NFATC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A66, 1NFA
Identifiers
Aliases	NFATC1, NF-ATC, NFAT2, NFATc, NF-ATc1.2, nuclear factor of activated T-cells 1, nuclear factor of activated T cells 1
External IDs	OMIM: 600489 MGI: 102469 HomoloGene: 32336 GeneCards: NFATC1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q23 Start 79,395,856 bp[1] End 79,529,325 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E3|18 53.66 cM Start 80,649,420 bp[2] End 80,756,286 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte triceps brachii muscle gastrocnemius muscle sural nerve vastus lateralis muscle periodontal fiber deltoid muscle lymph node hair follicle Top expressed in endocardial cushion triceps brachii muscle olfactory epithelium knee joint temporal muscle blood ankle sternocleidomastoid muscle spleen digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity mitogen-activated protein kinase p38 binding FK506 binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding transcription factor binding Cellular component cytoplasm cytosol nucleus nucleoplasm nuclear body transcription regulator complex Biological process intracellular signal transduction regulation of transcription, DNA-templated calcineurin-NFAT signaling cascade transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated Fc-epsilon receptor signaling pathway positive regulation of transcription by RNA polymerase II Wnt signaling pathway, calcium modulating pathway negative regulation of Wnt signaling pathway negative regulation of vascular associated smooth muscle cell differentiation cytokine production aortic valve morphogenesis pulmonary valve morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4772 18018 Ensembl ENSG00000131196 ENSMUSG00000033016 UniProt O95644 O88942 RefSeq (mRNA) NM_172390 NM_001278669 NM_001278670 NM_001278672 NM_001278673 NM_001278675 NM_006162 NM_172387 NM_172388 NM_172389 NM_001164109 NM_001164110 NM_001164111 NM_001164112 NM_016791 NM_198429 RefSeq (protein) NP_001265598 NP_001265599 NP_001265601 NP_001265602 NP_001265604 NP_006153 NP_765975 NP_765976 NP_765977 NP_765978 n/a Location (UCSC) Chr 18: 79.4 – 79.53 Mb Chr 18: 80.65 – 80.76 Mb PubMed search [3] [4]
Wikidata
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Nuclear factor of activated T-cells, cytoplasmic 1 is a protein that in humans is encoded by the NFATC1 gene.^[5]

Function

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as ciclosporin. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.^[6]

Interactions

NFATC1 has been shown to interact with PIM1.^[7]

See also

• NFAT

References

Further reading

External links

• NFATC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.