Chi-Huey Wong
翁啟惠
President of the Academia Sinica
In office
19 October 2006 – 10 May 2016
DeputyChen Chien-jen, Wang Fan-sen, etc.
Preceded byYuan T. Lee
Succeeded byWang Fan-sen (acting)
Personal details
Born (1948-08-03) August 3, 1948
Yizhu, Tainan County, Taiwan (now Chiayi County)
NationalityTaiwanese
American
Alma materNational Taiwan University
Massachusetts Institute of Technology
AwardsF. A. Cotton Medal (2008)
Arthur C. Cope Award (2012)
Wolf Prize in Chemistry (2014)
Robert Robinson Award (2015)
Welch Award in Chemistry (2021)
Scientific career
FieldsBiochemistry
Chemical biology
Institutions
Doctoral studentsCarlos F. Barbas III
Political partyIndependent

Chi-Huey Wong (Chinese: 翁啟惠; born 3 August 1948) is a Taiwanese-American biochemist. He is currently the Scripps Family Chair Professor at the Scripps Research Institute,[1] California in the department of chemistry. He is a member of the United States National Academy of Sciences, as awarded the 2014 Wolf Prize in Chemistry and 2015 RSC Robert Robinson Award.[2] Wong is also the holder of more than 100 patents and publisher of more 700 scholarly academic research papers under his name.[3]

Education

Wong  received his BS and MS in Biochemical Sciences from National Taiwan University in Taipei, followed by his PhD in chemistry in 1982 at the Massachusetts Institute of Technology under the direction of Professor George M. Whitesides to study the use of enzymes as catalysts in organic synthesis.[4]

Research and career

Wong continued his postdoctoral research work with George M. Whitesides at Harvard University from 1982 to 1983, then began his independent career at Texas A&M University in the chemistry department. During his tenure at Texas A&M University, he went through the ranks including assistant professor, associate professor, and professor of chemistry.

Wong was appointed as the Ernest W. Hahn Chair and professor of chemistry at the Scripps Research Institute and while he was a faculty member at Scripps, he also served as head of the Frontier Research Program on Glycotechnology at Riken in Japan[5] and director of the Genomics Research Center at Academia Sinica,[6] and was later appointed by the President of the Republic of China (Taiwan) as the President of Academia Sinica. Now, he is  serving at the Scripps Research Institute as Scripps Family Chair Professor of Chemistry.[7]

Wong is best known for his original contributions to glycoscience, especially his development of chemo-enzymatic methods for the practical synthesis of oligosaccharides[8][9][10][11][12] and glycoproteins[13][14][15][16][17] and the hierarchical and programmable one-pot synthesis method for the rapid preparation of a large number of oligosaccharides.[18] The original synthetic methods developed by Wong along with his work on the development of glycan microarrays[19][20][21][22][23][24][25] for the high-throughput analysis of protein-carbohydrate interaction and the design of glycosylation probes[26][27][28] have enabled not only the fundamental study of glycosylation in biology[29][30][31][32][33] but also the clinical development of carbohydrate-based medicines, including vaccines and homogeneous antibodies for the treatment of cancers and infectious diseases.[34][35][36][37][38]

In 2016, there was a media report, speculating that he was possibly involved in an insider trading scandal related to a biotech company OBI Pharma, Inc. headquartered in Taiwan, because his adult daughter had held shares in OBI Pharma.[39] When the allegations surfaced in March 2016, Wong was in the United States. He was quite disappointed by the false report and attempted to resign his position as president of the Academia Sinica twice. Both requests were rejected by the president of Taiwan, Ma Ying-jeou. After further consideration, Ma chose to approve Wong's resignation on 10 May.[40] In February 2018, the Shilin District Prosecutors Office announced that charges of insider trading against Wong had been dropped, though an investigation into a possible failure in disclosing his assets during tech transfer of his invention had not yet concluded by the Control Yuan.[41] In April 2022, the Control Yuan publicly announced that Wong did not violate any rule.[42]

Awards and honors

Memberships

Wong was elected as a member of the Academia Sinica in 1994, the American Academy of Arts and Science in 1996, the United States National Academy of Sciences in 2002, the World Academy of Sciences in 2007, the United States National Academy of Inventors in 2014, and also an Associate Member of the European Molecular Biology Organization in 2010.[49]

Bibliography

  • Enzymes in Synthetic Organic Chemistry. Pergamon Press. 1994. ISBN 978-0-08-050582-4
  • Carbohydrate Based Drug Discovery. Wiley Online Library. 2003. ISBN 978-3-527-60243-8
  • Current Status and New Challenges in Glycoscience. Springer. ISBN 978-4-431-54841-6

