Mojo Jojo steals a magical Anubis dog head and unleashes a curse that turns everyone into dogs, including the Powerpuff Girls, but the three sniff out a solution and show Mojo Jojo that their bite is worse than his bark.

Vile villain Roach Coach plots to infest Townsville with his army of cockroaches. The girls must fight their fear of bugs in order to squash Roach Coach's scheme and force him to bug off.

The heinous Him toys with Bubbles' mind by speaking to her through Octi, her favorite stuffed animal. Following its instruction, Bubbles provokes a fight between her sisters that prompts the Professor to issue a time-out until the girls can make amends and make squid-meat out of the now giant, Him-controlled Octi.

Buttercup develops a crush on Ace, the leader of the Ganggreen Gang. However, when the gang exploits her infatuation and lures Blossom and Bubbles into danger, Buttercup quickly comes to her sisters' rescue and shows the boys the real meaning of the word "crush."

Bubbles must face her fear of the Boogie Man after he blocks out the sun and allow his monster friends to party all the time.

The Ganggreen Gang gets hold of the Mayor's hotline to the Powerpuff Girls and makes prank calls, sending the Girls on a wild goose chase all over town. However, when it's the notorious villains Mojo Jojo, Fuzzy, and Him that the gang disturbs, they learn the price of making prank calls.

There's a new man in town: Major Man, an impossibly perfect superhero who cuts in on the Girls' turf. Unfortunately, Major Man isn't as perfect as he is supposed to be as the girls soon discover, and come up with an idea to make Major Man reveal the fraud that he is in the midst of a monster attack.

Buttercup teases paste-eating classmate Elmer. When a fly with atomic chemicals enters into the paste, Elmer turns into a destructive Paste Monster. Buttercup has to get out of a sticky situation by doing something against her tough nature—apologizing.

Bubbles is tired of people dismissing her as more sugar than spice, especially the Professor and her sisters, who treat her like a baby. When she sets out to prove she is hardcore, she takes everyone by surprise, even Mojo Jojo.

Bubbles saves a seemingly innocent little cat from the clutches of an evil villain, but when the girls discover it's actually the cat who is evil, they must save the Professor from becoming the "purr-fect" victim.

After the Powerpuff Girls lose their baseball in Mojo Jojo's window, it seems to offer the evil villain the perfect opportunity to destroy the pesky superheroes. Unfortunately, he gets more than he bargained for when the Girls treat it like a visit to his house, just to cause trouble over a baseball.

The new girl in school, Princess Morbucks, wants to be a Powerpuff Girl after discovering they have superpowers, one thing she doesn't have. However, when Princess is denied the opportunity to join the Girls because of her spoiled, bratty behavior, they make a very snobbish new enemy, intent on destroying them.

A comic book geek named Lenny Baxter goes too far to complete his superhero collection when he traps the girls inside his power packages. Now, it's up to the people of Townsville to save the day.

While in prison, Mojo Jojo, Princess Morbucks, and the Amoeba Boys all come up with plans to destroy the Girls at their television-covered birthday party. Later on, Him tries a plan of his own, using the pinata featured at the party.

Broccoli aliens land in Townsville with a plan to harvest all the Earth's vegetables, and the only way to beat the broccoli is to eat it. The Girls are able to defeat their most detested side dish with help from other kids in town.

The Sandman wants to get some sleep, but can't as long as half the world is awake at any given time, so he builds a machine that will sprinkle the world with his sand and put everyone to sleep, leaving it to the Powerpuff Girls to fight the Sandman in his dreams to make him wake up.

After being saved from a rushing train by the Girls, Big Billy defects from the Ganggreen Gang and pledges his loyalty to the Girls. Unfortunately, this leads to him getting in the way of their crime fighting.

After a big battle, Blossom discovers the perfect (and otherwise impossibly priced) Father's Day gift for the Professor among the rubble, leading to feelings of guilt and suspicion of theft from Bubbles and Buttercup. When Professor gets arrested, Blossom realizes she must confess after failing to convince them that Mojo did the stealing.

Princess Morbucks is tired of failing to come up with a good plot to destroy the Powerpuff Girls, so she hires Mojo Jojo to create a brilliant plan to strip the Powerpuff Girls of their powers. However, the plan eventually fails, and Princess Morbucks and Mojo are sent to jail.

