SM4 or Sm4 may refer to:
- VR Class Sm4, a type of train operated by the VR Group
- SM4, a part of the SM postcode area, in Sutton, England
- HST-SM4, the final servicing mission to the Hubble Space Telescope
- SM4 (cipher), a block cipher used in the Chinese National Standard
- Standard Missile 4, a missile
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