Pyrimidine biosynthesis occurs both in the body and through organic synthesis.[1]

[2]</ref>==De novo biosynthesis of pyrimidine ==

Steps Enzymes Products
1 carbamoyl phosphate synthetase II[3]carbamoyl phosphateThis is the regulated step in the pyrimidine biosynthesis in animals.
2 aspartic transcarbamoylase (aspartate carbamoyl transferase)[3]carbamoyl aspartic acidThe phosphate group is replaced with Aspartate. This is the regulated step in the pyrimidine biosynthesis in bacteria.
3 dihydroorotase[3]dihydroorotateRing formation and Dehydration.
4 dihydroorotate dehydrogenase[4] (the only mitochondrial enzyme)orotateDihydroorotate then enters the mitochondria where it is oxidized through removal of hydrogens. This is the only mitochondrial step in nucleotide rings biosynthesis.
5 orotate phosphoribosyltransferase[5]OMPPRPP donates a Ribose group.
6 OMP decarboxylase[5]UMPDecarboxylation
uridine-cytidine kinase 2[6]UDPPhosphorylation. ATP is used.
nucleoside diphosphate kinaseUTPPhosphorylation. ATP is used.
CTP synthaseCTPGlutamine and ATP are used.

De Novo biosynthesis of a pyrimidine is catalyzed by three gene products CAD, DHODH and UMPS. The first three enzymes of the process are all coded by the same gene in CAD which consists of carbamoyl phosphate synthetase II, aspartate carbamoyltransferase and dihydroorotase. Dihydroorotate dehydrogenase (DHODH) unlike CAD and UMPS is a mono-functional enzyme and is localized in the mitochondria. UMPS is a bifunctional enzyme consisting of orotate phosphoribosyltransferase (OPRT) and orotidine monophosphate decarboxylase (OMPDC). Both, CAD and UMPS are localized around the mitochondria, in the cytosol.[7] In Fungi, a similar protein exists but lacks the dihydroorotase function: another protein catalyzes the second step.

In other organisms (Bacteria, Archaea and the other Eukaryota), the first three steps are done by three different enzymes.[8]

Pyrimidine catabolism

Pyrimidines are ultimately catabolized (degraded) to CO2, H2O, and urea. Cytosine can be broken down to uracil, which can be further broken down to N-carbamoyl-β-alanine, and then to beta-alanine, CO2, and ammonia by beta-ureidopropionase. Thymine is broken down into β-aminoisobutyrate which can be further broken down into intermediates eventually leading into the citric acid cycle.

β-aminoisobutyrate acts as a rough indicator for rate of DNA turnover.[9]

Regulations of pyrimidine nucleotide biosynthesis

Through negative feedback inhibition, the end-products UTP and UDP prevent the enzyme CAD from catalyzing the reaction in animals. Conversely, PRPP and ATP act as positive effectors that enhance the enzyme's activity.[10]

Pharmacotherapy

Modulating the pyrimidine metabolism pharmacologically has therapeutical uses, and could implement in cancer treatment.[11]

Pyrimidine synthesis inhibitors are used in active moderate to severe rheumatoid arthritis and psoriatic arthritis, as well as in multiple sclerosis. Examples include Leflunomide and Teriflunomide (the active metabolite of leflunomide).

Prebiotic synthesis of pyrimidine nucleotides

In order to understand how life arose, knowledge is required of the chemical pathways that permit formation of the key building blocks of life under plausible prebiotic conditions. The RNA world hypothesis holds that in the primordial soup there existed free-floating pyrimidine and purine ribonucleotides, the fundamental molecules that combine in series to form RNA. Complex molecules such as RNA must have emerged from relatively small molecules whose reactivity was governed by physico-chemical processes. RNA is composed of pyrimidine and purine nucleotides, both of which are necessary for reliable information transfer, and thus natural selection and Darwinian evolution. Becker et al. showed how pyrimidine nucleosides can be synthesized from small molecules and ribose, driven solely by wet-dry cycles.[12]

