Mayor

Adam West was the mayor of Quahog until the death of his namesake voice actor. He appeared on a recurring basis from his first appearance in season 2 until his final appearance in season 17. Quahog's current mayor is Mayor West's cousin, Wild Wild West, voiced by Sam Elliott, who was introduced in the episode "Wild Wild West".

News anchors

The town's local "celebrities" are Tom Tucker, an arrogant, baritone-voiced news anchor at Channel 5, and Diane Simmons, the station's 40-year-old former news co-anchor who was killed off in "And Then There Were Fewer". The two work alongside Tricia Takanawa, a stereotypical Asian reporter who speaks with a nasal monotone cadence; and Blaccu-Weather meteorologist Ollie Williams, a fast-talking chubby African-American man who rarely speaks for more than about 1–2 seconds.

The Drunken Clam

The Drunken Clam is a bar owned by Jerome and formerly Horace (who died in "Save the Clam") that Peter frequently visits along with his friends: Joe Swanson, a paraplegic police officer; former deli owner turned mailman Cleveland Brown and sex-crazed airline pilot bachelor Glenn Quagmire. The Drunken Clam is easily recognized by its animated neon sign on the roof at the front of the building. It depicts a clam swigging from a bottle and becoming intoxicated, judging by the "xx" eyes and the bubbles rising.

The Drunken Clam is also known as the location in which any of the group's schemes and adventures are hatched or take place. Peter works as an assembly worker in a toy factory in early episodes but is a self-employed fisherman and an employee of the fictitious Pawtucket Brewery in later episodes. Peter entertains the Clam's patrons on the piano while drunk in "Wasted Talent".

In "One if by Clam, Two if by Sea",^[5] after a hurricane, The Drunken Clam became "The Clam's Head Pub", much to Peter and the guys' disgust, as new owner Brit Nigel Pinchley took over. Despite their best efforts of them to claim back the bar, the Brits had convinced them to leave. However, after Pinchley burned down the Clam's Head Pub as an insurance fraud, and his subsequent arrest and execution, Horace returned from Florida, having had an alligator lay eggs in his lower intestine and getting into a knife-fight with his mother, losing a testicle in the process. The Clam was rebuilt by Horace, Peter and the gang and began running again. The episode reveals that Peter has been going to the Clam since at least 1977.

In "Blind Ambition",^[6] Peter falls off its roof and kills Joan Cusack. Also, in that same episode, the bar burns to the ground when God tries to impress a woman by lighting her cigarette with a thunderbolt. God and Jesus escape by driving away in their Cadillac Escalade, but a blind Peter, without realizing it, rescues Horace from the inferno and becomes a local hero. The Drunken Clam becomes a Karaoke Bar in "Don't Make Me Over", as the gang helps Horace to put the bar back on its feet against the competition from a new shopping mall. Other renovation attempts, including the original theme to the film Coyote Ugly, had previously failed.

As seen in "Stewie B. Goode", Brian takes Stewie to the Clam in an effort to persuade him of the dangers of alcohol. Brian is unsuccessful in his attempt, and is so drunk that he is unable to drive, giving an equally intoxicated Stewie his car keys. Stewie crashes Brian's Prius through the wall of the bar, an event shown on the news by Tom Tucker in an attempt to expose Peter. In "Meet the Quagmires", Death shows up when Horace falls off his ladder in the Clam, while trying to fix the TV—Horace is only knocked unconscious. This allows Peter to ask Death to return him to the 1980s, so he can live a wild youth. Part of that experience includes visiting the 1980s bar—then called "St. Elmo's Clam"—a reference to the electrical phenomenon and to the song and movie. "St Elmo's Fire". Here Peter plays "Menstrual Ms. Pac-Man", meets and makes out with actress Molly Ringwald, and joins Cleveland at an evening disco. This contradicts the bar's appearance in "One if by Clam, Two if by Sea", where in the same year, it was still The Drunken Clam. The Clam's back room, complete with a table tennis table, is seen in "Hell Comes to Quahog", in which Joe becomes competitive and beats Peter, Cleveland and Quagmire at table tennis.

In the sixth season episode "Believe It or Not, Joe's Walking on Air",^[7] the guys' significant others, Lois, Bonnie and even Muriel, wife of recurring character and Jewish pharmacist Mort Goldman, as well as Cleveland's girlfriend at the time, Bernice, begin hanging out at the Clam, forcing the guys to open the Quahog Men's Club. The guys were able to reclaim the Clam soon after. Due to Cleveland's absence from Family Guy, Peter, Quagmire and Joe meet their new black friend, Jerome, in "Jerome Is the New Black". However, the vacancy reopens at the end of the episode. In "Back to the Pilot",^[8] it is revealed that if Frank Sinatra had never been born, The Clam would be long abandoned as of 2009 in the Apocalyptic Universe, as it is seen in shambles. Horace dies in "Save the Clam", leaving the guys to try to find a way to save the bar from foreclosure. Eventually, Jerome shows up and reveals he bought the Clam with his sports earnings, allowing it to stay open.

In "Finders Keepers", a waiter tells Stewie that his placemat is a real treasure map, then tells a probably false story about Miles "Chatterbox" Musket which impresses Peter, despite Lois's insistence that it is a joke. Refusing to give up, Peter and Lois search leads them to The Drunken Clam. Behind a painting of legendary Quahog founder Miles "Chatterbox" Musket, they find a treasure chest containing an expired restaurant coupon for a free meal which was a promotion by The Founding Father Restaurant. The Clam is parodied as "Ye Soused Mackerel" in the Romeo and Juliet segment of "Heart Burn".