William Guest may refer to:
- William Guest (rugby union) (1903–1991), English player for Wakefield RFC, later a Territorial Army major
- William S. Guest (1913–1992), U.S. Navy rear-admiral
- William Guest (singer) (1941–2015), American R&B/soul singer, a member of Gladys Knight & the Pips
- William Guest (Reverend), English founder of Milton Mount College
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