Scherzer is a surname. Notable people with the surname include:
- Ernst Scherzer, German writer, pseudonym of Christian August Gottlob Eberhard (1769–1845)
- Johann Gottfried Scherzer, Austrian musical instrument maker (e.g. Contraguitar)
- Karl von Scherzer (1821–1903), Austrian explorer
- Max Scherzer (born 1984), American baseball pitcher
- Otto Scherzer (1909–1982), German theoretical physicist
- Steffi Scherzer (born 1957), German ballet dancer
- William Donald Scherzer (1858–1893), American engineer (known for the "Scherzer"-system of Bascule bridges)
- Julius Scherzer (born 1928), Romanian chemist
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