Patents

Wong obtained many patents for his inventions. His representative patents include Globo-H and related anti-cancer vaccines with novel glycolipid adjuvants (US9,603,913B2), Glycan arrays on PTFE-like aluminum coated glass slides and related methods (US8,680,020), Methods and compositions for immunization against virus (US8.741,311), Large scale enzymatic synthesis of oligosaccharides (US9,340,812), Methods for modifying human antibodies by glycan engineering (US10, 087,236), Compositions and methods relating to universal glycoforms for enhanced antibody efficacy (US10,023892), Crystal structure of bifunctional transglycosylase PBP1b from E. Coli and inhibitors thereof (US9890111B2),[50] Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants (US-8906832-B2),[51] Antibiotic compositions and related screening methods (US8916540B2),[52] Hirsutella Sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses (US8486914B2),[53] and Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins (US7943330B2).[54]

References

  1. ↑ "Chi-Huey Wong | Scripps Research". www.scripps.edu. Retrieved 2019-10-14.
  2. ↑ "RSC Robert Robinson Award 2015 Winner". www.rsc.org. Retrieved 2019-10-14.
  3. ↑ "Chi-Huey Wong – Google Scholar Citations". scholar.google.com.tw. Retrieved 2019-10-14.
  4. ↑ "Dr. Chi-Huey Wong's Personal Webpage". www.genomics.sinica.edu.tw. Archived from the original on 2016-04-04. Retrieved 2019-10-14.
  5. ↑ "Third RIKEN-Academia Sinica Joint Conference | RIKEN". www.riken.jp. Retrieved 2019-10-23.
  6. ↑ "Dr. Chi-Huey Wong's Personal Webpage". www.genomics.sinica.edu.tw. Archived from the original on 2016-04-04. Retrieved 2019-10-23.
  7. ↑ "70th Birthday: Chi-Huey Wong :: ChemViews Magazine :: ChemistryViews". www.chemistryviews.org. 3 August 2018. Retrieved 2019-10-23.
  8. ↑ Wong, C. (1989-06-09). "Enzymatic catalysts in organic synthesis". Science. 244 (4909): 1145–1152. Bibcode:1989Sci...244.1145W. doi:10.1126/science.2658059. ISSN 0036-8075. PMID 2658059.
  9. ↑ Koeller, Kathryn M.; Wong, Chi-Huey (2001). "Enzymes for chemical synthesis". Nature. 409 (6817): 232–240. Bibcode:2001Natur.409..232K. doi:10.1038/35051706. ISSN 0028-0836. PMID 11196651. S2CID 4339585.
  10. ↑ Sears, P. (2001-03-23). "Toward Automated Synthesis of Oligosaccharides and Glycoproteins". Science. 291 (5512): 2344–2350. Bibcode:2001Sci...291.2344S. doi:10.1126/science.1058899. PMID 11269314. S2CID 25853502.
  11. ↑ Machajewski, Timothy D.; Wong, Chi-Huey (2000). "The Catalytic Asymmetric Aldol Reaction". Angewandte Chemie International Edition. 39 (8): 1352–1375. doi:10.1002/(sici)1521-3773(20000417)39:8<1352::aid-anie1352>3.0.co;2-j. ISSN 1521-3773. PMID 10777624.
  12. ↑ Ichikawa, Yoshitaka; Lin, Ying Chih; Dumas, David P.; Shen, Gwo Jenn; Garcia-Junceda, Eduardo; Williams, Mark A.; Bayer, Robert; Ketcham, Catherine; Walker, Leslie E. (1992-11-01). "Chemical-enzymic synthesis and conformational analysis of sialyl Lewis X and derivatives". Journal of the American Chemical Society. 114 (24): 9283–9298. doi:10.1021/ja00050a007. ISSN 0002-7863.
  13. ↑ Koeller, Kathryn M.; Wong, Chi-Huey (2001). "Enzymes for chemical synthesis". Nature. 409 (6817): 232–240. Bibcode:2001Natur.409..232K. doi:10.1038/35051706. ISSN 0028-0836. PMID 11196651. S2CID 4339585.
  14. ↑ Sears, P.; Wong, Chi-Huey (2001-03-23). "Toward Automated Synthesis of Oligosaccharides and Glycoproteins". Science. 291 (5512): 2344–2350. Bibcode:2001Sci...291.2344S. doi:10.1126/science.1058899. PMID 11269314. S2CID 25853502.
