Before concurrency with US-34

US-6 runs east as Dodge Street in Omaha

US-6 enters Nebraska from Colorado west of Imperial on a short southeasterly segment. It turns east and stays due east until shortly before Imperial. It then goes into Imperial and meets Nebraska Highway 61 (N-61). The two routes are paired together until they separate at the Enders Reservoir State Recreation Area. It goes in a generally southeasterly direction until it meets US-34 west of Culbertson.^[1][2]

Western Nebraska

US-6 and US-34 continue east together through Culbertson and at McCook, is briefly concurrent with US-83. US-6/US-34 continue together in a northeasterly direction through Cambridge, then turns due east and meets US-283 in Arapahoe. Near Edison, it meets US-136, which begins at its intersection with US-6/US-34. Further east, the two highways meet N-4 and turns northeast toward Holdrege. In Holdrege, US-6/US-34 meet US-183. The highways continue on a northeasterly trajectory through Minden until Heartwell. At Heartwell, US-6/US-34 turns due east until Hastings. In Hastings, US-6/US-34 meet US-281 and US-34 separates to go with US-281 while US-6 continues eastward.^[1][2]

Eastern Nebraska

US-6 continues on a due east highway from Hastings. Near Sutton, the highway turns northeast to go through Sutton. It continues east, and, at Fairmont, US-6 encounters US-81. After passing through Friend, US-6 meets N-15, and the two highways overlap until shortly before Milford. US-6 goes east, then north out of Milford, then US-6 turns east to go toward Lincoln.^[1][2]

Lancaster County

In Lincoln, US-6 comes into the city on West "O" Street, portions of which are divided highway. At Sun Valley Boulevard, it turns to go northeasterly. At North 10th Street, US-6 turns north-northwest and becomes North 11th Street, a divided highway. At Cornhusker Highway, US-6 turns east with a short urban connection to I-180 on the west along Cornhusker. US-6 then follows Cornhusker Highway, which is a divided highway, northeast out of the city. At the eastern end of Cornhusker Highway (near Waverly), US-6 meets I-80.^[1][2]

Omaha

From I-80, US-6 goes northeast through Waverly, Greenwood, and Ashland. East of Ashland, US-6 crosses the Platte River. After that, US-6 meets N-31 in Gretna, where US-6 turns north with N-31 on a divided highway. US-6/N-31 meet US-275 and N-92 near the Elkhorn neighborhood of Omaha, and they separate in Elkhorn itself at a freeway interchange which also has Nebraska Link 28B, a connector to US-275.^[1][2]

At this point, US-6 goes onto the freeway, the West Dodge Expressway, and turns due east to go toward Fowntown Omaha. At 137th Street is the exit for Boys Town. Between 120th and 108th streets, US-6 is an elevated freeway with separate viaducts for eastbound and westbound traffic. Shortly after this ends, US-6 meets I-680. East of I-680, US-6 continues east as West Dodge Road and at Cass Street, turns briefly southeast where West Dodge Road ends, and follows Dodge Street eastward. Before North 30th Street, US-6 splits into two one-way streets, with Dodge Street serving westbound traffic, and Douglas Street serving the eastbound. US-6 goes through downtown and then goes up onto I-480, which is an elevated freeway around Downtown Omaha, and, shortly thereafter, crosses into Iowa via the Grenville Dodge Memorial Bridge.^[1][2]