A new boy in school creates an imaginary friend named Patches who starts causing trouble, with the boy getting blamed for most of Patches' antics. When the true culprit is discovered, the solution to stop Patches is another imaginary friend from the Powerpuff Girls.

On a rainy day, because there isn't a crime to be found in the city, the Girls make their own crime fighting adventure inside their home using the power of their imagination.

The Girls need an extra hand at saving the day and attempt to create a fourth Powerpuff Girl, named "Bunny." However, when they don't quite duplicate the famous ingredients that Powerpuff Girls are made of, Bunny comes out less than expected, releasing villains from jail and fighting the police. The Girls eventually tell her that she is doing everything wrong, and when they subsequently get into more trouble than they can handle, Bunny saves them. Unfortunately, she explodes at the end of the episode due to being unstable.

A race home from school finds the Girls breaking the speed of light and traveling to an alternate future, where the day they had traveled to the future meant they mysteriously disappeared from history, leaving the world for 50 years with their absence, as well as everything and everyone in the clutches of their most evil enemy—Him.

Ms. Bellum begins using her feminine wiles to coax the Mayor into giving her time off, but it turns out she wants to commit crimes. When something seems amiss, the Powerpuff Girls investigate and find out that "Ms. Bellum" is actually the villainess Sedusa in disguise.

A trio of old villains called the Ministry of Pain return, and the girls intend to fight them, but Blossom mentions that fighting their elders is the wrong way to approach the situation, and they must respect them for their age, leading to the Ministry going on a crime spree where Blossom refuses to let her sisters bring them to justice because of their old age to "respect their elders". She finds a possible situation: recruit the former heroes, Captain Righteous, and his sidekick, Lefty, who used to fight against the Ministry of Pain. Unfortunately, these former heroes cannot agree with each other and Blossom's plan backfires when all five men suffer injuries and get taken to the hospital's intensive care unit.

When the Professor gets a job offer at a research lab in the town of Citiesville, he and the girls move there. The girls are quick to offer their help to the city; however, the high degree of property damage that they cause prompts the Mayor of Citiesville to reject the use of super powers. When the girls tell the Professor that they hate living in Citiesville, he reveals that he hates it too and they all agree that they should move back to Townsville.

When Bubbles can't take a direct hit at The Giant Ant, the Professor does some tests and it turns out that her eye vision has gone blurry as she looks in all directions even when talking to someone face to face. As she gets glasses, she gets made fun of by Blossom and Buttercup, who call her things like "dork" and "nerd".

Mitch Mitchelson is an evil pet sitter for the class hamster Twiggy. He pretends to be nice to her around the others, but the girls see through Mitch's superficial niceness and soon Twiggy is turned into a monster.

An undefeatable monster comes to Townsville, with Blossom (using team tactics) and Buttercup (using direct action) disagreeing on how to defeat the monster. On the other hand, Bubbles uses her "sugar" personality, by asking the monster to leave, which surprisingly ends up working well.

A clumsy robber gets away from the girls with a diamond, but ends up losing it in a box of 'Lucky Captain Rabbit King' cereal. It just so happens that Professor Utonium happened to buy the box the diamond is in. The robber disguises himself as the character Lucky Captain Rabbit King, but his 'costumed attempts' meet with failure.

The girls get a reward for saving the day: candy, which they quickly grow an addiction to. When nothing happens in Townsville, they convince Mojo Jojo to do crimes so they can get awarded and then the girls will bust him out the next day. When Mojo steals the Mayor's candy, the Girls learn what the extra sugar has done to them.

The Mayor tries to save Townsville after being criticized by the nighttime cleaning staff woman that he just sits there and does nothing. He then causes destruction and the girls have to quickly find him before he inadvertently destroys the city in a hot air balloon.

A little leech man sucks information from other people's brains. People find it hard to remember what happened after this, so the girls then use the Mayor as a defense to give the leech nothing.

After the girls do chores around the house, the Professor awards them with a Sacagawea dollar each. Buttercup is so ecstatic that she accidentally knocks out one of Bubbles' teeth. However, her sadness turns to greed when Bubbles receives a dollar from the tooth fairy. Buttercup then proceeds to knock out the teeth of numerous villains, and starts hoarding the money she receives. As it comes to a head, Mojo Jojo, Fuzzy Lumpkins, Him, the Ganggreen Gang, and countless thugs decide to teach her a lesson by breaking her teeth and using her money savings with the Professor to pay for her dentist bills.