  15. ↑ Witte, Krista; Sears, Pamela; Martin, Richard; Wong, Chi-Huey (1997-03-01). "Enzymatic Glycoprotein Synthesis: Preparation of Ribonuclease Glycoforms via Enzymatic Glycopeptide Condensation and Glycosylation". Journal of the American Chemical Society. 119 (9): 2114–2118. doi:10.1021/ja961846z. ISSN 0002-7863.
  16. ↑ Brik, Ashraf; Ficht, Simon; Yang, Yu-Ying; Wong, Chi-Huey (2006-11-01). "Sugar-Assisted Ligation of N-Linked Glycopeptides with Broad Sequence Tolerance at the Ligation Junction" (PDF). Journal of the American Chemical Society. 128 (46): 15026–15033. doi:10.1021/ja065601q. ISSN 0002-7863. PMID 17105315.
  17. ↑ Payne, Richard J.; Wong, Chi-Huey (2010-01-07). "Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins". Chemical Communications. 46 (1): 21–43. doi:10.1039/B913845E. ISSN 1364-548X. PMID 20024291.
  18. ↑ Galan, M. Carmen; Benito-Alifonso, David; Watt, Gregory M. (2011-05-21). "Carbohydrate chemistry in drug discovery". Organic & Biomolecular Chemistry. 9 (10): 3598–3610. doi:10.1039/C0OB01017K. ISSN 1477-0539. PMID 21409288.
  19. ↑ Fazio, Fabio; Bryan, Marian C.; Blixt, Ola; Paulson, James C.; Wong, Chi-Huey (2002-12-01). "Synthesis of Sugar Arrays in Microtiter Plate". Journal of the American Chemical Society. 124 (48): 14397–14402. doi:10.1021/ja020887u. ISSN 0002-7863. PMID 12452714.
  20. ↑ Blixt, Ola; Head, Steve; Mondala, Tony; Scanlan, Christopher; Huflejt, Margaret E.; Alvarez, Richard; Bryan, Marian C.; Fazio, Fabio; Calarese, Daniel; Stevens, James; Razi, Nahid (2004-12-07). "Printed covalent glycan array for ligand profiling of diverse glycan binding proteins". Proceedings of the National Academy of Sciences. 101 (49): 17033–17038. Bibcode:2004PNAS..10117033B. doi:10.1073/pnas.0407902101. ISSN 0027-8424. PMC 534418. PMID 15563589.
  21. ↑ Walker, Laura M.; Huber, Michael; Doores, Katie J.; Falkowska, Emilia; Pejchal, Robert; Julien, Jean-Philippe; Wang, Sheng-Kai; Ramos, Alejandra; Chan-Hui, Po-Ying; Moyle, Matthew; Mitcham, Jennifer L. (2011). "Broad neutralization coverage of HIV by multiple highly potent antibodies". Nature. 477 (7365): 466–470. Bibcode:2011Natur.477..466W. doi:10.1038/nature10373. ISSN 1476-4687. PMC 3393110. PMID 21849977.
  22. ↑ Pejchal, R.; Doores, K. J.; Walker, L. M.; Khayat, R.; Huang, P.-S.; Wang, S.-K.; Stanfield, R. L.; Julien, J.-P.; Ramos, A.; Crispin, M.; Depetris, R. (2011-11-25). "A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield". Science. 334 (6059): 1097–1103. Bibcode:2011Sci...334.1097P. doi:10.1126/science.1213256. ISSN 0036-8075. PMC 3280215. PMID 21998254.
  23. ↑ Shivatare, Sachin S.; Chang, Shih-Huang; Tsai, Tsung-I.; Tseng, Susan Yu; Shivatare, Vidya S.; Lin, Yih-Shyan; Cheng, Yang-Yu; Ren, Chien-Tai; Lee, Chang-Chun David; Pawar, Sujeet; Tsai, Charng-Sheng (2016). "Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies". Nature Chemistry. 8 (4): 338–346. Bibcode:2016NatCh...8..338S. doi:10.1038/nchem.2463. ISSN 1755-4330. PMC 4806563. PMID 27001729.
  24. ↑ Stewart-Jones, Guillaume B.E.; Soto, Cinque; Lemmin, Thomas; Chuang, Gwo-Yu; Druz, Aliaksandr; Kong, Rui; Thomas, Paul V.; Wagh, Kshitij; Zhou, Tongqing; Behrens, Anna-Janina; Bylund, Tatsiana (2016). "Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G". Cell. 165 (4): 813–826. doi:10.1016/j.cell.2016.04.010. PMC 5543418. PMID 27114034.
