Sts. Cyril and Methodius Church may refer to

In Slovenia:

• Sts. Cyril and Methodius Church (Ljubljana)

In Poland:

• Sts. Cyril and Methodius Church (Wrocław)

In Croatia:

• Greek Catholic Co-cathedral of Saints Cyril and Methodius, Zagreb

In Czechia:

• Saints Cyril and Methodius Cathedral, Prague

In the United States (by state):

• Sts. Cyril and Methodius Church (Hartford, Connecticut), listed in the National Register of Historic Places
• Sts. Cyril and Methodius Church (Shiner, Texas), listed in the National Register of Historic Places listings in Lavaca County, Texas