Santana is a surname of Spanish and Portuguese origin. The surname is prevalent in various Latin American countries. It is used by the following people:
- Adria Santana (1948–2011), Cuban actress
- Alencar Santana (born 1976), Brazilian politician
- Bianca Santana (born 1984), Brazilian writer, researcher, journalist and teacher
- Carlos Santana (born 1947), Mexican–American guitarist
- Dennis Santana (born 1996), pitcher in Major League Baseball
- Ervin Santana (born 1982), Major League Baseball Pitcher for the Minnesota Twins
- Johan Santana (born 1979), pitcher in Major League Baseball
- Jorge Santana (1951-2020), musician and brother of Carlos Santana
- Juelz Santana (born 1982), American rapper
- Lizé Santana (born 1980), American singer-songwriter
- Luan Santana (born 1991), Brazilian singer
- Manuel Santana (1938–2021), tennis player
- Salvador Santana (born 1983), musician and son of Carlos Santana
- Pedro Santana (1801–1864), first President of the Dominican Republic
- Rodrigão (Rodrigo Santana, born 1979), Brazilian volleyball player
- Tito Santana (born 1953), ring name of American professional wrestler Merced Solis
Football (soccer) players
- Cléber Santana (1981–2016), Brazilian footballer
- Fidelis Junior Santana da Silva (born 1981), Brazilian football midfielder
- Joel Santana (born 1948), former football player and coach for the South African national football team
- Jonathan Santana (born 1981), naturalized Paraguayan football midfielder
- Mario Santana (born 1981), Argentine football midfielder
- Pedro Aparecido Santana (born 1973), Brazilian football striker
- Rodrigo Marques de Santana (born 1982), Brazilian football midfielder
- Suso Santana (born 1985), Spanish football winger
- Telê Santana (1931–2006), a Brazilian football player and manager
- Vanesa Santana (born 1990), Argentine football midfielder
See also
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