Étienne-Émile Baulieu

Etienne-Emile Baulieu (ur. 12 grudnia 1926 w Strasburgu) – francuski lekarz żydowskiego pochodzenia, biochemik i endokrynolog. Emerytowany profesor nauk medycznych.

Życiorys

Był dyrektorem Research Unit w INSERM, oraz profesorem biochemii na Wydziale Medycyny Bicêtro Uniwersytetu Paryskiego. W latach 2003 i 2004 sprawował funkcję prezydenta we Francuskiej Akademii Nauk. Zajmuje się badaniami nad hormonami steroidowymi i ich funkcją w procesie starzenia się organizmu, rozrodczości i procesach nowotworowych. Odkrywca produkowanego przez nadnercza hormonu DHEA i jego roli w procesie starzenia się mózgu. Wynalazł wczesnoporonną pigułkę RU-486. Laureat wielu międzynarodowych nagród i wyróżnień, m.in.:

doctor honoris causa Tufts University w Bostonie;
doctor honoris causa University of Gandawa;
doctor honoris causa Karolinska Institutet w Sztokholmie.

Kawaler Legii Honorowej.

Najważniejsze publikacje naukowe

E.E.E.E. Baulieu E.E.E.E., I.I. Lasnizki I.I., P.P. Robel P.P., Metabolism of testosterone and action of metabolites on prostate glands grown in organ culture, „Nature”, 219 (5159), 1968, s. 1155–1156, DOI: 10.1038/2191155a0, PMID: 5675630 .
E.E.E.E. Baulieu E.E.E.E., Etudes Sur Le Mode D'action Des Hormones Steroides Sexuelles : Metabolisme Au Niveau Des Organes Cibles Et Liaison a Des Proteines Specifiques, Paris, New York: Gordon & Breach, 1974, ISBN 978-0-677-50650-0 .
E.E.E.E. Baulieu E.E.E.E. i inni, Steroid-induced meiotic division in Xenopus laevis oocytes: surface and calcium, „Nature”, 275 (5681), 1978, s. 593–598, DOI: 10.1038/275593a0, PMID: 30046 .

J.J. Finidori-Lepicard J.J. i inni, Progesterone inhibits membrane-bound adenylate cyclase in Xenopus laevis oocytes, „Nature”, 292 (5820), 1981, s. 255–257, DOI: 10.1038/292255a0, PMID: 7195984 .

C.C. Corpéchot C.C. i inni, Characterization and measurement of dehydroepiandrosterone sulfate in rat brain, „Proceedings of the National Academy of Sciences of the United States of America”, 78 (8), 1981, s. 4704–4707, DOI: 10.1073/pnas.78.8.4704, PMID: 6458035, PMCID: PMC320231 .

I.I. Joab I.I. i inni, Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones, „Nature”, 308 (5962), 1984, s. 850–853, DOI: 10.1038/308850a0, PMID: 6201744 .

Jacques-LouisJ.L. Binet Jacques-LouisJ.L., Étienne-ÉmileÉ.É. Baulieu Étienne-ÉmileÉ.É., La Création vagabonde, Paris: Hermann, 1986, ISBN 2-7056-6051-8, OCLC 300913121 .

E.E.E.E. Baulieu E.E.E.E., Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor, „Science”, 245 (4924), 1989, s. 1351–1357, DOI: 10.1126/science.2781282, PMID: 2781282 .

Étienne-EmileÉ.E. Baulieu Étienne-EmileÉ.E., Génération pilule, Paris: Odile Jacob, 1990, ISBN 2-7381-0071-6, OCLC 417597744 .

Etienne-EmileE.E. Baulieu Etienne-EmileE.E., Paul A.P.A. Kelly Paul A.P.A., Hormones. From Molecules to Disease, Paris: Hermann, 1990, ISBN 2-7056-6030-5, OCLC 21035089 .

Etienne-EmileE.E. Baulieu Etienne-EmileE.E., MortM. Rosenblum MortM., The "abortion pill". RU-486, a woman's choice, New York: Simon & Schuster, 1991, ISBN 0-671-73816-X, OCLC 24288599 .

ClaudeC. Debru ClaudeC., Etienne-EmileE.E. Baulieu Etienne-EmileE.E., Bio-éthique et cultures, Paris: Librairie philosophique J. Vrin, 1991, ISBN 2-7116-9725-8, OCLC 406701902 .

M.C.M.C. Lebeau M.C.M.C. i inni, P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody, „Journal of Biological Chemistry”, 267 (7), 1992, s. 4281–4284, PMID: 1537818 .

R.R. Peyron R.R. i inni, Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol, „The New England Journal of Medicine”, 328 (21), 1993, s. 1509–1513, DOI: 10.1056/NEJM199305273282101, PMID: 8479487 .

C.C. Radanyi C.C., B.B. Chambraud B.B., E.E.E.E. Baulieu E.E.E.E., The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain, „Proceedings of the National Academy of Sciences of the United States of America”, 91 (23), 1994, s. 11197–11201, DOI: 10.1073/pnas.91.23.11197, PMID: 7526392, PMCID: PMC45194 .

H.L.H.L. Koenig H.L.H.L. i inni, Progesterone synthesis and myelin formation by Schwann cells, „Science”, 268 (5216), 1995, s. 1500–1503, DOI: 10.1126/science.7770777, PMID: 7770777 .

C.C. Berr C.C. i inni, Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study, „Proceedings of the National Academy of Sciences of the United States of America”, 93 (23), 1996, s. 13410–13415, DOI: 10.1073/pnas.93.23.13410, PMID: 8917605, PMCID: PMC24107 .

Étienne-EmileÉ.E. Baulieu Étienne-EmileÉ.E., FrançoiseF. Héritier FrançoiseF., HenriH. Leridon HenriH., Contraception. Contrainte ou liberté?, Paris: Odile Jacob, 1999, ISBN 2-7381-0722-2, OCLC 406793786 .

B.B. Chambraud B.B. i inni, Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein, „Proceedings of the National Academy of Sciences of the United States of America”, 96 (5), 1999, s. 2104–2109, DOI: 10.1073/pnas.96.5.2104, PMID: 10051602, PMCID: PMC26744 .

M.M. Schumacher M.M. i inni, Steroid synthesis and metabolism in the nervous system: trophic and protective effects, „Journal of Neurocytology”, 29 (5-6), 2000, s. 307–326, DOI: 10.1023/A:1007152904926, PMID: 11424948 .

Y.Y. Akwa Y.Y. i inni, The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms?, „Proceedings of the National Academy of Sciences of the United States of America”, 98 (24), 2001, s. 14033–14037, DOI: 10.1073/pnas.241503698, PMID: 11717462, PMCID: PMC61162 .

LiseL. Mazat LiseL. i inni, Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality, „Proceedings of the National Academy of Sciences of the United States of America”, 98 (14), 2001, s. 8145–8150, DOI: 10.1073/pnas.121177998, PMID: 11427700, PMCID: PMC35482 .

FlorenceF. Broué FlorenceF. i inni, A steroid hormone that extends the lifespan of Caenorhabditis elegans, „Aging Cell”, 6 (1), 2007, s. 87–94, DOI: 10.1111/j.1474-9726.2006.00268.x, PMID: 17266678 .

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