This episode is laden with The Beatles references.

Bubbles' love for animals goes too far. After the Professor finds animals in the closet, she is told to stop bringing these animals home. She now has to keep her newest animal, a baby whale, out of the Professor's eyes, but her chance starts to drown when the whale dries up.

The Professor and Miss Keane go out on a date set up by the girls, though Ms. Keane and Professor get distracted from using the hotline so much that the Mayor cannot reach the girls.

When the Mayor finds the deed to Monster Isle, the monsters move to Townsville causing havoc between monsters and humans. The girls try to keep the peace and let everyone in Townsville live in harmony, but when Townsville gets far too crowded, the girls trick the Mayor into giving back Monster Isle to all the monsters.

When the Mayor's toaster is broken, he gives it to the Professor to fix it, and he accidentally discovers the Professor's secret stash of Chemical X. He believes that it is a hair growth formula, but instead, The Chemical X makes the Mayor grow huge and it is up to the Powerpuff Girls to calm him down and return him down to size without constantly telling him that he's a "baby".

The girls realize that the Professor is tired after preparing for his dissertation tomorrow, so when a burglar new to Townsville tries to rob them, the girls try to stop him without waking up the Professor.

When the Powerpuff Girls try to stop Mojo Jojo from doing a crime, an animal activist group comes to his rescue protesting that the Powerpuff Girls can't harm him because he is an endangered animal. With this knowledge, Mojo takes advantage of their protest and commits more crimes, until a loophole in the law puts Mojo into the woods full of monkeys and apes.

The girls find their bed soaking wet, but they refuse to admit that they did it, quickly distracting them with fear, not knowing that Mojo Jojo is just passing by accident.

A frozen caveman and mastodon at the museum thaws out and goes out to steal the seeds of Townsville, which makes the Mayor his top target.

A clip show episode that reflects on the past four seasons. The episode features some clips that did not actually happen.

The girls' (and Professor's) little white lies turn into a big problem when a monster starts to grow and make trouble around the house.

A filmmaker makes a documentary on the Powerpuff Girls, but can't get a good clip of them.

Bubbles overhears a bad word from the Professor. Then her sisters start to use it, too, which causes a shocking reaction around Townsville. When a giant potty mouth monster comes to attack, the Professor tells the girls what the "word" means and the girls teach the potty mouth a lesson.

At the silent movie theater the girls reluctantly attend, a silent film star captures the Professor. The girls must go inside the black and white film (without sound) and bring him back to the real world (with sound), without their powers.

Back when Mojo tried to take over the world with primates (during the events of The Powerpuff Girls Movie), there was one monkey who didn't get his due: Mopey Popo. Now, Mopey is back to try and be evil just as Mojo intended, if only he could get something right.

Buttercup has to find inner peace after she is accused of being way too aggressive on Fuzzy Lumpkins.

Realizing the need for the Professor to win the chili contest, the girls each unknowingly add Chemical X to give it an extra kick. After the Professor wins the contest and having everyone tasting the chili, they all let out the gas which causes a gas monster to come out of the sewers and makes an awful stench around Townsville, affecting the civilians and it's up to the Girls to save the day from that monster stench.

When Mojo agrees to do some community service in lieu of jail-time by teaching at the Townsville Community College, he teaches his lengthy speeches to the people of Townsville, putting the city in a total standstill unless the girls can find someone with simple English to end the long-winding conversations.

The girls misinterpret the Professor's plans for a surprise party, instead assuming that he is making new Powerpuff Girls.

When Mojo discovers that the Rowdyruff Boys have returned, he competes with Him to determine who's the more evil father.

The girls rescue a baby from a monster and are forced to care for it when they can't find its mother.

The Powerpuff Girls get sunburned fighting a solar flare and are unable to fight even the lowly street criminals.

Mojo Jojo manages to attach the Powerpuff Girls to each other, worsening the arguments they often have.

The Professor takes the girls on a camping trip to teach them to relax, but they are interrupted by Fuzzy Lumpkins and his three nephews and not even he can keep peace.

Buttercup tries to figure out her special ability, jealous of Bubbles' many languages and Blossom's ice breath. Fortunately, only Buttercup is able to curl her tongue.

The girls try to catch a pickpocketing false psychic (June Foray) that stole the Mayor's key.