  25. ↑ Shivatare, Vidya S.; Shivatare, Sachin S.; Lee, Chang-Chun David; Liang, Chi-Hui; Liao, Kuo-Shiang; Cheng, Yang-Yu; Saidachary, Gannerla; Wu, Chung-Yi; Lin, Nan-Horng; Kwong, Peter D.; Burton, Dennis R. (2018-04-18). "Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies". Journal of the American Chemical Society. 140 (15): 5202–5210. doi:10.1021/jacs.8b00896. ISSN 0002-7863. PMID 29578688.
  26. ↑ Sawa, M.; Hsu, T.-L.; Itoh, T.; Sugiyama, M.; Hanson, S. R.; Vogt, P. K.; Wong, C.-H. (2006-08-15). "Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo". Proceedings of the National Academy of Sciences. 103 (33): 12371–12376. Bibcode:2006PNAS..10312371S. doi:10.1073/pnas.0605418103. ISSN 0027-8424. PMC 1567886. PMID 16895981.
  27. ↑ Hsu, Tsui-Ling; Hanson, Sarah R.; Kishikawa, Kuniyuki; Wang, Sheng-Kai; Sawa, Masaaki; Wong, Chi-Huey (2007-02-20). "Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells". Proceedings of the National Academy of Sciences. 104 (8): 2614–2619. Bibcode:2007PNAS..104.2614H. doi:10.1073/pnas.0611307104. ISSN 0027-8424. PMC 1815231. PMID 17296930.
  28. ↑ Shie, Jiun-Jie; Liu, Ying-Chih; Lee, Yu-Ming; Lim, Carmay; Fang, Jim-Min; Wong, Chi-Huey (2014-07-16). "An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence upon Triazole Formation". Journal of the American Chemical Society. 136 (28): 9953–9961. doi:10.1021/ja5010174. ISSN 0002-7863. PMID 24955871.
  29. ↑ Hanson, S. R.; Culyba, E. K.; Hsu, T.-L.; Wong, C.-H.; Kelly, J. W.; Powers, E. T. (2009-03-03). "The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability". Proceedings of the National Academy of Sciences. 106 (9): 3131–3136. Bibcode:2009PNAS..106.3131H. doi:10.1073/pnas.0810318105. ISSN 0027-8424. PMC 2651298. PMID 19204290.
  30. ↑ Huang, Yen-Wen; Yang, Hwai-I; Wu, Ying-Ta; Hsu, Tsui-Ling; Lin, Tzu-Wen; Kelly, Jeffery W.; Wong, Chi-Huey (2017-09-20). "Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency". Journal of the American Chemical Society. 139 (37): 12947–12955. doi:10.1021/jacs.7b03868. ISSN 0002-7863. PMID 28820257.
  31. ↑ Krasnova, Larissa; Wong, Chi-Huey (2016-06-02). "Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis". Annual Review of Biochemistry. 85 (1): 599–630. doi:10.1146/annurev-biochem-060614-034420. ISSN 0066-4154. PMID 27145845.
  32. ↑ Krasnova, Larissa; Wong, Chi-Huey (2019-03-06). "Oligosaccharide Synthesis and Translational Innovation". Journal of the American Chemical Society. 141 (9): 3735–3754. doi:10.1021/jacs.8b11005. ISSN 0002-7863. PMC 6538563. PMID 30716271.
  33. ↑ Chuang, Po-Kai; Hsiao, Michael; Hsu, Tsui-Ling; Chang, Chuan-Fa; Wu, Chung-Yi; Chen, Bo-Rui; Huang, Han-Wen; Liao, Kuo-Shiang; Chen, Chen-Chun; Chen, Chi-Long; Yang, Shun-Min (2019-02-26). "Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer". Proceedings of the National Academy of Sciences. 116 (9): 3518–3523. Bibcode:2019PNAS..116.3518C. doi:10.1073/pnas.1816946116. ISSN 0027-8424. PMC 6397564. PMID 30808745.
  34. ↑ Huang, Han-Yi; Liao, Hsin-Yu; Chen, Xiaorui; Wang, Szu-Wen; Wu, Chung-Yi; Jan, Jia-Tsrong; Cheng, Ting-Jen Rachel; Lin, Kuo-I; Ma, Che; Wong, Chi-Huey; et al. (2022-04-06). "Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models". Science Translational Medicine. 14 (639): eabm0899. doi:10.1126/scitranslmed.abm0899. PMC 9802656. PMID 35230146. S2CID 247168008.
