Atlantic and Mediterranean

Carmick cleared San Diego, California on 19 February 1943 for Norfolk, Virginia, arriving on 10 March. Her varied and active career as an escort in the Atlantic began in April 1943 when she guarded a convoy to NS Argentia, Newfoundland, from which she returned to New York City to join the escort of a convoy bound for Casablanca. On 8 May she had her first enemy contact, delivering three depth charge attacks until being forced to break off the attack in order to rejoin the convoy. Returning to New York 1 June, Carmick stood north for training in Casco Bay. While running in a fog on 16 June, she struck a submerged object, which incident sent her back to Boston for four months of repairs.

Back in action 5 November 1943, Carmick crossed the Atlantic guarding a convoy to Derry, Northern Ireland in November, escorted Chikaskia to Aruba in December, and in January 1944 protected Hornet during the aircraft carrier's shakedown training off Bermuda. In February, she tested equipment for the Bureau of Ships and escorted Wasp to Trinidad. This phase of Carmick's contribution to the growing might of the Navy ended when the destroyer was assigned to hunter-killer operations with Destroyer Squadron 18 (DesRon 18) from 29 March.

On 2 April 1944, Carmick made two depth charge attacks with inconclusive results on an enemy submarine detected by sound contact. Later the same day, she successfully dodged a torpedo. On 18 April, Carmick cleared Boston for Plymouth, England, arriving 28 April to prepare for her role in the mighty naval force mounting the invasion of Europe. On 6 June (D-Day), she took station guarding the flanks of the leading ships off Omaha Beach, acting as antisubmarine and anti-E-boat screen. As the infantrymen began to move ashore, Carmick provided pin-point gunfire support, knocking out enemy strongpoints. She remained off the beachhead through 17 June, firing against enemy air attacks and guarding the great numbers of ships moving into the area to support forces ashore. On 10 June, she splashed a Heinkel bomber.

Screening duty in the English Channel preceded Carmick's departure for the Mediterranean on 18 July 1944. Convoy duty in connection with the buildup for the invasion of southern France continued until 15 August, day of the preliminary attacks on the coast between Toulon and Cannes. Once more Carmick was in the van of the invasion fleet, with duties similar to those she had at Normandy. Her constant vigilance was rewarded 18 August, when she destroyed an enemy E-boat. She supported the consolidation of the beachhead by convoy escort duty in the western Mediterranean until 23 September, when she cleared for New York City.

After overhaul and training, Carmick made three convoy escort voyages to Casablanca and Oran, guarding men and supplies for the European campaign. On 10 June 1945, she entered Philadelphia Navy Yard for conversion to a high speed minesweeper, and on 23 June 1945, she was reclassified DMS-33.