Tittle is a surname. Notable people with the surname include:
- Ian Tittle (born 1973), West Indian cricket player
- LaDonna Tittle (born 1946), American radio personality, model and actress
- Minnie Tittle (1875–1974) American actress, better known under her stage name of Minnie Tittell Brune
- Steve Tittle (born 1935), Canadian composer and teacher
- Y. A. Tittle (1926-2017), American football quarterback
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