Serpa is a surname. Notable people with the surname include:
- Adhemar Serpa (1898–1978), Brazilian water polo player
- Enrique Serpa (1899/1900–1968), Cuban writer, see Cuban literature
- Horacio Serpa (born 1943), Colombian lawyer and politician
- Innocentius Serpa (1573–1625), Italian Roman Catholic bishop
- Ivan Serpa (1923–1973), Brazilian painter, draftsman, printmaker, designer and educator
- Jorge Enrique Serpa Pérez (born 1942), Cuban Roman Catholic bishop
- José Serpa (born 1979), Colombian road racing cyclist
- Louise Serpa (1925–2012), American rodeo photographer
- Marcello Serpa (born 1963), Brazilian advertising executive
- Patricia Serpa (born 1948), American politician
- Ronal W. Serpas (born c. 1961), American police chief
- Vasco Serpa (born 1971), Portuguese sport sailer
See also
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