nociplastic pain

nociplastic pain (uncountable)

1. (medicine) Heightened responsiveness to sensory input, thought to result from dysfunction in the processing of pain signals by the central nervous system.

   Synonym: central sensitisation

   • 2019, Mark A. Jones, Darren A. Rivett, Clinical Reasoning in Musculoskeletal Practice, Elsevier, 2nd Edition, E-book Edition, page 40,

     Nociplastic pain is clearly dysfunctional as it serves no protective benefit to the people experiencing it.

     Nociplastic pain is significantly disproportionate to any plausible tissue contributions, persists beyond expected tissue healing times and may be recurrent in nature.

   • 2022, Deeba Minhas, Daniel J. Clauw, 88: Fibromyalgia and related syndromes, Marc C. Hochberg, Josef S. Smolen, Michael E. Weinblatt, Michael H. Weisman, Ellen M Gravallese, Desiree van der Heijde (editors), Rheumatology, Elsevier, 8th Edition, page 740,

     Fibromyalgia (FM) is the prototypical nociplastic pain syndrome.

   • 2022, Betsy Myers, June Hanks, Management of Common Orthopaedic Disorders, Wolters Kluwer, unnumbered page:

     Thus, nociplastic pain is linked with, but not synonymous with, central sensitization. Nociplastic pain is a maladaptive nervous system dysfunction associated with altered nociceptive processing and increased responsiveness to subthreshold afferent input^19,21,26 and is chronic by definition.