Zinc finger homeobox 2

ZFHX2
Identifiers
Aliases	ZFHX2, ZFH-5, ZNF409, ZFH5, MARSIS, zinc finger homeobox 2
External IDs	OMIM: 617828 MGI: 2686934 HomoloGene: 52657 GeneCards: ZFHX2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,556,192 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,329,781 bp
RNA expression pattern
	Top expressed in
	sperm; ; sural nerve; ; right uterine tube; ; ganglionic eminence; ; anterior pituitary; ; Brodmann area 9; ; prefrontal cortex; ; Brodmann area 23; ; hippocampus proper; ; hypothalamus;
	Top expressed in
	superior frontal gyrus; ; urethra; ; cerebellar cortex; ; male urethra; ; neural tube; ; superior cervical ganglion; ; ganglionic eminence; ; enteric nervous system; ; trigeminal ganglion; ; mesencephalon;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; zinc ion binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	adult behavior; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of sensory perception of pain;
	Sources:Amigo / QuickGO
Orthologs
	85446
	239102
	ENSG00000136367
	ENSMUSG00000040721
	Q9C0A1
	Q2MHN3
	NM_033400
	NM_001039198
	NP_207646
	NP_001034287
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger homeobox 2 is a protein that in humans is encoded by the ZFHX2 gene.^[5] It has been implicated in pain insensitivity.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136367 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040721 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Zinc finger homeobox 2".
↑ Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, et al. (December 2017). "A novel human pain insensitivity disorder caused by a point mutation in ZFHX2" (PDF). Brain. 141 (2): 365–376. doi:10.1093/brain/awx326. PMC 5837393. PMID 29253101.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136367 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040721 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger homeobox 2".

[HabibMatsuyama2017-6] Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, et al. (December 2017). "A novel human pain insensitivity disorder caused by a point mutation in ZFHX2" (PDF). Brain. 141 (2): 365–376. doi:10.1093/brain/awx326. PMC 5837393. PMID 29253101.

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