2011–2017: Beginnings and Free 6lack

6lack in January 2017

6lack signed a record deal with Flo Rida's International Music Group and Strong Arm Records in July 2011. He left Valdosta State University once he signed, and spent the next few years learning about the industry. 6lack spent five years with the label, putting music out on his SoundCloud account. 6lack had little financial security and spent most of his time sleeping in the studio or outside on the street after moving to Miami, Florida to work on music with the record label.^[11] 6lack eventually left his label due to issues over artistic and creative license and management.^[12] In 2015, 6lack announced that he had joined the musical collective Spillage Village after living with the members of EarthGang, and appeared on four tracks of Spillage Village EP called Bears Like This Too in 2015.^[13]

Once he left the label, he signed with Love Renaissance and Interscope Records.^[14] In November 2016, Rolling Stone included 6lack in their list of "10 New Artists You Need to Know".^[3] He then went on to release his debut studio album, Free 6lack, which peaked at number 34 on the Billboard 200 chart.^[15] The album's single "Prblms" peaked at number 73 on the Billboard Hot 100 chart and became his first platinum record.^[16] In April 2017, he joined Canadian singer The Weeknd as opening act for his Legend of the Fall tour in North America.

2018–present: East Atlanta Love Letter, 6pc Hot, and Since I have a lover

In April 2018, he released the single "OTW" with Khalid and Ty Dolla Sign, which has reached at number 57 on the Billboard Hot 100.^[17] "OTW" became 6lack's highest peaking song on the Hot 100.^[17] The first single for his sophomore album, "Switch", was released on June 22, 2018, with a music video released on July 16.^[18] "Nonchalant" was released as the album's second single on August 17, with its accompanying music video.^[19][20] On September 14, 2018, 6lack released his second studio album, East Atlanta Love Letter, featuring guest appearances from Future, J. Cole, Offset, and Khalid. The album's release was preceded by the singles "Switch" and "Nonchalant."^[21] In October 2018, 6lack started a tour for the promotion of the album, with opening acts THEY., Tierra Whack, Boogie, Deante' Hitchcock, Summer Walker, and Ari Lennox.^[22][23] 6lack later featured on several other songs, such as "Waves" by Normani.^[24] and "Crowded Room" by Selena Gomez, in 2019 and early 2020, respectively.^[25] In May 2020, 6lack released the track "ATL Freestyle". A few weeks later, on June 24, 2020, 6lack celebrated his birthday with the release of the single "Float". He also announced his EP 6pc Hot, which was released on June 26 and included the Lil Baby-assisted single, "Know My Rights". He also launched his own hot sauce brand 600 Degrees Original.^[26] 6lack appeared on two tracks from Spillage Village's Spilligion album, released in September 2020.^[27] During 2020, he collaborated with British virtual band Gorillaz and singer-songwriter Elton John on the track "The Pink Phantom", for the band's seventh studio album, Song Machine, Season One: Strange Timez.

In 2021, he released "Calling My Phone" with Bronx rapper Lil Tjay.^[28] In 2022, he was featured on Canadian singer-songwriter Jessie Reyez's album Yessie, in her song "Forever", and its accompanying music video.^[29]

On March 24 2023, 6lack released his album Since I have a Lover, this was 19 tracks and had features from QUIN, Wale, and Don Toliver. In an interview with complex 6lack stated that he came out with the album name to address questions such as “Where have you been? What have you been doing? What’s the inspiration?” And to those questions he would respond "Since I have a lover".