and Kling to second with two out. Solly Hofman followed with an infield single to shortstop Lee Tannehill, scoring Evers for a third unearned run, but when Kling tried to score from second, he was thrown out at home plate, ending the rally. The Cubs added a fourth unearned run in the third, ending Doc White's day on the mound. The Sox scored in the bottom of the fifth inning with an unearned run, thanks to a wild pitch and an error. The Cubs scored three more runs, all earned, in the sixth and eighth to win Game 2 7–1 and tie the Series at one game apiece. Reulbach pitched the first one-hitter in World Series history.

Game 3

Jack Pfiester pitching in Game 3

After allowing two first-inning hits, Sox starter "Big Ed" Walsh didn't give up another and struck out 12, giving the Sox a 2–1 edge in the series. After Fred Schulte's first inning two-out double, Walsh retired the next 25 of 27 Cub batters to face him. Third baseman George Rohe cracked a two-out, bases-loaded triple to left in the top of the sixth off Jack Pfiester for the only runs of the game.

Game 4

Game 4 winning pitcher Mordecai Brown

Looking to even the Series, the Cubs started Mordecai Brown on one day's rest who pitched 5+2⁄3 innings of no-hit ball for the Cubs before settling for a two-hitter. Nick Altrock, who faced and defeated Brown in game 1, was the hard-luck loser, with the only run of the game coming on Johnny Evers' two-out single in the top of the seventh scoring Frank Chance. The Sox put the tying run on second base in the top of the ninth thanks to a two-out walk and a passed ball, but Frank Isbell grounded out to end the threat. The game took just 96 minutes and evened the Series at two games apiece.

Game 5

Game 5 at West Side Grounds

Game 5 was a wild affair with a total of 18 hits, ten walks, six errors, two hit batsmen, three wild pitches and a steal of home. The Cubs allowed a first inning run to the Sox, then scored three unearned runs on two Sox errors to take an early lead. The Sox tied the game in the third on George Davis' theft of home on the front end of a double steal and then took the lead for good with a four-run rally in the fourth and held on for the victory to take a 3–2 lead in the series. A 12-hit attack led by Frank Isbell's four doubles were enough to overcome seven unearned runs by the Cubs caused by six errors committed by the normally solid Sox defense. "Big" Ed Walsh earned his second win of the series, although he needed three innings of relief help from Doc White.

Game 6

South Side Park during Game 6

Mordecai Brown, again pitching on only one day of rest, didn't make it out of the second inning as the Hitless Wonders White Sox stunned the 116–36 Cubs in the Series finale. The Sox battered Brown for seven runs on eight hits while getting a solid pitching performance from Doc White. Although the Cubs scored a run and loaded the bases in the ninth, White got Frank Schulte to ground out for the final out of the series and the White Sox won the World Series.

The powerful Cubs went on to win the next two World Series from the Detroit Tigers, despite falling far short of 116 wins in either season, for the last Cubs win in a World Series for over a hundred years.

This game remains the only time the Chicago White Sox have clinched a postseason series in their home ballpark. It was the only time a Chicago-based team had ever clinched a series at home until the Cubs won the 2015 National League Division Series on their home field.