Second City or The Second City may refer to:
- Second city of the United Kingdom
- Chicago, nicknamed the Second City
- The Second City, an improvisational comedy troupe initially based in Chicago
- Mercenary: The Second City, a 1986 expansion pack for the video game Mercenary
- "Second City", an episode of 2007 Canadian/American TV series The Dresden Files
- Second City derby, Association-football rivalry between Aston Villa and Birmingham City
- Secondcity, stage name of American-born British musician Rowan Harrington (born 1987)
See also
- Second City Television, a Canadian television sketch comedy show that aired intermittently between 1976 and 1984
- Secondary city
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