Safiye is a Turkish feminine given name, a variant of the Arabic name Safiya. People named Safiye include:
- Safiye Ali (1891–1952), Turkish physician
- Safiye Ayla (1907–1998), Turkish singer
- Safiye Erol (1902–1964), Turkish novelist
- Safiye Sarıtürk Temizdemir (born 1995), Turkish sport shooter
- Safiye Sultan (wife of Murad III) (1550–1619), the spouse of Ottoman sultan Murad III and the mother of Sultan Mehmed III
- Safiye Sultan (daughter of Mustafa II) (1696–1778), the daughter of Ottoman sultan Mustafa II
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