Quintanilla is a Spanish surname. Notable people with the surname include:

• Abraham Quintanilla, Jr. (born 1939), American singer-songwriter and record producer, father of Selena Quintanilla-Pérez
• A.B. Quintanilla (Abraham Quintanilla III) (born 1963), American singer-songwriter and record producer, brother of Selena Quintanilla-Pérez
• Alba Quintanilla, Venezuelan composer, harpist, harpsichordist, pianist, conductor, and pedagogue
• Antonio de Quintanilla (1787–1863), Spanish brigadier and Governor of Chiloé
• Armando Quintanilla (born 1968), Mexican long-distance runner
• Beto Quintanilla (1948–2007), Mexican singer, songwriter and musician
• Carl Quintanilla (born 1970) is an American journalist and CNBC anchor
• Carlos Quintanilla (1888–1964), President of Bolivia
• Diego Quintanilla (born 1991), Ecuadorian footballer
• Eleuterio Quintanilla (1886–1966), Spanish anarchist and educator
• Eliseo Quintanilla (born 1983), Salvadoran footballer
• Enrique Perea Quintanilla (1956–2006), Mexican journalist, crime reporter, and magazine founder
• Fernando Quintanilla (born 1964), Spanish footballer also known as Txirri
• Francisco Javier Quintanilla (1833-?), Chilean priest
• Hector Quintanilla (1923–1998), United States Air Force Lieutenant Colonel
• Isabel Quintanilla (1938–2017), Spanish visual artist
• José Quintanilla (footballer) (1947–1977), Salvadoran footballer
• José Alberto Quintanilla (born 1997), Bolivian swimmer
• María José Quintanilla (born 1990), Chilean singer, songwriter, and actress
• Mauricio Quintanilla (disambiguation), multiple people, including:
  • Mauricio Quintanilla (footballer, born 1952) (born 1952), Salvadoran football forward
  • Mauricio Quintanilla (footballer, born 1981) (born 1981), Salvadoran football defender
• Omar Quintanilla (born 1981), American baseball player
• Rolando Quintanilla (born 1977), Mexican racing driver
• Selena Quintanilla-Pérez (1971–1995), American singer, songwriter, spokesperson, actress, and fashion designer