References

  1. ↑ Alqahtani, Saad Saeed; Koltai, Tomas; Ibrahim, Muntaser E.; Bashir, Adil H. H.; Alhoufie, Sari T. S.; Ahmed, Samrein B. M.; Molfetta, Daria Di; Carvalho, Tiago M. A.; Cardone, Rosa Angela; Reshkin, Stephan Joel; Hifny, Abdelhameed; Ahmed, Mohamed E.; Alfarouk, Khalid Omer (6 July 2022). "Role of pH in Regulating Cancer Pyrimidine Synthesis". Journal of Xenobiotics. 12 (3): 158–180. doi:10.3390/jox12030014. PMC 9326563.
  2. ↑ <?xml version="1.0" encoding="utf-8" ?> <kml xmlns="http://www.opengis.net/kml/2.2"> <Document id="root_doc"> <Folder><name>Indiana_State_Road_26</name> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-87.09274334076494,40.445992496558311 -87.083376342729537,40.445867829470771 -87.078605945249436,40.445826711645601 -87.073417657037211,40.445749041102154 -87.067109122433607,40.445667288893233 -87.059779450390479,40.44550464300869 -87.0562874575715,40.44544333225182 -87.054253326648251,40.445453313879469 -87.050382601331776,40.445581193118123 -87.045647110388444,40.445745323874505 -87.039322572717495,40.445968371275505 -87.038243606859623,40.446004769675682 -87.036777664913018,40.446018758998669 -87.035599908536128,40.446001109473528 -87.034446835615114,40.445938395065241 -87.033018192426354,40.445900523233284 -87.028161670476223,40.44583757248887 -87.027965566552538,40.445837620094494 -87.026392466779228,40.446080200666501 -87.025709322207945,40.446179409733716 -87.02519854309206,40.446184026751716 -87.024613675774958,40.446098566249169 -87.020963670506461,40.445478962818129 -87.018527061864134,40.445032302028743 -87.018125293047461,40.444979978656917 -87.01689073404637,40.445010120011624 -87.016234289495486,40.445085079747194 -87.014960567272652,40.445332281333322 -87.014215929840645,40.445489540080303 -87.013266869347859,40.445638887851317 -87.01256402046458,40.445750228846137 -87.011819357105566,40.445817695498413 -87.010898335250772,40.445855219734646 -87.009185107317109,40.445850277505087 -87.005568387620244,40.445867625593223 -87.003528458088624,40.44587775190913 -87.00290406105573,40.445887724343692 -86.999330793246799,40.445893975166598 -86.998004525562848,40.445898464434627 -86.996481860640685,40.445866896249974 -86.989928370167291,40.445758401770881 -86.984772627888702,40.445627205572087 -86.981039023760857,40.44554557152523 -86.980272399627253,40.445203322388814 -86.976174771209443,40.443373476139911 -86.970994283822932,40.441084337361474 -86.967919690457862,40.439718284662895 -86.966432176711251,40.439019655776015 -86.963955858924322,40.437978357105195 -86.961911007775825,40.437090303215243 -86.959918222262857,40.436179708285643 -86.958014548601881,40.435390734424217 -86.955493333543117,40.434264145472433 -86.954453108075683,40.433799275809506 -86.952467803597699,40.432924591417652 -86.951144432424528,40.432369978453579 -86.950675981163684,40.432104010283517 -86.950185474386572,40.431774966805236 -86.947858781685639,40.429931573870249 -86.946595554806208,40.428953506458903 -86.944127959091489,40.427091954132344 -86.943362510386422,40.426524006131508 -86.942649062729515,40.425956078815972 -86.941519302260247,40.424991535129678 -86.940875922385416,40.424476334712445 -86.940713126777553,40.424338817825145 -86.940595247851221,40.424265782386016 -86.940353612079633,40.424235613399681 -86.939960425320095,40.424216850159262 -86.939565807260323,40.424219617578622 -86.939179734618989,40.424222344001905</coordinates></LineString><LineString><coordinates>-86.822189177433074,40.417552461844679 -86.820933197637657,40.417534554778399 -86.820906598406282,40.417534175737281 -86.820563946291529,40.417533645374192 -86.820536422050438,40.417533602655247 -86.820325918737339,40.417527374738071 -86.819379593651988,40.417500269273624 -86.81662819245193,40.417467604617237 -86.815356496377817,40.417457877935725 -86.814924084342721,40.417457186579185 -86.81396942256066,40.417505564257674 -86.812873309751765,40.417512445133724 -86.811791786745545,40.417528707976366 -86.810727527289444,40.417567511821467 -86.809974936904979,40.417579791092862 -86.80932028332991,40.417638668252401 -86.804719175290913,40.417726215299005 -86.802052898218165,40.417746006873116 -86.799246232195088,40.4177463479595 -86.798675287032026,40.417736346071543 -86.795443767910783,40.417730674043028 -86.794777791368531,40.417729493882526 -86.790239193200648,40.417739861878069 -86.789595451218986,40.417733693030719 -86.788370788558765,40.417817044768519 -86.787094213067775,40.418008397634125 -86.78463123816725,40.418512852435207 -86.781181111388477,40.419227105403948 -86.779042500277114,40.41965998131306 -86.778418930827499,40.419787483464866 -86.77694731407918,40.420088396826678 -86.775824229713166,40.42030577645906 -86.775402135837879,40.420387211593322 -86.774895779236999,40.420444786233887 -86.774476151411392,40.42045748218316 -86.774060681774188,40.420443157329615 -86.773658594198636,40.420392820640444 -86.773256552598767,40.420328968940169 -86.772979830493213,40.420260857408536 -86.772604081884978,40.420143000249787 -86.770902066226384,40.419445936797686 -86.768089588602251,40.418269141914479 -86.767489290813572,40.418020184987526 -86.766979316573241,40.417847984686567 -86.766430541836414,40.417734263159034 -86.766045772117451,40.417692944109447 -86.765396852657489,40.417651088102595 -86.764743643974896,40.417690301974147 -86.764124503241831,40.417779131921762 -86.763522773577137,40.417944571836763 -86.762959529214783,40.418159637777521 -86.761920040344677,40.41868453650968 -86.761159638145344,40.419016306269214 -86.760384457551424,40.419275967291853 -86.759948704310631,40.419383173023114 -86.759351551158787,40.419481032152163 -86.757910898073845,40.419491538335208 -86.757188404476608,40.419517050697458 -86.756688200380694,40.419615188815641 -86.755993658724506,40.419766791221264 -86.755219101682187,40.419846236190743 -86.751870627217954,40.419852612265387 -86.750404166292412,40.41985846494741 -86.748925455745606,40.419814136601062 -86.747339267163284,40.419716400636979 -86.745802338184092,40.419623210745968 -86.74383232594964,40.419533275987881 -86.742592162570261,40.419516107008789 -86.741511418384192,40.419501083074593 -86.735796840284678,40.419357533455496 -86.734704299425658,40.419165839934841 -86.73356049899219,40.418807349011587 -86.732754666160773,40.418490664138893 -86.731881367118845,40.418186341705862 -86.731098509612153,40.417950286154543 -86.730077788786502,40.417758715911773 -86.729149767940044,40.417702490869793 -86.724652270224311,40.417691867667912 -86.714872814173816,40.417704201084128 -86.708890010961554,40.417720824311928 -86.70415526395881,40.417704301631545 -86.699936187393277,40.417706942761491 -86.69460266684753,40.417661445983327</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-87.092743432765644,40.446031119417007 -87.092761789779303,40.44603117676138 -87.093512308265673,40.446033500057936 -87.094813366577782,40.446050322474541 -87.096647984189687,40.446080966639919 -87.098646402473804,40.446115044772135 -87.101323448618047,40.44613777471487 -87.102413333499129,40.446157908236778 -87.102615146719188,40.446161635621245 -87.10412687756272,40.446178166922579 -87.105498093579797,40.446187643633785 -87.107108136549158,40.446218371564548 -87.107978631127764,40.446249724261321 -87.108877222125543,40.446263159973057 -87.109925569124016,40.446272934647368 -87.110903770148994,40.446293441115969 -87.113253173414265,40.446312605913548 -87.115017629872014,40.446335908266548 -87.116356163820555,40.446366731261534 -87.117582346663951,40.446379815062805 -87.118640077563668,40.446393014713244 -87.119416976419402,40.446406539268096 -87.121139260584869,40.446419025862134 -87.122810059172522,40.446424425213422 -87.124377931341584,40.446440632934326 -87.126076802823377,40.446449512558573 -87.127312323096916,40.446440997161922 -87.128627461171135,40.446443099029935 -87.130195248446853,40.446444947618787 -87.131145326224598,40.446461756779804 -87.132876960228515,40.446459779367451 -87.13451031980064,40.44646500849732 -87.135970539224388,40.446484786939919 -87.13658371288318,40.446530551072897 -87.137229611622033,40.446547624167351 -87.137781909374567,40.446579173865352 -87.138147107956456,40.446632342178418 -87.138488847845395,40.446689141983668 -87.138839985339416,40.446756694466558 -87.139191175013991,40.446849201028655 -87.139453436713751,40.446934696641733 -87.139673607840919,40.447023845259956 -87.139921867525928,40.447123637049039 -87.140704115144274,40.447462375716114 -87.140952392922955,40.447569326594383 -87.141191287850035,40.44767272890202 -87.141359923202501,40.447729730597395 -87.141589392911953,40.447808099208679 -87.141837575731586,40.447868606388305 -87.142029602810837,40.447918416167816 -87.142212168423058,40.447953958746496 -87.142474317424174,40.447982238945499 -87.142750507276375,40.448014060707379 -87.142989256108393,40.448045928126319 -87.143139095380576,40.448052904925198 -87.143312217375211,40.448056294975402 -87.144660132982679,40.448068895523349 -87.145203076557252,40.448075377062153 -87.145745977817356,40.448088972391204 -87.146279554291894,40.448099019277166 -87.146714824638522,40.448102071318189 -87.147168876300199,40.448119377233049 -87.147543359755417,40.448151062365994 -87.147899030704366,40.448154167369061 -87.14836712406273,40.448175054250832 -87.148966256527459,40.448206446233847 -87.149658987372902,40.448248478947406 -87.150351777933281,40.44829046328686 -87.15134881498561,40.448357091739936 -87.152879414367675,40.448451610189302 -87.15337092884198,40.448476003523346 -87.153623668636513,40.448486389659514 -87.15405427364594,40.44851086191543 -87.154251777563132,40.448521520275904 -87.15470023646472,40.448545720352413 -87.155453891324868,40.448591196283068 -87.156493020893947,40.448650605661456 -87.157396402195062,40.448702982425857 -87.158763268298586,40.448794087177546 -87.159896105219048,40.448881896063718 -87.160303333156605,40.448917099095759 -87.160645143793431,40.448966670134908 -87.160930722066055,40.449023479788949 -87.161178867919816,40.449058901086715 -87.161413030833643,40.449115782124032 -87.161764255100536,40.449204706455653 -87.161937577058538,40.449265229240908 -87.162471604114586,40.449457544842922 -87.163038376531546,40.449656974022481 -87.164237621576319,40.45010577711475 -87.165357233951909,40.450511796571391 -87.165642934422664,40.450590082878222 -87.165877071168353,40.450632630432288 -87.166036175935261,40.450639564249514 -87.166214072876087,40.450639308600138 -87.16642465118862,40.450621122581666 -87.1674072107851,40.450512449702707 -87.167954682672956,40.450458006431788 -87.168230760811412,40.450436164249716 -87.168530238725225,40.450410681857718 -87.168881174705803,40.450378007243167 -87.169143303298611,40.450366903180175 -87.169438117239096,40.450362867803612 -87.170636351273075,40.450389710088373 -87.171567819976616,40.450413375784919 -87.172237114191034,40.450430264468523 -87.172845625277517,40.450450796965598 -87.173299634759758,40.450442955010629 -87.173725536437928,40.450442315745647 -87.174380751619339,40.450441329224482 -87.175358937974678,40.450425571001468 -87.177614762061538,40.450382802351214 -87.179313661041547,40.450362295637461 -87.180310574868059,40.450360744975754 -87.182173266198532,40.450336383852012 -87.182711596736169,40.45033281530629 -87.183591402562641,40.450326978102154 -87.186741127575246,40.450286165944874 -87.188004816246107,40.45029127990184 -87.188393303211782,40.450279927521343 -87.189671034185579,40.450288558068756 -87.191098535182093,40.450296928807809 -87.192680543823755,40.45031218581871 -87.194922504124364,40.450333427450971 -87.196668338513035,40.450355514858238 -87.197464015841163,40.450357717042827 -87.198657499386471,40.450369996674922 -87.200234831578555,40.450377997010861 -87.201784048762022,40.450389627638522 -87.202710767171936,40.450398727125375 -87.203066478523127,40.450390940593962 -87.203286394547732,40.450383391847659 -87.20352505049425,40.450372251100376 -87.203754325215414,40.450339684760245 -87.20396948556089,40.450299980643038 -87.204226794277332,40.450256597133844 -87.204619638765436,40.45016653226277 -87.205353895563505,40.449982842108582 -87.205648591178687,40.449921551012842 -87.205938578818888,40.449863827044688 -87.20624731650949,40.44980606979864 -87.206439345714429,40.449788006150484 -87.206518710020049,40.449780540003538 -87.206729237465836,40.449769441988565 -87.207141089719613,40.449765146146682 -87.208718430439546,40.449780192046248 -87.210005573316337,40.449802861155696 -87.211685832847195,40.449806958733326 -87.212916739352039,40.44981541898396 -87.214002583458608,40.449820577071712 -87.215163311921259,40.449825584703575 -87.216862309777611,40.449825968524841 -87.218589283043187,40.449815553662873 -87.220054181996645,40.449812774402588 -87.222562815394582,40.449793691507878 -87.223419277929366,40.449795598000676 -87.225174397457636,40.449792192587736 -87.226826482847684,40.449781846462677 -87.228235223587149,40.449771911482806 -87.228562861529099,40.449764101922909 -87.228806132652991,40.449742178143673 -87.229077492809438,40.449709434134142 -87.229259888595166,40.449680467790401 -87.229489136203696,40.449644291879025 -87.230307568958537,40.449474600578064 -87.231233601354546,40.449268965459659 -87.231476845232436,40.449239875690239 -87.231771610491236,40.449207076686072 -87.232099100268798,40.449174258079218 -87.232361142929435,40.449159407210452 -87.232641960650525,40.449151724336119 -87.233152172970364,40.44916857947274 -87.234383094162709,40.449183928307349 -87.235213649694558,40.449201323508639 -87.235628145691848,40.449210001996221 -87.237603307668692,40.449241724352355 -87.239873321758765,40.449265641088786 -87.240149434577702,40.449261509231128 -87.240626911907228,40.449274794837308 -87.240875021988316,40.449288602572764 -87.241155882299694,40.449309459540572 -87.241436801738345,40.449330313900468 -87.242251556405179,40.449443025704937 -87.243487769288961,40.449615654361644 -87.244204212243488,40.449721397198623 -87.244410276258648,40.449749564660223 -87.244625630761988,40.44977055167201 -87.244723949390163,40.44977750579978 -87.24495805456543,40.449798450693862 -87.245955073226654,40.44982854209416 -87.247078569907586,40.449890470229391 -87.248450182810245,40.449966225749165 -87.248712303800829,40.449972778374814 -87.249142976353326,40.450004059373128 -87.249470687168753,40.45003195557193 -87.249807812051145,40.45007055221209 -87.250187255820279,40.450151985485036 -87.25050122515735,40.450258557821869 -87.250805673975478,40.450325827101061 -87.250960333241707,40.450371977431566 -87.251030500751185,40.45037182508112 -87.251170953697084,40.450371519996231 -87.251912314873749,40.45036664643267 -87.252799638403147,40.45036080756261 -87.253145039320231,40.450361620189561 -87.254376959649122,40.450364509664766 -87.254361503835312,40.451276589182555 -87.254344691260457,40.452268695616695 -87.254296801455624,40.453830525220219 -87.254376182691971,40.453818009028147 -87.254463514428053,40.453817816819367 -87.255071218483636,40.453750710308583 -87.255433067490543,40.453721610184331 -87.255754269183839,40.45369577726813 -87.256222135621442,40.453653660687444 -87.257179526791063,40.453589867518396 -87.258013203476224,40.453526387661469 -87.258889786469723,40.453442219960891 -87.259384612753692,40.453404127529744 -87.259621211082489,40.453378957463507 -87.259787885791056,40.453341554788963 -87.260008263463305,40.453299978811224 -87.260443504539666,40.453163367324997 -87.262163195237733,40.452670422119169 -87.262367439387702,40.452620633118798 -87.262555590504263,40.452587323684988 -87.262733105730732,40.452578722099986 -87.263012809264964,40.452569887786233 -87.264250122768615,40.452558821788287 -87.265600409312441,40.452531088308888 -87.266369648635532,40.452521074128647 -87.266724742485749,40.452520255353576 -87.266902322023341,40.452528089691441 -87.267079923771846,40.452556417561759 -87.267246836737556,40.45258071668497 -87.267440643256649,40.452621350778465 -87.267629102874309,40.452666139300739 -87.267871609723244,40.452764182888629 -87.268124980028674,40.45289512715425 -87.268400021246777,40.453063003719514 -87.26848454932049,40.453115426759737 -87.268842306300428,40.453337294328172 -87.270071935095245,40.454098848391247 -87.270266054869509,40.454201142334924 -87.270513970163805,40.454307411005978 -87.270670169388538,40.454364612476517 -87.270820981494822,40.454401241515576 -87.270998681883881,40.454437808226452 -87.271327019157638,40.454482218550325 -87.271542284771613,40.454489955488796 -87.274087080800626,40.454508589485869 -87.275684880876483,40.454492492589068 -87.277115986607484,40.454493169855205 -87.278708470101691,40.45448934130021 -87.280403195516996,40.454497540233405 -87.282431483649987,40.454500846645473 -87.282592684843209,40.454502674318476 -87.283921804169609,40.454517735624044 -87.286418179898305,40.454519821451278 -87.288215150192201,40.454539994905296 -87.290302750010255,40.454567654225315 -87.29389144232762,40.454620208192644 -87.2950160071222,40.454642028517419 -87.297006746054564,40.454673912145594 -87.299680728833138,40.454699893996754 -87.303898823056699,40.454729964066317 -87.306126171579791,40.454740527672591 -87.308445037434836,40.454750806004199 -87.310220479793685,40.454754297390927 -87.312286357111574,40.454748734859962 -87.312539271218,40.454748051332921 -87.312738401804197,40.454772153483212 -87.312964557111073,40.454812621880428 -87.31326611029904,40.454873473061113 -87.313492400033553,40.454942724942661 -87.313702609449223,40.455028460672573 -87.313832074519169,40.455097974605472 -87.313988524957608,40.455187956678309 -87.314128799415613,40.455273882468319 -87.314290769986812,40.455396731332861 -87.314669298886287,40.455802551136728 -87.316334607636634,40.457565223784869 -87.317686686614053,40.459053327809031 -87.319006217573033,40.460467585149992 -87.319773990252571,40.461262765640328 -87.319909151892901,40.461397977105968 -87.32004419736019,40.461508594899151 -87.320243858484844,40.461627232680407 -87.320443441967711,40.461729382849221 -87.32068599878356,40.461827358481194 -87.320955585694449,40.461941701887241 -87.321133469513143,40.462006928919998 -87.321266948767231,40.462029504990348 -87.321348842453432,40.462043356710289 -87.321574831335269,40.462042728235481 -87.323215983156942,40.462054593372173 -87.324631146287842,40.462067023251329 -87.327192434173384,40.462092684769424 -87.329312497952301,40.462111349141992 -87.333154452762727,40.46214142207883 -87.334316658471749,40.462150408084142 -87.334795508219727,40.462144923036824 -87.334994502668337,40.462123760812645 -87.33526331800951,40.462077801934541 -87.335472943201182,40.462036066502598 -87.335693176515264,40.461957364552546 -87.335918755291033,40.461874501581107 -87.336364115711419,40.461634870969803 -87.338092133464556,40.460729780655498 -87.339337289865455,40.460105543041145 -87.340276333195206,40.459605527521489 -87.341424784054468,40.459014434148564 -87.341666257711296,40.458894531694824 -87.341870190242247,40.458791179503557 -87.342058231626069,40.458729001240719 -87.342305340632507,40.458662504504595 -87.34257946157507,40.458608267801374 -87.342912893355376,40.458574396977482 -87.343192588835691,40.458561223601741 -87.344295581570748,40.45855794361826 -87.344725284645392,40.458562327853386 -87.345231808514256,40.458567494604203 -87.347260236624578,40.458573760248854 -87.349331675907308,40.458583960346694 -87.350612213415488,40.458588281646982 -87.352075716388441,40.458587932509005 -87.353770567891317,40.458599200353738 -87.355739768238536,40.458601399321083 -87.359269104054988,40.458565799124599 -87.360436455486422,40.458533426179436 -87.36206643897782,40.458479008508839 -87.363239197844436,40.458454788567025 -87.363873988079789,40.458436349648622 -87.364121354914388,40.458410885889364 -87.364368485184087,40.458352584329958 -87.364631765213545,40.458281889791543 -87.364867917262615,40.458178395420234 -87.365055690684031,40.458070956039172 -87.365254137124921,40.457963481726907 -87.365420251458133,40.457831423564542 -87.365596949850669,40.457682936100674 -87.365821674862786,40.457452088719357 -87.365965973015633,40.457266676882483 -87.366932361295184,40.455907388464404 -87.367060674973686,40.455754953176687 -87.367199764679157,40.455610637614726 -87.367360444601218,40.455478638930046 -87.36756419263088,40.455350558962692 -87.367767985070472,40.455230765929514 -87.368041712331163,40.455110704848877 -87.368229704821474,40.455056682414181 -87.368476810746714,40.454986028817416 -87.368654205091886,40.454956679260789 -87.368885377753145,40.454927158730655 -87.369218911503467,40.454917895645835 -87.370526224399399,40.454913712648242 -87.373006491859698,40.454922176560935 -87.3733239143655,40.454921151865207 -87.373555130440721,40.454899865149997 -87.374263333241288,40.454844870475583 -87.374576253600978,40.454808361213829</coordinates></LineString><LineString><coordinates>-87.37787165115563,40.462365693880791 -87.378013438381814,40.46231504988139 -87.378111647796914,40.462296845706689 -87.378397159706452,40.462288749221649 -87.379253735270069,40.462271617599221 -87.380887371394209,40.462255524457994 -87.386200226851699,40.462209293072881 -87.387028709800816,40.462199404030372 -87.389612483340954,40.462162121224239 -87.392215110955021,40.462142553706023 -87.394775528968381,40.46211599964996 -87.396446667179035,40.462110280193741 -87.396867864460219,40.462103623103921 -87.398183197812386,40.462082824759108 -87.40040663829096,40.462068026145353 -87.403402370038691,40.462036123599304 -87.405003241380598,40.462016247203337 -87.407254770883412,40.462004732871172 -87.410175751371852,40.461998008313444 -87.412094983786176,40.461991181994328 -87.413518015103165,40.461986099987904 -87.415264064422146,40.461983399038694 -87.415919182905185,40.461982581502618 -87.416799460507718,40.461981476524215 -87.420815920445122,40.461988364816072 -87.422468318815177,40.461985896843245 -87.425642112508683,40.46197785626876 -87.429447849369467,40.461974501408555 -87.431956938378846,40.461975873101352 -87.434451968434288,40.461973684598576 -87.435080101020318,40.461974931965806 -87.438182874449424,40.461981043218032 -87.440167691022822,40.461984222895957 -87.442175895345443,40.461983720456587 -87.446889897371321,40.461997753920741 -87.448659318443532,40.461998061756148 -87.451454001031095,40.462005062629594 -87.454179572620319,40.462010649479019 -87.455643683070704,40.462013624395411 -87.459079566494111,40.462007191737456 -87.461509096566019,40.462008236965957 -87.46440669568517,40.46200735242644 -87.466269847374704,40.46201057352436 -87.469186140159991,40.462009538805781 -87.473090295237554,40.462022228587195 -87.473247507996845,40.46202243909589 -87.474401020754712,40.462023974652034 -87.47730338695024,40.462029909418305 -87.481736446423909,40.46203656339268 -87.484320448941418,40.462040045620107 -87.487686091803297,40.462025894706706 -87.49047611137911,40.462031971741474 -87.491521518388112,40.462035059969601 -87.491964725223042,40.462036366386975 -87.493444066020785,40.462055106701612 -87.49511541643615,40.462080122025704 -87.497062938239338,40.462103970059971 -87.497891533590519,40.462103962524751 -87.499178820240729,40.462102014140839 -87.50053165160088,40.462103282037127 -87.502923515848565,40.462075016182148 -87.50784314878338,40.462046390380181 -87.509724855594371,40.462030945663038 -87.510566430313261,40.462025511641279 -87.511466174584513,40.462019694297105 -87.513844097840845,40.462012707427952 -87.516540468172892,40.462011410298757 -87.51839412298996,40.462006669638193 -87.520973348456366,40.461995073667403 -87.525106615461013,40.461976370845065 -87.526785973790254,40.461990982789885 -87.526810948851818,40.461964472536387</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-87.374215771062723,40.454781824984316 -87.374263333241288,40.454844870475583 -87.375067523006848,40.455911730501512 -87.375664799567758,40.456680065586575 -87.376092085365045,40.457291292153961 -87.376412715811895,40.457789125077909 -87.376619604180149,40.458172462237691 -87.376637997730626,40.458213708831103 -87.376859794906665,40.458710691232817 -87.377055643464246,40.459206946091321 -87.377269139444664,40.459873955535869 -87.377394703810751,40.460434449303484 -87.377490754737238,40.460937157006455 -87.37750554904315,40.46109373105697 -87.377558895678845,40.461658108116801 -87.377560232395965,40.462254999279892 -87.377560664071183,40.462378066881371</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-84.804071516974275,40.416692633984326 -84.804171639044171,40.416776222644778 -84.80495227935981,40.417427942463242 -84.806149330634895,40.41844813759851 -84.807652541228734,40.419692216497126 -84.80886764914321,40.420734120438958 -84.811795626087104,40.423195659924453 -84.812997882573811,40.424205163594237 -84.815915755918752,40.426698522074403 -84.817431499292951,40.427999911122363 -84.818974475547591,40.429330351852336 -84.819953579713612,40.43015680632341 -84.820809650414674,40.430884411737956 -84.821980119113363,40.43187174071064 -84.822216939153478,40.432072849616929 -84.822409123263085,40.432205151830722 -84.822643370122321,40.432341849531156 -84.8228594021314,40.432460323440949 -84.823090204927595,40.432557634172689 -84.823362376586374,40.432677164724645 -84.823424385442053,40.432698101858136 -84.823653972740658,40.432775620338163 -84.823876563071138,40.432837013648715 -84.824075770102908,40.43289796622598 -84.824340307435762,40.43296370579565 -84.824623923112611,40.433019086101758 -84.824842784188291,40.433051805787905 -84.825052624519614,40.433073637457731 -84.825286021788187,40.433088749753566 -84.825519595046757,40.433100306696595 -84.825715875718217,40.433107603287837 -84.8264921538089,40.4331186037886 -84.82817135104078,40.433132294786709 -84.830304080870562,40.433154476934639 -84.832048843912219,40.433165785290448 -84.835004632244249,40.43319976088479 -84.83610378138718,40.433209629937075 -84.837838727139072,40.43323494387861 -84.840060818930269,40.433244340857115 -84.843522270073834,40.433266064610066 -84.844468982092849,40.433271625544158 -84.844920907029987,40.43327427681821 -84.847156685474005,40.433294511194674 -84.852175900593224,40.433323547965628 -84.853508981299058,40.43333404087403 -84.855080528867504,40.433348899004173 -84.856834571114959,40.433363561388774 -84.860824693560261,40.433387454531179 -84.862415259266186,40.433391890252359 -84.863590528190343,40.433401110321938 -84.864094494621028,40.433405060328631 -84.866728717731391,40.433400076471862 -84.869409490990932,40.433403051327154 -84.870438560783072,40.43341130136838 -84.872033734072787,40.433419246774584 -84.873385506639707,40.433429808417223 -84.875369227203308,40.43343058052448 -84.878110805396844,40.433434472134657 -84.879233819555338,40.433430045813424 -84.881026190373575,40.433416444104424 -84.882441003344852,40.433407623391545 -84.882771674371881,40.433405558777224 -84.884437968092598,40.433382432595145 -84.886792461532082,40.433346871817598 -84.888580234791803,40.433329464549317 -84.891566677391481,40.433283912718998 -84.894062216922265,40.433225734320281 -84.895452410524243,40.433204578613243 -84.896936374806813,40.433177996286034 -84.899080551923916,40.433134753767746 -84.901032642275553,40.433098702299908 -84.901754423587008,40.433085461254947 -84.902011071661164,40.433080752506974 -84.904126147977408,40.433069047015536 -84.905787451457613,40.433056286775312 -84.907968258128221,40.433038585593202 -84.909344680324025,40.433035144837106 -84.909877288373835,40.433033809140362 -84.910616039238491,40.433025429971188 -84.912793123293298,40.433000707891715 -84.914220502947842,40.432987159205709 -84.916873929051135,40.432967099482582 -84.919962566662974,40.432944047505423 -84.920754263019816,40.432943495415387 -84.921492475569423,40.432942974940374 -84.922966578885436,40.432933761730574 -84.925502853221886,40.432918514400008 -84.927632126231245,40.432903118906609 -84.930061049541209,40.43287868472062 -84.93109994614565,40.432872291104339 -84.933201011222792,40.432859846993594 -84.934904553463639,40.432843819783443 -84.938750898240897,40.432826687262533 -84.941142256428691,40.432808511334223 -84.944356984440859,40.432790657992015 -84.947375034997634,40.432779984875935 -84.948526488686127,40.432764669701669 -84.95078656316123,40.432754727216171 -84.952569364174011,40.432747007130047 -84.956135294367215,40.432720723547369 -84.957801373833789,40.432703695803923 -84.959453815324494,40.432675683429323 -84.960867396934887,40.432654152675319 -84.964860468517116,40.432581536860255 -84.965515804420534,40.432571635425447 -84.965905819465718,40.432561742980099 -84.966929814929273,40.432535760838498 -84.967675017087672,40.432525835443805 -84.968323157248363,40.432517198603101 -84.969359019366408,40.432503387158384 -84.970483015854469,40.432465929980324 -84.970729951910116,40.432462980540024 -84.971927321819209,40.4324486723497 -84.972542349370499,40.432441317922908 -84.973054001690684,40.432442651586484 -84.973501399169194,40.432443816518216 -84.974195237958128,40.432433062717379 -84.974475005601818,40.432428726005526 -84.976012250990877,40.432400184257808 -84.97625856113325,40.432395609463036 -84.977776502390881,40.432372816438473</coordinates></LineString><LineString><coordinates>-84.978093960815343,40.439525312799084 -84.978913816842251,40.439498216853082 -84.979720363450355,40.439486370226547 -84.980247899731609,40.439478617539294 -84.98136909802227,40.439462046734612 -84.981577385479042,40.439458967548141 -84.982677571036291,40.439438857826744 -84.982782597551974,40.439437325753474 -84.984685793639358,40.439409534117843 -84.986525684962643,40.439377243540861 -84.987996035720343,40.439338533421967 -84.989620280508348,40.439320319126161 -84.991871234963554,40.439309371830774 -84.992106120986207,40.43930462342086 -84.993392866369533,40.439278600555326 -84.995153214872403,40.439244836241755 -84.997245948537383,40.439206039406983 -84.999249984725125,40.439158509250674 -85.003715913494645,40.439089178466034 -85.004886583434939,40.439059354775829 -85.007288144287429,40.439018547436362 -85.012400523492971,40.438924264184386 -85.012770112644716,40.438927016146344 -85.013079152370878,40.43891805290415 -85.013370310628176,40.43888373760204 -85.013562875802947,40.438858445760758 -85.013760469803643,40.438822521116236 -85.014024364369121,40.438759135265229 -85.014292914427088,40.438695782860954 -85.014519499084841,40.438628195605155 -85.014717933196977,40.438563681652603 -85.015064567297529,40.438390868273757 -85.015183518640782,40.438324988256632 -85.015551663041364,40.438535078215459 -85.015846977581816,40.438676037597553 -85.016013313356581,40.438746816515774 -85.016166526228417,40.438788767819844 -85.016366251896628,40.438838678890015 -85.016510878563324,40.438851881158129 -85.016702556675881,40.438858728303074 -85.016950323572516,40.438866584475917 -85.017915291830946,40.438829495257735 -85.019239953470446,40.438812885990338 -85.019747495288797,40.438807362047555 -85.021154347817998,40.438792039200102 -85.022998824106139,40.438759245615032 -85.025095782681049,40.438734339135678 -85.02981831471736,40.438689824657146 -85.031465574783653,40.438682132755112 -85.033187978289291,40.438664977337041 -85.035289337974262,40.438650681306399 -85.037643276230156,40.438637032995977 -85.038495325440437,40.438622897136788 -85.038752198367234,40.438638021766351 -85.038757326954908,40.439106448782098 -85.038763848961608,40.440490139521216 -85.038768973686388,40.441923848074047 -85.038786585243486,40.443250523044902 -85.03880199009447,40.445295795302705 -85.03879355441893,40.445890499148327 -85.038793117106337,40.445921313490423 -85.038846414255374,40.445921101892353 -85.039134803457429,40.445919951281361 -85.040418364881745,40.44587380214108 -85.042999039216568,40.445795967708314 -85.045115895381542,40.445738832297963 -85.047574892590404,40.4456624421627 -85.048337258354877,40.445642231037304 -85.051775667339172,40.445551012605101 -85.054023449496242,40.44549592098933 -85.055835880313737,40.44544778433221 -85.05777681063681,40.44539527500946 -85.058280471930743,40.445381643514018 -85.060429562525243,40.445342649300386 -85.062058672761879,40.445319895921074 -85.06400151899733,40.445291699445754 -85.066197439644213,40.445249824996772 -85.069095145245299,40.445212476407796 -85.072611103290257,40.44515676521921 -85.074544681965463,40.445124635175191 -85.076730033766196,40.445088763891796 -85.07692297510448,40.445085594274069 -85.077765943644366,40.44506385636388 -85.07900683860916,40.445034449664433 -85.080767243924527,40.445002893905645 -85.082958603107457,40.444957066492186 -85.085744554414561,40.444899563553797 -85.086097485200199,40.444892740900251 -85.086442195521414,40.444886075617688 -85.088179304572577,40.444850506893331 -85.089860417387612,40.444810338996106 -85.091789736521562,40.444763570545142 -85.094781556138855,40.444705691283254 -85.095516584351643,40.444690612785742 -85.096425044328385,40.444671969050354 -85.099252512906645,40.444636308721876 -85.103296871668249,40.444591911752731 -85.10499211965417,40.444575444602378 -85.105623207888513,40.444569308157398 -85.107397328363874,40.444548335969401 -85.109381637851527,40.444541451195107 -85.111998218523283,40.444516305593083 -85.113922115206023,40.444494122609385 -85.116332960978724,40.444461918367089 -85.120653835912108,40.44440358364303 -85.122591459993018,40.444392152478876 -85.123915551447354,40.444377813406 -85.124571514770338,40.44437070431772 -85.129313907280064,40.444297400414925 -85.131088126957422,40.444272462377697 -85.133873953782285,40.444217398076127 -85.137979618217841,40.444154895206246 -85.140123768726454,40.444121499063513 -85.141649877527769,40.444099566972355 -85.143564657689041,40.444069581686357 -85.146617461552964,40.444004175860613 -85.149984292985593,40.443922276938459 -85.150412243839369,40.44390286674345 -85.150472923419699,40.44390874744726</coordinates></LineString><LineString><coordinates>-85.150549681259477,40.451178364637606 -85.151837321907692,40.451154734205616 -85.153748078927066,40.451106635349724 -85.156060929279207,40.451072036363449 -85.159010818522049,40.451018985860912 -85.161333623221907,40.450963000815882 -85.164644051229075,40.450901219864882 -85.167659315852745,40.450852544905551 -85.172154243897538,40.450773559892085 -85.176297745885037,40.450710339378901 -85.178554385455698,40.450677961784216 -85.182051631710252,40.45062938918938 -85.184995928246252,40.450607701443694 -85.187149124588629,40.450591457780263 -85.188195281000915,40.450585629911693 -85.189503527269181,40.45057832731176 -85.193678261969907,40.450572130422991 -85.195639110855879,40.45057416168018 -85.197674809579723,40.450577326130663 -85.202340916089497,40.450571362768414 -85.203707505085532,40.450571172103558 -85.205752295026372,40.450585057250031 -85.206442741820425,40.45059311771994</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-85.206442741820425,40.45059311771994 -85.206623147046614,40.450598687587423 -85.206744844077875,40.45060244443782 -85.207970598676368,40.450583713532865 -85.20980078541541,40.450572758064091 -85.213082105734856,40.450548458737757 -85.215061896591294,40.450543336419486 -85.216690782331966,40.450532720663695 -85.218614468432634,40.450526625694913 -85.218853232203443,40.450523144267486 -85.219063941007946,40.450519275939584 -85.219312205735122,40.450508778300872 -85.219640469150107,40.450485233390239 -85.219926501259366,40.450464597165926 -85.220116691318239,40.450448765691348 -85.220325123622487,40.450431414955837 -85.220498878025097,40.450409091420923 -85.220700595697508,40.450390713249512 -85.220944260443389,40.450380185413749 -85.221286304257006,40.450364011443227 -85.221548747827242,40.450350168905615 -85.22192818003613,40.45033812492872 -85.222377652672307,40.450330716323066 -85.223739906320944,40.450315944434095 -85.224896637126676,40.450287234694137 -85.226961340845278,40.450254566729619 -85.22911054557602,40.450212434941157 -85.232440061090387,40.450134723846823 -85.233938454077077,40.450103987041828 -85.235170028853275,40.450076318089849 -85.236237540459371,40.450056852167108 -85.237337724085563,40.450041477177599 -85.238660197644023,40.450030611339713 -85.239013553037424,40.450027704110362 -85.241105187086475,40.450038118647512 -85.244077140608297,40.450033226809921 -85.245612211493352,40.450031541656728 -85.249791450339984,40.450030546791702 -85.251967498611023,40.450034879491035 -85.253535157883348,40.450040699500043 -85.25537410599793,40.450050594955464 -85.256961004565028,40.450035218835318 -85.257505347712652,40.450030098862698 -85.257691286142745,40.450028349435911 -85.258281455932007,40.450008643798689 -85.259204072422619,40.449983222434128 -85.260740163699211,40.449941986478876 -85.262646308807831,40.449888456272291 -85.264889555464862,40.449829191259923 -85.266289600749545,40.449800161278226 -85.266973174928751,40.449788973213167 -85.268190934390006,40.449750024751239 -85.270317093537415,40.449692457912164 -85.272864846614354,40.449619759243134 -85.275590593268078,40.449542452723925 -85.276157085975981,40.449533021528879 -85.276631880060492,40.449530028668306 -85.27670691619457,40.449529555818643 -85.276831105052253,40.449528796073736 -85.277719999198823,40.449542046649178 -85.279216920235868,40.449567902943535 -85.28133151346168,40.449595812450319 -85.284302148446187,40.449639952634392 -85.285410611855426,40.449667122701129 -85.286986926366794,40.449701218816088 -85.2890966965887,40.449736031364431 -85.292965385393146,40.449800402213832 -85.294658642676609,40.44983612094952 -85.295295778184055,40.449848309991985 -85.295481919972943,40.449851869949406 -85.297082039587735,40.449868297623276 -85.301611653491932,40.449892028907158 -85.303235415035289,40.449901601185985 -85.305285012273799,40.449910236084847 -85.307634289854093,40.449912457491457 -85.310174876820639,40.449938912896819 -85.311877975282087,40.449956641301398 -85.3136289390862,40.449967101188221 -85.313950890423286,40.449969021369931 -85.316206192870453,40.449987623310136 -85.318812630727621,40.45000052645856 -85.320881014790146,40.450005597731895 -85.322925795133841,40.450020965387935 -85.326669239537367,40.450043067825213 -85.326954713356898,40.450043597509733 -85.327141934128946,40.450042749349848 -85.32731056045327,40.450038028364496 -85.327441967035568,40.450022049279326 -85.328202171138443,40.44994012630297 -85.329638616593243,40.449764241597286 -85.330230280587458,40.449683427478782 -85.330812188460101,40.449620305316103 -85.331154831537916,40.449578769901272 -85.331370460445726,40.449564001600919 -85.33153686316524,40.44955372553197 -85.331585639943924,40.449550712810129 -85.33174543093817,40.44954081303414 -85.332171413008453,40.449536241285593 -85.332695263620366,40.449550961806871 -85.336075373450086,40.449692644784278 -85.337917675165912,40.449758478032287 -85.340120160097314,40.44982945478263 -85.342191425999744,40.449909227428421 -85.342357698370591,40.449912961024026 -85.342635801985466,40.449919204455512 -85.344716971430415,40.449977632736079 -85.345227414214435,40.449995902387009 -85.34588124634503,40.450019301288755 -85.347349827811854,40.450058194327511 -85.348696584020914,40.450102488922646 -85.34996892583969,40.450127823520589 -85.351596856496343,40.450158170611338 -85.353383809186965,40.450190806548505 -85.355996491277793,40.450233903757251 -85.356541541633561,40.450242916267506 -85.358005830958433,40.450267289297926 -85.35977850452069,40.450310342669574 -85.360596988048442,40.450332676276354 -85.360583440542342,40.451252705916367 -85.36058267078117,40.451304942538812 -85.360640910442143,40.451305543480636 -85.360682241580676,40.45130558835141 -85.361963279452823,40.451306636371683 -85.363254657353608,40.45132137443089 -85.365170851443381,40.451318005623591 -85.36572585357888,40.45131702428403 -85.366257528972511,40.451319607602066 -85.367400349038178,40.451325151761303 -85.367456127576659,40.451325174889412 -85.368000107006168,40.451327723104441 -85.368551070522585,40.451332002395027 -85.370170204382163,40.451344563747135 -85.370221186753099,40.451345328667287 -85.371218437441186,40.451340254643178 -85.371463136967506,40.451339008744633 -85.372464754724959,40.451335235878155 -85.37393416654507,40.451341642385145 -85.374108325481259,40.451341413553017 -85.375155070629177,40.451340030504873 -85.375210146989517,40.451337336559611 -85.376807966334312,40.451331998941967 -85.377378932879409,40.451332855103402 -85.37752433361382,40.451320572930968 -85.377641445694394,40.451315099377602 -85.377867390065433,40.451261067761763 -85.378079478103331,40.451199678565509 -85.378817113478917,40.45088468559419 -85.379128916143273,40.450763929809298 -85.379445631437406,40.450632478678884 -85.379535459588453,40.450594416044389 -85.379606327044925,40.450576912495059 -85.379686115155366,40.450557206169862 -85.379785229322081,40.450522830996576 -85.379968054627241,40.450511116340742 -85.380709031184338,40.450518809070935 -85.380959947713833,40.450521412821473 -85.381859395273111,40.450524066254637 -85.382251578839316,40.450525220911601 -85.384422478905279,40.450552030450766 -85.387412482543894,40.450575908674402 -85.389031673588164,40.450595832941985 -85.389602075090153,40.450602836652116 -85.391955553800855,40.450628489331066 -85.396124440890048,40.450672096510822 -85.398637014531118,40.450699776722345 -85.400980965594513,40.450732231150795 -85.403368355358268,40.450763031953528 -85.404803396252234,40.450781496270409 -85.406599959137097,40.450806279902892 -85.407892724649074,40.450814538289052 -85.408537263072262,40.450818650171961 -85.41130781273138,40.450821050772035 -85.413456108767235,40.450814797511015 -85.41504272520676,40.450811524662775 -85.417027112024499,40.450810118778101 -85.4173658589811,40.450809190809316 -85.418983526458916,40.450804739563473 -85.422077165679795,40.450800535135869 -85.423111559050014,40.450796770471143 -85.425002431449215,40.450790394102974 -85.427061597521501,40.450793394153315 -85.430716259343924,40.45081447452759 -85.431527995115061,40.450823984875193 -85.432629930414919,40.45083688502951 -85.434735736163148,40.450847543491399 -85.436434401393285,40.450856213568017 -85.439397024721472,40.450849816791767 -85.441549969022375,40.450846663022318 -85.443089546463867,40.450853135810462 -85.444301779165059,40.45085157696932 -85.444755749127268,40.450850525095831 -85.445055430408459,40.450843838204953 -85.445292363042526,40.450842790807151</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-86.69460266684753,40.417661445983327 -86.691530895989402,40.417613830583477 -86.68145429792628,40.417550606295769 -86.67551756127979,40.417523873128978 -86.671579259590658,40.417503744299367 -86.669174748500481,40.417487880136633 -86.666246461314927,40.417474959769038 -86.66504885062011,40.41742194631059 -86.664104380895623,40.417284069439354 -86.662833307531784,40.417037123372189 -86.661833017825344,40.416867533212177 -86.66119748021751,40.416816122451628 -86.660505112791313,40.416791568724094 -86.659774977743922,40.416811945355022 -86.658979705208324,40.416881675466449 -86.658155593121293,40.416978342219494 -86.657294598801329,40.417083902904807 -86.656573732358311,40.417158341539327 -86.655862571280068,40.417201272625796 -86.655142130161792,40.417203630594337 -86.654336972845911,40.417187712583889 -86.653607908764243,40.417135980462334 -86.652746995096138,40.417074838699314 -86.651307576600914,40.416921856050052 -86.650446751290289,40.416856192866099 -86.649857406385905,40.416854409611553 -86.649352029828293,40.416843868913105 -86.648688053261111,40.416891403521262 -86.647071410464818,40.417057653430824 -86.646613122958954,40.417114812918463 -86.645888673700171,40.417162146595537 -86.645355125194015,40.417196547757577 -86.644737546709734,40.41723969741485 -86.644016973961129,40.417255499339127 -86.643371542791115,40.417271528569017 -86.640106723125157,40.417229880277979 -86.637524819283939,40.417194787349345 -86.632777219661307,40.417157598443396 -86.626306597765208,40.417150064338536 -86.618485276304526,40.417124520693115 -86.61550105236239,40.417096616829639 -86.605349808764117,40.417026376415329 -86.604217563519796,40.41702250614069 -86.602973493823825,40.416982204371713 -86.601969660945031,40.41697965297692 -86.599615061327697,40.416961614003185 -86.599007331455297,40.416959507877678 -86.597912654943215,40.416951201591097 -86.594886337083054,40.416958204359197 -86.594805948120566,40.416958374018385 -86.592177347223952,40.416971654916551 -86.591129139298047,40.416958943742941 -86.584018596521645,40.416956102642025 -86.580678198515415,40.416993586316167 -86.574877694861897,40.416958890309303 -86.573001295759113,40.416960984871672 -86.569198635407957,40.416937869526407 -86.56822551738874,40.416934239578936 -86.563417242853461,40.416911678867848 -86.553799234952436,40.416874961024078 -86.544181244938969,40.416837443136991 -86.534741733488261,40.416772816167949 -86.52530361748417,40.416738910156731 -86.525246039168479,40.416738719690883 -86.522981585039872,40.416720390169338 -86.517966994765686,40.416708601523318 -86.515721693888096,40.416699218761515 -86.514879138111752,40.416685505416822 -86.51403715288815,40.416682646097797 -86.513373265556922,40.41668034929134 -86.512634392294757,40.416672732561679 -86.511015933805126,40.41667040356468 -86.506310278440409,40.416627883635662 -86.499994757481645,40.416609753239598 -86.496032777995808,40.416619578736537 -86.492072475332023,40.416602248536364 -86.487213379594394,40.416589808998431 -86.478151037183622,40.416540252025861 -86.468529620923292,40.416487416146893 -86.464736991465813,40.416501452025877 -86.459064840302645,40.416556135203379 -86.453688307565216,40.416580405479174 -86.449558015647142,40.41663288829011 -86.440990893118382,40.416744938588508 -86.436860924479603,40.416756428436649 -86.430765598596324,40.416843697490563 -86.423825877174593,40.41684986308173 -86.417469672939077,40.41686305809867 -86.41618248199724,40.416793502013086 -86.415641784159178,40.416619598020866 -86.415051608058633,40.416463459338814 -86.414207869563597,40.416324051377906 -86.411854965542631,40.416059852071598 -86.408458583173285,40.415668648318032 -86.407844322890298,40.415660999401531 -86.406872108425375,40.415719079528522 -86.403585658642029,40.415904877400479 -86.402444715087569,40.415962049771579 -86.401461651836627,40.416006514696484 -86.400754312518487,40.416020868896261 -86.398251148430418,40.415926786336961 -86.395432283967835,40.415799467473569 -86.39294169067378,40.415698623953539 -86.392876945860081,40.415695986677456 -86.391853299170549,40.415659075133846 -86.391314159722143,40.415647228962477 -86.390754653665425,40.415684822852519 -86.39017258041541,40.415780853969196 -86.389505672196833,40.415971029475983 -86.388785377549027,40.416192450653277 -86.388351291779486,40.416293759352762 -86.387854261246062,40.416349687821551 -86.386872239070698,40.416348988816758 -86.384294660286969,40.416344300128529 -86.383428446115246,40.416330674927075 -86.382952537871091,40.416409217623432 -86.382293589197715,40.416531825920487 -86.381005153916206,40.416853766033931 -86.380073308338964,40.417087513621489 -86.379543980642936,40.417206296614054 -86.379079349435131,40.41726236118442 -86.378519283703326,40.417281874669492 -86.375624700962177,40.417297810831407 -86.372349693412687,40.417338637122818 -86.369202027827356,40.417393579060338 -86.366275862245786,40.417395595215901 -86.361458716704348,40.417463686087856 -86.359293271115916,40.417492247026999 -86.356810330614877,40.417528010634605 -86.347220891177514,40.417433725007584 -86.342478145134123,40.417424867997831 -86.337735904743127,40.417370774041899 -86.332961330780805,40.417374857870222 -86.328060821294798,40.417378012658254 -86.320530840429853,40.417329500195862 -86.318734122250078,40.417319242365188 -86.315840497511289,40.417315353807858 -86.309234006876252,40.417294089219347</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-85.862204413500606,40.421407438470098 -85.857107591007093,40.421442835519009 -85.852146270237213,40.421467372392755 -85.843507551319433,40.421514695756926 -85.843403752020592,40.421515277997024 -85.836498439461749,40.421552470419563 -85.831623659704206,40.421588888813993 -85.825699641226066,40.421636970183911 -85.825552774673753,40.421636604315658 -85.824560484139383,40.421634041424596 -85.824512098529269,40.421633909786969 -85.824223388467658,40.421632415138646 -85.813651579423308,40.421577019073879 -85.805577391575838,40.421555002128628 -85.805232655904348,40.421555538762824 -85.798994700476925,40.421565313076684 -85.791899616029738,40.421594984967385 -85.786570193559399,40.421633759408166 -85.786052094357871,40.421635842306358 -85.779417602156215,40.42166206123256 -85.770747091666138,40.421705320224078 -85.767098328200092,40.421734029311715 -85.766491977273702,40.421743730810626 -85.761692163046547,40.421820386225477 -85.748015756960825,40.421974871047837 -85.74750369312008,40.42198189048807 -85.74086183079568,40.422072842057261 -85.735638934535004,40.42211385088028 -85.735580990236912,40.422114298161084 -85.734781260461986,40.422123834977413 -85.728885562564429,40.422194019711633 -85.728135522404813,40.422212660283904 -85.720468985853913,40.422402960115832 -85.715607488031054,40.422470666004543 -85.711424637010921,40.422496185886885 -85.709810068538587,40.422518716578587 -85.709149926299645,40.42252364387231 -85.704739130352252,40.422556601071555 -85.700383663529436,40.422593300133606 -85.696010969167745,40.422566579301872 -85.690919459311303,40.422531328972191 -85.690864890261651,40.422530937117649 -85.686127392467938,40.422585293601841 -85.678974560114597,40.422620887919877 -85.672950587906087,40.422574412223163 -85.672043748473513,40.422572375479675 -85.671976619628055,40.422572235814606 -85.671929704334701,40.422572327439553 -85.669245518470547,40.422576862764963 -85.667420646028589,40.422614397371333 -85.666207293405293,40.4226499518902 -85.664497321644092,40.422688766007049 -85.661785190895245,40.422702444508822 -85.659942675157623,40.422699117372112 -85.656549802272224,40.422668698569872 -85.656524876326102,40.42266845482655 -85.655235635925948,40.422666977132131 -85.654118132416272,40.422662980320851 -85.653891103731482,40.422662948464854 -85.652943735258162,40.4226628141028 -85.652751672408215,40.422662061368307 -85.65177520439822,40.422658245041042 -85.65161227262287,40.422659541829965 -85.65063333303749,40.422667398385492 -85.650472871424483,40.422666065724343 -85.649248462781841,40.422655728817169 -85.649143599019766,40.422656439412542 -85.648035706255854,40.422664073216367 -85.64781436138432,40.422668645308256 -85.647338416348489,40.422678437793351 -85.647244845881943,40.422677342835911 -85.646221802909409,40.422665366290005 -85.646105518723701,40.422665399856058 -85.645094667475021,40.42266567377542 -85.644966094994317,40.422664166710057 -85.644502419812753,40.422658730542331 -85.644053257543263,40.422684993328133 -85.643489536893398,40.422727927567969 -85.642885763005779,40.422784261383889 -85.64224579036005,40.422843952338482 -85.641202806356532,40.422944306302149 -85.639978565844672,40.423042518446344 -85.639867634985734,40.423051798523453 -85.63775950856602,40.423228094537642 -85.637602443311948,40.423242413270408 -85.636535046182843,40.423339780626684 -85.635989973689391,40.423369385085607 -85.635416204534096,40.423398648216811 -85.634595042899193,40.423420482225872 -85.631701576318392,40.423399781811753 -85.628666019338013,40.423372819024365 -85.62116119120634,40.423324083391726 -85.621091771500431,40.423323659814962 -85.616666972718164,40.423297414519837 -85.61405620600317,40.4233246985779 -85.611061792626103,40.423338305832928 -85.606747106226877,40.423394486560952 -85.60665990676587,40.423395912919226 -85.604519956843333,40.423430682510038 -85.604381577960822,40.423433110858916 -85.601159250518648,40.423489158462345 -85.597012727456331,40.42356953221158 -85.591742570839173,40.423478421309781 -85.58787386902226,40.42344924255648 -85.587673466343972,40.423449812133903 -85.580397851118988,40.423470280736765 -85.57839546142641,40.423468193929061 -85.5783681277277,40.42346754156388 -85.576198138005708,40.423414123716718 -85.573626393241796,40.423337374773119 -85.569035646960842,40.423172531712815 -85.566342844948551,40.423107635091803 -85.56622389693834,40.423102601341576 -85.563940278889689,40.423005742705008 -85.561518823429594,40.422930591380002 -85.55894721832027,40.422849013239542 -85.558825406078896,40.422848440511331 -85.557216799813503,40.422840940995449 -85.553407607856968,40.422892429246097 -85.553318844261426,40.422892579597381 -85.550858458760402,40.422896534579415 -85.550660485608844,40.422904817882262 -85.54961524509406,40.422948465036349 -85.549333175250283,40.422936409574532 -85.549317865215187,40.42293576700267 -85.54806619052259,40.422933564879187 -85.547814015987456,40.42293535188567 -85.544611206116585,40.422957681240391 -85.540418447387367,40.422994902499568 -85.540218340284071,40.422992780083256 -85.533908017578895,40.422926025552563 -85.522720305722459,40.422819622149269 -85.522558974662857,40.422817785432052 -85.51988458945948,40.422786897935254 -85.515480186757046,40.422735874808915 -85.508520878602098,40.422646288795384 -85.500758997788211,40.422473807801282 -85.498456129054759,40.422466437995553 -85.494031191769992,40.422444907703216 -85.492861126332784,40.422452179368953 -85.492864711109107,40.422537132548698 -85.493008333243807,40.425922424434717 -85.493255340679127,40.433704596896426 -85.493307904505016,40.435543041287268 -85.493309409305937,40.435594455092215 -85.493576800749523,40.444456067230547 -85.493580231787433,40.444590204197858 -85.493675586726496,40.448349072787984 -85.493749534077779,40.451836365223009 -85.493547449684741,40.451837198713619 -85.491118842489797,40.451847092761533 -85.485201633904481,40.451891304193389 -85.484219180109875,40.451891935998098 -85.474533086493025,40.451791518845909 -85.474360612975829,40.451789242199652 -85.470874776514961,40.451743174052538 -85.464736136008412,40.451643774099139 -85.464673710964988,40.451640466565998 -85.463268979764962,40.45156571927663 -85.458557073064924,40.451309285888556 -85.455051322020751,40.451104824720787 -85.455010452006036,40.451102656826926 -85.451106403472551,40.45089437237484 -85.448311367796435,40.45071274248221 -85.447554107942111,40.450698068634026 -85.446945145734645,40.450703399875287 -85.445345952004772,40.450794505981897</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-86.309234006876252,40.417294089219347 -86.306323642886753,40.417267655143128 -86.304507295190746,40.417264084582946 -86.301633976061822,40.417257440947459 -86.298973030438333,40.417259355266445 -86.295043113339588,40.417230955269822 -86.282452554915963,40.417275122011048 -86.28238099671583,40.417276254457974 -86.276124080827742,40.417375312361557 -86.273651806639776,40.417440888183727 -86.272521215905698,40.417487833983387 -86.27138079668218,40.417489661614646 -86.270384716139318,40.417501848449582 -86.269338866166962,40.417505694141603 -86.269077713067006,40.417506656042114 -86.268475603285836,40.41752537050796 -86.266637613623843,40.417522735555437 -86.264355862247527,40.417539771215139 -86.261968357188209,40.417596627438144 -86.257140978999928,40.417583729055458 -86.253804904288373,40.417544227667157 -86.252879027500654,40.417533743714877 -86.249987789305763,40.4175060149459 -86.246601492386944,40.417483997933914 -86.243195987716618,40.417461755999987 -86.236519394696657,40.417481867990148 -86.228187849578234,40.417547224914571 -86.22231212915419,40.417602445546414 -86.213011354038684,40.417679148890251 -86.212711403022624,40.417681611235338 -86.208379258015242,40.41771509290875 -86.203149285354783,40.417728714059095 -86.197509335682213,40.4178383526936 -86.193661510448422,40.417906174979066 -86.191462912418132,40.417931360659644 -86.189757803550748,40.417964468539061 -86.187817297646305,40.418027429357785 -86.186678850080682,40.418050957697027 -86.185162260888617,40.41808982832449 -86.184161586060014,40.418109798298076 -86.180502481597486,40.418165000546232 -86.176962055466689,40.418216427368009 -86.170786378341234,40.41826689291846 -86.170018640841377,40.418274897409063 -86.165147364632205,40.418298382558255 -86.162911154748627,40.418322753511966 -86.15852243061461,40.418399001802911 -86.154901295729672,40.418422138421526 -86.153449390421372,40.41843304774055 -86.153356263272329,40.418433716245694 -86.150035617474103,40.418458541091638 -86.14641988206256,40.418506495777827 -86.146105464899136,40.418510661344222 -86.13968511207392,40.418625225118852 -86.134903474339595,40.418720174491249 -86.133181302710213,40.418756824485044 -86.131496843168577,40.418784723140533 -86.128802376738022,40.418836701426024 -86.12792527288768,40.418828737302945 -86.127471289026587,40.41882860023258 -86.127193877140797,40.418828534179312 -86.124575957486002,40.418885587270488 -86.121475573726912,40.418947744652854 -86.117653406787653,40.419017735841329 -86.1161873926022,40.419011042421275 -86.115606751963355,40.419024620104096 -86.111405479388154,40.419064477073036 -86.10812110884568,40.419079726963382 -86.105005685317309,40.419127722936928 -86.103724250945433,40.419157299154016 -86.103479558284363,40.419156438847125 -86.102908580210993,40.419161018689763 -86.10168305682555,40.419187538551512 -86.100138781618213,40.419198051390346 -86.09586439122144,40.419182224992049 -86.09369411426276,40.419226267716184 -86.092520346836949,40.419250077228078 -86.092121556358066,40.419258164225347 -86.090899762973137,40.419282931469489 -86.089058849301367,40.419320242416504 -86.087566894621148,40.419349017445143 -86.079672630075933,40.419500902365627 -86.069922517706203,40.419594044674014 -86.063830797183272,40.419689019851667 -86.060573135833934,40.419739170632866 -86.055108109697869,40.419852290151994 -86.051177614608392,40.419914692863919 -86.042942978618257,40.419995464411798 -86.041567088259868,40.420029110806105 -86.040733870721652,40.420026704668352 -86.03933005538633,40.420051083774041 -86.035047240293991,40.420128027566626 -86.031983175789094,40.420159798201716 -86.031920162772408,40.420160442626923 -86.024322782164234,40.42023621292978 -86.016731215304844,40.420320542163751 -86.012735358126022,40.420363063599858 -86.010639106567737,40.420381178881023 -86.00154510813644,40.420384076219158 -85.996794241625423,40.420419523346943 -85.994520092769662,40.420462829158183 -85.985002950578348,40.420573355365448 -85.97551445198286,40.420647315964892 -85.97021820414011,40.420694854054069 -85.966680918687459,40.420712840218719 -85.956642995928036,40.420770068162383 -85.956556821919463,40.420770552552924 -85.948995447038698,40.420846200212885 -85.942323269883772,40.420920482865661 -85.938982405683689,40.420957435895822 -85.932806202225763,40.421022206613038 -85.925638586996413,40.421072933532372 -85.918620459981753,40.421129118746499 -85.914990287742413,40.421149158260036 -85.909104534768474,40.421156830117155 -85.905483277192459,40.421172150673698 -85.899691537314851,40.421193746501814 -85.89503165543681,40.421203353881502 -85.890727821531499,40.421198172583416 -85.887424930468455,40.421206972813785 -85.882756665095854,40.421188977950806 -85.878832406053107,40.421218552422388 -85.876486836692266,40.421245193301708 -85.870063781584037,40.421317860687878 -85.862204413500606,40.421407438470098</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-84.97809324645209,40.43950496770708 -84.978091670983645,40.439460098288961 -84.978072510603184,40.438273171843107 -84.978056680895278,40.437292607001503 -84.978049922869189,40.436874009210797 -84.978028196135128,40.436325661721675 -84.977989179836555,40.435340912844943 -84.97795128276897,40.434384412468184 -84.977934103215688,40.433950797399021 -84.977919039691741,40.433374621833963 -84.977891918782532,40.432337225778717 -84.977892105771375,40.432216646276096</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-85.150531512991037,40.450878928810518 -85.150531269492433,40.450144813405572 -85.150530032539223,40.447971077900959 -85.150507224207999,40.446411952613587 -85.150480247188753,40.444495218587456 -85.150472923419699,40.44390874744726 -85.150472718825085,40.44389517652521</coordinates></LineString></MultiGeometry> </Placemark> <Placemark> <style><LineStyle><color>ff0000ff</color><width>5</width></LineStyle><PolyStyle><fill>0</fill></PolyStyle></style> <MultiGeometry><LineString><coordinates>-85.150548363910133,40.451174567539958 -85.15053159495244,40.451126233042864 -85.150531512991037,40.450878928810518</coordinates></LineString></MultiGeometry> </Placemark> </Folder> </Document></kml><?xml version="1.0" encoding="UTF-8"?> <kml xmlns="http://www.opengis.net/kml/2.2" xmlns:gx="http://www.google.com/kml/ext/2.2" xmlns:kml="http://www.opengis.net/kml/2.2" xmlns:atom="http://www.w3.org/2005/Atom"> <Document> <name>Wyoming Highway 72.kml</name> <StyleMap id="m_ylw-pushpin"> <Pair> <key>normal</key> <styleUrl>#s_ylw-pushpin</styleUrl> </Pair> <Pair> <key>highlight</key> <styleUrl>#s_ylw-pushpin_hl</styleUrl> </Pair> </StyleMap> <style id='s_ylw-pushpin'> <IconStyle> <scale>1.1</scale> <Icon> <href>http://maps.google.com/mapfiles/kml/pushpin/ylw-pushpin.png</href> </Icon> <hotSpot x="20" y="2" xunits="pixels" yunits="pixels"/> </IconStyle> <LineStyle> <color>ff0000ff</color> <width>5</width> </LineStyle> </style> <style id='s_ylw-pushpin_hl'> <IconStyle> <scale>1.3</scale> <Icon> <href>http://maps.google.com/mapfiles/kml/pushpin/ylw-pushpin.png</href> </Icon> <hotSpot x="20" y="2" xunits="pixels" yunits="pixels"/> </IconStyle> <LineStyle> <color>ff0000ff</color> <width>5</width> </LineStyle> </style> <Placemark> <name>Wyoming Highway 72</name> <styleUrl>#m_ylw-pushpin</styleUrl> <LineString> <tessellate>1</tessellate> <coordinates> -106.4133548727842,41.68686820185751,0 -106.4138153239002,41.68729001758322,0 -106.4148949478451,41.68824469308047,0 -106.4152666071086,41.68850794412952,0 -106.4155353232533,41.6886523022292,0 -106.4159416561545,41.68880154236862,0 -106.4164036824205,41.68890672836899,0 -106.4180322462046,41.68919534506554,0 -106.4213835460132,41.68978731819843,0 -106.4220744673233,41.6899353968352,0 -106.4226708020998,41.69010903713141,0 -106.4231360874558,41.690292476406,0 -106.4235882760363,41.69052729340582,0 -106.42402081012,41.69079635958971,0 -106.4243968828726,41.69110684198058,0 -106.4247409712921,41.69143707821835,0 -106.4251910526906,41.69191816060425,0 -106.4265283132016,41.69345116611547,0 -106.4283651493501,41.69550252533777,0 -106.4302049456642,41.69758089071037,0 -106.4321068597199,41.69971054024618,0 -106.4339727050882,41.70180278553496,0 -106.4358637719374,41.7039326469511,0 -106.4377408334827,41.70603122456571,0 -106.4394890696126,41.70798654067816,0 -106.4413786955711,41.71010987813325,0 -106.4431946371949,41.71213579368154,0 -106.4449305068498,41.7140994951813,0 -106.4455696170708,41.71481744147363,0 -106.44603203766,41.71526258256842,0 -106.4465240383473,41.71570044443983,0 -106.447006227811,41.7160478252684,0 -106.4476375321461,41.71645627180843,0 -106.4483262346724,41.71683045462085,0 -106.448924022683,41.71711484124391,0 -106.4495503523083,41.71735689057499,0 -106.4504193207602,41.71763799378924,0 -106.4542451656539,41.7188471721689,0 -106.4564555811479,41.71954771837342,0 -106.4571047337777,41.71979453619118,0 -106.4576882788576,41.72008292782137,0 -106.4581979805995,41.72043761556638,0 -106.4586209562131,41.72079698689215,0 -106.4589816855488,41.72120526822162,0 -106.4592457513326,41.72157894099752,0 -106.4594852919915,41.72206550474209,0 -106.4596396392011,41.72257551312781,0 -106.4597088338255,41.7230471321758,0 -106.4597389621376,41.72369582470313,0 -106.459835250536,41.72568317808283,0 -106.4599020284947,41.72734766101855,0 -106.4599917555321,41.72914763502386,0 -106.4600846779002,41.73085361910337,0 -106.4601307406187,41.7316154151073,0 -106.4601081542496,41.73203907545774,0 -106.4600462694714,41.73245453356882,0 -106.4599254458811,41.73285528743235,0 -106.459752229318,41.73322666291575,0 -106.4594939816052,41.73366159823598,0 -106.4584897708529,41.73533633110579,0 -106.4581204345418,41.73600433172142,0 -106.4579211847001,41.73649091030008,0 -106.4574804776659,41.73778606139452,0 -106.4568962241741,41.73949252276898,0 -106.4567265328397,41.74006163734783,0 -106.456651631723,41.74055968129021,0 -106.4566290001106,41.74098973471924,0 -106.4566489008529,41.74144873813127,0 -106.4566981633153,41.7418406607914,0 -106.4568031355181,41.74229483278023,0 -106.4569539309604,41.74273113389203,0 -106.4571866243344,41.74328302969168,0 -106.4574619010892,41.74375222871075,0 -106.4578256660865,41.74428946160577,0 -106.458146782277,41.74465720377369,0 -106.4584941110819,41.74500152914174,0 -106.4590020215762,41.74541057378761,0 -106.4595788229233,41.74583058593444,0 -106.4602441012866,41.74621473398103,0 -106.4611290933043,41.74668355817532,0 -106.462987805214,41.74762250584665,0 -106.4660102800805,41.74918539760122,0 -106.4670273015225,41.74972044530795,0 -106.4675686005221,41.75004305659414,0 -106.4681658112898,41.75044641747638,0 -106.4687423853337,41.75089201973157,0 -106.4692183970729,41.75132240682653,0 -106.4697040541926,41.75180857845306,0 -106.4701507099379,41.75235160926484,0 -106.4705088226218,41.7528386068367,0 -106.4708505540477,41.75340131306335,0 -106.4711551792365,41.7539965965826,0 -106.471405115122,41.75459704822954,0 -106.4715828791924,41.75519982617425,0 -106.471932179615,41.75658300734477,0 -106.4724166606619,41.75861022548687,0 -106.4729175773431,41.76061246647726,0 -106.4734284486518,41.76264927509637,0 -106.4739954479182,41.76494206529677,0 -106.4745558647445,41.76718753552826,0 -106.4750901858185,41.76935064330669,0 -106.4756115480543,41.77149584381687,0 -106.4761612813199,41.77363437252245,0 -106.4766958148381,41.77579193358392,0 -106.477193986753,41.77784342718914,0 -106.4773529199167,41.77841057968001,0 -106.4775243072928,41.7789274049123,0 -106.4777186594668,41.7794050358922,0 -106.4780182439259,41.7799400238203,0 -106.4784166292088,41.78058672464918,0 -106.4790032810807,41.78150469873381,0 -106.4799580502472,41.78298328132397,0 -106.4810919020866,41.78479494357991,0 -106.4822044285141,41.78651293334931,0 -106.4833344667133,41.78830415536838,0 -106.4844810210359,41.79012354304923,0 -106.4849648533257,41.79098179637042,0 -106.4853337971365,41.79174923340885,0 -106.4856238645368,41.79248567543748,0 -106.4859207992403,41.7934170220972,0 -106.4861717964802,41.79432767375208,0 -106.4867195096437,41.79638398686875,0 -106.4872746023333,41.79844992878973,0 -106.4878728871011,41.80059862874616,0 -106.4884846926183,41.80285404413151,0 -106.4887171916908,41.8036987220809,0 -106.4889086738085,41.80416717666173,0 -106.4891429129767,41.80461838425723,0 -106.4894429530027,41.80507887076012,0 -106.4897724479771,41.8054367324779,0 -106.4901587617486,41.80581968537457,0 -106.4905606218,41.80616520117847,0 -106.4909919929151,41.80645915953863,0 -106.4915482774993,41.80678994873216,0 -106.4941319711665,41.80825490948769,0 -106.4948145090353,41.80865494875508,0 -106.4953773421208,41.80905649965781,0 -106.4958546299656,41.80947275017552,0 -106.4962792533452,41.80990894439303,0 -106.4966808593842,41.81040603426942,0 -106.4969772270671,41.81084270229252,0 -106.4972308743796,41.8113250830826,0 -106.4974516814943,41.81186349508869,0 -106.498188662485,41.81379879741228,0 -106.4987096628,41.81516365785178,0 -106.4989106433358,41.81558219492664,0 -106.4991820375687,41.81603028641609,0 -106.4995013149629,41.81643155322795,0 -106.4998993386328,41.81681309169508,0 -106.5003115569712,41.81712866786647,0 -106.5007487827333,41.81739023079454,0 -106.5012910348425,41.81765901194926,0 -106.5018594280197,41.81787879361252,0 -106.50250984363,41.81807891559175,0 -106.5041979604772,41.81858523816391,0 -106.5053673679247,41.8189855433402,0 -106.5063710862615,41.81938286746149,0 -106.5075869485472,41.81993244721635,0 -106.5107480715308,41.82137155783992,0 -106.5129986531464,41.82239624885027,0 -106.5138835799827,41.82281432714912,0 -106.5145791306823,41.82321409868706,0 -106.5152439643685,41.82365447465433,0 -106.5159387850739,41.82421745346812,0 -106.5178719683875,41.82584710531338,0 -106.5207970276537,41.82828256470885,0 -106.5232547523956,41.83035151091304,0 -106.5250700905838,41.83187435991513,0 -106.5262995351131,41.83300015190998,0 -106.5273306552254,41.83400898482434,0 -106.5281988637335,41.83496279192645,0 -106.5297307566915,41.83663398798286,0 -106.5313515106753,41.83839597160885,0 -106.5330271928351,41.84024324310864,0 -106.5334247544932,41.84064422104689,0 -106.5341109087698,41.84123730256966,0 -106.5348202123823,41.84179369613192,0 -106.5353417862537,41.84227866486314,0 -106.5357250759669,41.84273734656789,0 -106.5361551274083,41.84334115228008,0 -106.5368066072294,41.84432537707153,0 -106.537357302008,41.84503641342294,0 -106.5378299076782,41.84558852770348,0 -106.5384900473753,41.84629455974121,0 -106.5391300385502,41.84690020026706,0 -106.5398170331652,41.84750604303364,0 -106.540559661801,41.84808786673019,0 -106.5412068512518,41.84855625077226,0 -106.5420553437634,41.84912100212954,0 -106.5441228469547,41.85052836021389,0 -106.546651458335,41.85225716857109,0 -106.5489638716143,41.85385170614966,0 -106.5493715326853,41.85412895765436,0 -106.5516161008464,41.85566171923145,0 -106.5541104370218,41.85735747375279,0 -106.5549356792307,41.85795934136102,0 -106.55579443381,41.85862781789062,0 -106.5566866987766,41.85941430880269,0 -106.5576888504579,41.86038748396658,0 -106.5588627826066,41.8614858835459,0 -106.5603338620663,41.86288362323248,0 -106.562309121592,41.8647480490366,0 -106.5640612239798,41.86640136948856,0 -106.5643199302174,41.86670516883942,0 -106.5644294547715,41.8669483750731,0 -106.5644762701996,41.86719413426211,0 -106.5644737142924,41.86749407242679,0 -106.5643834158587,41.86836337028226,0 -106.5643132737537,41.86939156029514,0 -106.5642577279145,41.86963018124374,0 -106.5641262471214,41.86986141281894,0 -106.5638762267569,41.87020337834843,0 -106.562324463846,41.869932575847,0 -106.5599892701353,41.86950311495219,0 -106.5593787384592,41.86944246249772,0 -106.5587547962408,41.86941131573767,0 -106.5581903516964,41.86943170905204,0 -106.557540146939,41.86950137641096,0 -106.5569601544348,41.86960782954379,0 -106.5564124867377,41.86975849079437,0 -106.5557537236789,41.86997812333465,0 -106.5528148893014,41.87101923663357,0 -106.5493077021794,41.87224430639389,0 -106.5462759943475,41.87333620609158,0 -106.5427326227826,41.87458923651162,0 -106.539470244936,41.87573904227519,0 -106.5367100931929,41.87671378556548,0 -106.5347842470443,41.87741743638953,0 -106.5340213505538,41.87773816853573,0 -106.5336652446163,41.87787368824827,0 </coordinates> </LineString> </Placemark> </Document> </kml><ref>​
  3. 1 2 3 "Entrez Gene: CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase".
  4. ↑ "Entrez Gene: DHODH dihydroorotate dehydrogenase".
  5. 1 2 "Entrez Gene: UMPS uridine monophosphate synthetase".
  6. ↑ "Entrez Gene: UCK2 uridine-cytidine kinase 2".
  7. ↑ Chitrakar I, Kim-Holzapfel DM, Zhou W, French JB (March 2017). "Higher order structures in purine and pyrimidine metabolism". Journal of Structural Biology. 197 (3): 354–364. doi:10.1016/j.jsb.2017.01.003. PMID 28115257.
  8. ↑ Garavito MF, Narváez-Ortiz HY, Zimmermann BH (May 2015). "Pyrimidine Metabolism: Dynamic and Versatile Pathways in Pathogens and Cellular Development". Journal of Genetics and Genomics = Yi Chuan Xue Bao. 42 (5): 195–205. doi:10.1016/j.jgg.2015.04.004. PMID 26059768.
  9. ↑ Nielsen HR, Sjolin KE, Nyholm K, Baliga BS, Wong R, Borek E (June 1974). "Beta-aminoisobutyric acid, a new probe for the metabolism of DNA and RNA in normal and tumorous tissue". Cancer Research. 34 (6): 1381–4. PMID 4363656.
  10. ↑ Jones ME (June 1980). "Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis". Annual Review of Biochemistry. 49 (1): 253–79. doi:10.1146/annurev.bi.49.070180.001345. PMID 6105839.
  11. ↑ Alqahtani, Saad Saeed; Koltai, Tomas; Ibrahim, Muntaser E.; Bashir, Adil H. H.; Alhoufie, Sari T. S.; Ahmed, Samrein B. M.; Molfetta, Daria Di; Carvalho, Tiago M. A.; Cardone, Rosa Angela; Reshkin, Stephan Joel; Hifny, Abdelhameed; Ahmed, Mohamed E.; Alfarouk, Khalid Omer (6 July 2022). "Role of pH in Regulating Cancer Pyrimidine Synthesis". Journal of Xenobiotics. 12 (3): 158–180. doi:10.3390/jox12030014. PMC 9326563.
  12. ↑ Becker S, Feldmann J, Wiedemann S, Okamura H, Schneider C, Iwan K, Crisp A, Rossa M, Amatov T, Carell T. Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides. Science. 2019 Oct 4;366(6461):76-82. doi: 10.1126/science.aax2747. PMID 31604305
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.