  35. ↑ Tseng, Yung-Chieh; Wu, Chia-Yu; Liu, Ming-Liang; Chen, Ting-Hua; Chiang, Wan-Ling; Yu, Yueh-Hsiang; Jan, Jia-Tsrong; Lin, Kuo-I; Wong, Chi-Huey; Ma, Che (2019-03-05). "Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections". Proceedings of the National Academy of Sciences. 116 (10): 4200–4205. Bibcode:2019PNAS..116.4200T. doi:10.1073/pnas.1819197116. ISSN 0027-8424. PMC 6410868. PMID 30782805.
  36. ↑ Lin, Chin-Wei; Tsai, Ming-Hung; Li, Shiou-Ting; Tsai, Tsung-I.; Chu, Kuo-Ching; Liu, Ying-Chih; Lai, Meng-Yu; Wu, Chia-Yu; Tseng, Yung-Chieh; Shivatare, Sachin S.; Wang, Chia-Hung (2015-08-25). "A common glycan structure on immunoglobulin G for enhancement of effector functions". Proceedings of the National Academy of Sciences of the United States of America. 112 (34): 10611–10616. Bibcode:2015PNAS..11210611L. doi:10.1073/pnas.1513456112. ISSN 1091-6490. PMC 4553773. PMID 26253764.
  37. ↑ Lo, Hong-Jay; Krasnova, Larissa; Dey, Supriya; Cheng, Ting; Liu, Haitian; Tsai, Tsung-I; Wu, Kevin Binchia; Wu, Chung-Yi; Wong, Chi-Huey (2019-04-24). "Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing α2,6-Linked 3Fax-Neu5Ac". Journal of the American Chemical Society. 141 (16): 6484–6488. doi:10.1021/jacs.9b01991. ISSN 0002-7863. PMID 30969765. S2CID 108292858.
  38. ↑ Lin, Chih-Wei; Wang, Yu-Jen; Lai, Ting-Yen; Hsu, Tsui-Ling; Han, Shin-Ying; Han-Chung, Wu; Shen, Chia-Ning Shen; Chen, Ming-Wei; Chen, Lan-Bo; Wong, Chi-Huey; et al. (2021-12-14). "Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer". Proceedings of the National Academy of Sciences. 118 (50): e2114774118. Bibcode:2021PNAS..11814774L. doi:10.1073/pnas.2114774118. PMC 8685897. PMID 34876527.
  39. ↑ Loa, Lok-sin (31 March 2016). "Wong Chi-huey offers resignation". Taipei Times. Retrieved 25 April 2016.
  40. ↑ Normile, Dennis (11 May 2016). "Head of Taiwan's Academia Sinica resigns". Science Magazine. Retrieved 21 February 2018.
  41. ↑ Kao, Evelyn; Hsiao, Po-wen (21 February 2018). "Insider trading charges dropped against ex-Academia Sinica head". Central News Agency. Retrieved 22 February 2018.
  42. ↑ Lin, Liang-sheng; Chung, Jake (12 April 2022). "Wong Chi-huey deserves retrial, Control Yuan says". Taipei Times. Retrieved 12 April 2022.
  43. ↑ "Cotten Medal".
  44. ↑ "Academia Sinica President Chi-Huey Wong To Receive 2012 Arthur C. Cope Award". Asian Scientist Magazine. 2011-09-08. Retrieved 2019-10-23.
  45. ↑ Wolf Prize in Chemistry 2014
  46. ↑ "Academia Sinica President Chi-Huey Wong Receives 2015 Robert Robinson Award". www.genomics.sinica.edu.tw. Archived from the original on 2015-05-12. Retrieved 2019-10-23.
  47. ↑ Welch Award in Chemistry 2021
  48. ↑ Wu, Hsin-yun; Shih, Hsiu-chuan (12 April 2022). "Taiwanese biochemist Wong Chi-huey receives Chemical Pioneer Award". Central News Agency. Retrieved 13 April 2022. Republished as: "Biochemist receives US 'Pioneer' award". Taipei Times. 13 April 2022. Retrieved 13 April 2022.
  49. ↑ "EMBO recognizes 63 researchers for advances in life sciences". EMBO. Archived from the original on 2019-05-13. Retrieved 2019-10-23.
  50. ↑ , "Crystal structure of bifunctional transglycosylase PBP1b from E. coli and inhibitors thereof", issued 2015-12-04
  51. ↑ "Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants – Dimensions". app.dimensions.ai. Retrieved 2019-10-23.
  52. ↑ , "Antibiotic compositions and related screening methods", issued 2009-01-15
  53. ↑ , "Hirsutella sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses", issued 2010-03-30
  54. ↑ , "Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins", issued 2008-03-24
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