SB-204070

SB-204070
Identifiers
	IUPAC name (1-butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate;
CAS Number	148688-01-1 ;
PubChem CID	121881;
IUPHAR/BPS	256;
ChemSpider	108731;
UNII	DQ39GL43SF;
ChEMBL	ChEMBL68131;
CompTox Dashboard (EPA)	DTXSID90164069 ;
Chemical and physical data
Formula	C19H27ClN2O4
Molar mass	382.89 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Nc1c2OCCOc2c(cc1Cl)C(=O)OCC3CCN(CCCC)CC3;
	InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3; Key:AOOSJYIINXVNHV-UHFFFAOYSA-N;

SB-204070 is a drug which acts as a potent and selective 5-HT₄ serotonin receptor antagonist (or weak partial agonist), and is used for research into the function of this receptor subtype.^[1]^[2]^[3]^[4]^[5]

References

↑ Mialet J, Berque-Bestel I, Sicsic S, Langlois M, Fischmeister R, Lezoualc'h F (October 2000). "Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells". British Journal of Pharmacology. 131 (4): 827–35. doi:10.1038/sj.bjp.0703641. PMC 1572397. PMID 11030734.
↑ Pindon A, van Hecke G, van Gompel P, Lesage AS, Leysen JE, Jurzak M (January 2002). "Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins". Molecular Pharmacology. 61 (1): 85–96. doi:10.1124/mol.61.1.85. PMID 11752209.
↑ Takahashi H, Takada Y, Urano T, Takada A (2002). "5-HT4 receptors in the hippocampus modulate rat locomotor activity". Hippocampus. 12 (3): 304–10. doi:10.1002/hipo.10012. PMID 12099482. S2CID 19746691.
↑ Sakurai-Yamashita Y, Yamashita K, Niwa M, Taniyama K (May 2003). "Involvement of 5-hydroxytryptamine4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia". Brain Research. 973 (1): 92–8. doi:10.1016/S0006-8993(03)02559-9. PMID 12729957. S2CID 22136959.
↑ Smith AJ, Chappell AE, Buret AG, Barrett KE, Dong H (December 2006). "5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury". FASEB Journal. 20 (14): 2486–95. doi:10.1096/fj.06-6391com. PMID 17142798. S2CID 27119792.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[pmid11030734-1] Mialet J, Berque-Bestel I, Sicsic S, Langlois M, Fischmeister R, Lezoualc'h F (October 2000). "Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells". British Journal of Pharmacology. 131 (4): 827–35. doi:10.1038/sj.bjp.0703641. PMC 1572397. PMID 11030734.

[pmid11752209-2] Pindon A, van Hecke G, van Gompel P, Lesage AS, Leysen JE, Jurzak M (January 2002). "Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins". Molecular Pharmacology. 61 (1): 85–96. doi:10.1124/mol.61.1.85. PMID 11752209.

[pmid12099482-3] Takahashi H, Takada Y, Urano T, Takada A (2002). "5-HT4 receptors in the hippocampus modulate rat locomotor activity". Hippocampus. 12 (3): 304–10. doi:10.1002/hipo.10012. PMID 12099482. S2CID 19746691.

[pmid12729957-4] Sakurai-Yamashita Y, Yamashita K, Niwa M, Taniyama K (May 2003). "Involvement of 5-hydroxytryptamine4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia". Brain Research. 973 (1): 92–8. doi:10.1016/S0006-8993(03)02559-9. PMID 12729957. S2CID 22136959.

[pmid17142798-5] Smith AJ, Chappell AE, Buret AG, Barrett KE, Dong H (December 2006). "5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury". FASEB Journal. 20 (14): 2486–95. doi:10.1096/fj.06-6391com. PMID 17142798. S2CID 27119792.

[1]

[2]

[3]

[4]

[5]