UNC84A

SUN1
Identifiers
Aliases	SUN1, UNC84A, Sad1 and UNC84 domain containing 1
External IDs	OMIM: 607723 MGI: 1924303 HomoloGene: 11544 GeneCards: SUN1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	896,435 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	139,235,595 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gastric mucosa; ; right uterine tube; ; bronchial epithelial cell; ; canal of the cervix; ; skin of abdomen; ; tibial nerve; ; popliteal artery; ; pituitary gland; ; left uterine tube;
	Top expressed in
	spermatocyte; ; spermatid; ; saccule; ; olfactory epithelium; ; superior frontal gyrus; ; ectoderm; ; otic placode; ; morula; ; secondary oocyte; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; lamin binding; protein-membrane adaptor activity;
Cellular component	cytoplasm; integral component of membrane; nuclear inner membrane; integral component of nuclear inner membrane; nuclear membrane; acrosomal membrane; intracellular membrane-bounded organelle; nucleus; membrane; meiotic nuclear membrane microtubule tethering complex; nuclear envelope;
Biological process	response to mechanical stimulus; homologous chromosome pairing at meiosis; nuclear envelope organization; nuclear matrix anchoring at nuclear membrane; ossification; spermatogenesis; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration; cell differentiation; meiosis; centrosome localization; meiotic attachment of telomere to nuclear envelope;
	Sources:Amigo / QuickGO
Orthologs
	23353
	77053
	ENSG00000164828
	ENSMUSG00000036817
	O94901
	Q9D666
	NM_025154; NM_001130965; NM_001171944; NM_001171945; NM_001171946
NM_001256115; NM_001256116; NM_001256117; NM_001256118; NM_024451;
	NM_001359494; NM_001359496
NP_001124437; NP_001165415; NP_001165416; NP_001165417; NP_079430;
	NP_001354562; NP_001354563; NP_001354564; NP_001354565; NP_001354566; NP_001354567; NP_001354568; NP_001354569; NP_001354570; NP_001354571; NP_001354572; NP_001354573; NP_001354574; NP_001354575; NP_001354576; NP_001354577; NP_001354578; NP_001354580; NP_001354582; NP_001354584; NP_001354587; NP_001354589; NP_001354591; NP_001354593; NP_001354594; NP_001354595; NP_001354596; NP_001354597; NP_001354598; NP_001354599; NP_001354600; NP_001354601; NP_001354602; NP_001354603; NP_001354604; NP_001354605; NP_001354606; NP_001354607; NP_001354608; NP_001354609; NP_001354610; NP_001354611; NP_001354612; NP_001354613; NP_001354614; NP_001354615; NP_001354616; NP_001354617; NP_001354618; NP_001354619; NP_001354620; NP_001354621; NP_001354622; NP_001354623; NP_001354624; NP_001354625; NP_001354626; NP_001354627; NP_001354628; NP_001354629; NP_001354630; NP_001354631; NP_001354632; NP_001354633; NP_001354634; NP_001354635; NP_001354637
NP_001243044; NP_001243045; NP_001243046; NP_001243047; NP_077771;
	NP_001346423; NP_001346425
	Wikidata
View/Edit Human	View/Edit Mouse

Protein unc-84 homolog A is a protein that in humans is encoded by the UNC84A gene.^[5]^[6]

This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164828 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036817 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dreger M, Bengtsson L, Schoneberg T, Otto H, Hucho F (Oct 2001). "Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane". Proc Natl Acad Sci U S A. 98 (21): 11943–8. Bibcode:2001PNAS...9811943D. doi:10.1073/pnas.211201898. PMC 59747. PMID 11593002.
1 2 "Entrez Gene: UNC84A unc-84 homolog A (C. elegans)".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Malone CJ, Fixsen WD, Horvitz HR, Han M (1999). "UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development". Development. 126 (14): 3171–81. doi:10.1242/dev.126.14.3171. PMID 10375507.
Bray JD, Chennathukuzhi VM, Hecht NB (2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics. 79 (6): 799–808. doi:10.1006/geno.2002.6779. PMID 12036294.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Schirmer EC, Florens L, Guan T, et al. (2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID 12958361. S2CID 23832536.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Padmakumar VC, Libotte T, Lu W, et al. (2005). "The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope". J. Cell Sci. 118 (Pt 15): 3419–30. doi:10.1242/jcs.02471. PMID 16079285.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Hasan S, Güttinger S, Mühlhäusser P, et al. (2006). "Nuclear envelope localization of human UNC84A does not require nuclear lamins". FEBS Lett. 580 (5): 1263–8. doi:10.1016/j.febslet.2006.01.039. PMID 16445915. S2CID 29434638.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Wang Q, Du X, Cai Z, Greene MI (2006). "Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome". DNA Cell Biol. 25 (10): 554–62. doi:10.1089/dna.2006.25.554. PMID 17132086.
Chi YH, Haller K, Peloponese JM, Jeang KT (2007). "Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes" (PDF). J. Biol. Chem. 282 (37): 27447–58. doi:10.1074/jbc.M703098200. PMID 17631499. S2CID 44621298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164828 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036817 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11593002-5] Dreger M, Bengtsson L, Schoneberg T, Otto H, Hucho F (Oct 2001). "Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane". Proc Natl Acad Sci U S A. 98 (21): 11943–8. Bibcode:2001PNAS...9811943D. doi:10.1073/pnas.211201898. PMC 59747. PMID 11593002.

[entrez-6] 1 2 "Entrez Gene: UNC84A unc-84 homolog A (C. elegans)".

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[5]

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References

Further reading