William Keen (1680s–1754) was a merchant and judicial officer in the British colony of Newfoundland.
William Keen or Keene may also refer to:
Entertainment
- William Keene (1915–1992), American TV actor
- Bill Keene (1927–2000), American television and radio personality
- Will Keen (born 1970), English actor
Other
- William Keen (cricketer) (1792–1846), English amateur cricketer
- William John Keen (1873–1958), Chief Commissioner of the North-West Frontier Province of British India
- William Williams Keen (1837–1932), pioneer American brain surgeon
See also
- William Keane (disambiguation)
- William Kean (1871–1954), British trade unionist
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