Schieffelin is a surname, and may refer to:

• Bambi Schieffelin, a linguistic anthropologist at New York University in the department of Anthropology
• Bayard Schieffelin (1903–1989), an American philanthropist and director of the New York Public Library
• Bradhurst Schieffelin (1824–1909), an American political activist during the Civil War, who later became a member of the People's Party
• Ed Schieffelin (1847–1897), an Indian scout and prospector who discovered silver in the Arizona Territory, which led to the founding of Tombstone, Arizona
• Eugene Schieffelin (1827–1906), responsible for introducing the starling (Sturnus vulgaris) to North America
• George Richard Schieffelin (1836–1910), an American lawyer
• Hannah Lawrence Schieffelin (1758–1838), an American political poetess
• Henry Hamilton Schieffelin (1783–1865), an American businessman and lawyer
• Henry Maunsell Schieffelin (1808–1890), an American businessman, philanthropist and consul general in Liberia
• Jacob Schieffelin (1757–1835), an American loyalist, merchant, landowner and philanthropist
• John Jay Schieffelin (1897–1987), an American rear admiral and executive director of the English-Speaking Union
• Maunsell Schieffelin Crosby (1887–1931), an American ornithologist
• Richard Lawrence Schieffelin (1801–1889), an American lawyer and asset manager

• Samuel Schieffelin (1811–1900), an American author of religious tracts
• William Henry Schieffelin (1836–1885), an American businessman and Union Army cavalry officer in the American Civil War
• William Jay Schieffelin (1866–1955), an American businessman and philanthropist
• William Jay Schieffelin Jr. (1891–1985), an American businessman and philanthropist