(1) Chicago Bulls vs. (8) Philadelphia 76ers

The Bulls came into the playoffs as the first overall seed for the second straight year. The 76ers, meanwhile, came into the playoffs as the team with the worst record in the playoffs. The Bulls made quick work of the 76ers, winning Game 1. However, with the Bulls leading by 12 with 1:20 to go in the fourth, Derrick Rose tore his ACL and he was ruled out for the playoffs, putting the Bulls championship hopes in serious jeopardy. The 76ers took the next three games to put the Bulls in the brink of elimination. In Game 3, Joakim Noah was injured when he stepped on Andre Iguodala's foot, ruling him out for the next two games. The Bulls staved off elimination by winning Game 5 at home. In Game 6, with the Bulls up 1 with 7 seconds to go, Ömer Aşık missed two crucial free-throws. Iguodala managed to rebound the ball and sprinted to the other side of the court. He got fouled by Aşık while going for a shot. Iguodala gave the 76ers the lead by making the free-throws. The Bulls, who were out of timeouts, had one last chance to force a Game 7 but C. J. Watson's halfcourt heave bounced off the back of the rim, giving the 76ers the series. They advanced to the semifinals for the first time since 2003. The Bulls, meanwhile, became the fifth first-seeded team to be upset by the eighth-seed.

Regular-season series

This was the third playoff meeting between these two teams, with the Bulls winning the first two meetings.

(2) Miami Heat vs. (7) New York Knicks

The Heat defeated the Knicks in Game 1 by 33 points. Game 2 was much closer, even without Knicks' starting rookie guard Iman Shumpert who suffered an ACL injury the previous game, but the Heat still won by 10. In Game 3 in MSG, the Heat found themselves on the wrong end in the first half, trailing by as much as 11 points, before closing the half with a 7–0 run. The Heat led by 2 after the 3rd quarter. However, LeBron James quickly sparked an 8–0 run to start the 4th quarter, giving them a 10-point lead. The Knicks never recovered. James himself outscored the Knicks in the fourth, 17–14. By losing Game 3, the Knicks set a new league record by losing 13 straight playoff games, their last win coming April 29, 2001, in their series versus the Raptors.^[6] In Game 4, Knicks' starting guard Baron Davis injured himself in the third quarter and had to be carried off the court on a stretcher. But led by Carmelo Anthony's 41, the Knicks won 89–87, escaping a sweep as Wade's potential series-winning 3 missed at the buzzer. In Game 5, the Knicks started strong but Miami took over the rest of the way. The Heat led by 11 at the end of the first half. The Heat never squandered the lead, effectively sealing the game and the series with a 3-pointer by Battier that gave the Heat a 14-point lead with a minute left in the game. The Knicks were led by Anthony's 35. Amar'e Stoudemire, meanwhile, was plagued by foul trouble. He fouled out with about 4 minutes left in the game.

Regular-season series

This was the fifth playoff meeting between these two teams, with the Knicks winning three of the first four meetings.

(3) Indiana Pacers vs. (6) Orlando Magic

The Pacers were considered the heavy favorites in the series as the Magic would try to defeat the Pacers without Dwight Howard. The Magic defied the odds in Game 1, as the Pacers went scoreless in the final 4 minutes of the game, allowing the Magic to go on an 11–0 run to finish the game and take a 1–0 series lead. The Pacers quickly took revenge, winning the next two games at home and on the road by an average of 19 points. Game 4 was close, with the game going to overtime. However, George Hill hit two free-throws with 2 seconds left to give the Pacers a 3–1 lead in the series. Game 5 was close throughout the first three quarters, with Magic taking a two-point lead heading to the 4th quarter. However, Indiana outscored the Magic 36–16 in the fourth to give the Pacers the series victory 4–1. This would be last playoff appearance for the Magic until 2019.

Regular-season series

This was the third playoff meeting between these two teams, with each team winning one series apiece.

(4) Atlanta Hawks vs. (5) Boston Celtics

The Hawks had homecourt advantage for the series despite being the lower seeded team by having the better season-record of the two; the Celtics took the 4th-seed by winning their division title. The Hawks won Game 1 by nine points, but the Celtics took the next three games, pushing the Hawks to the brink of elimination. Games 2 and 3 were close victories for the Celtics with Game 4 being a blowout victory for them. Game 5 in Atlanta was a close one. In the final seconds, with the Hawks up by one, Rajon Rondo stole an inbound pass, giving the Celtics a chance to finish off the Hawks. However, Josh Smith stripped a Rondo pass intended for Kevin Garnett, letting the Hawks survive and force a Game 6. In Game 6, Garnett led the Celtics to an 83–80 victory and advance. The Hawks had a chance to tie the game through free throws. However, Al Horford missed his first free throw that could have cut the lead to one. It was the Hawks' only miss at the free throw line the entire night. He made his second to cut it to one and the Hawks quickly fouled Paul Pierce. Pierce made both free throws to extend Celtics' lead to 3. With a chance to tie the game, Jeff Teague fumbled a pass, sealing the series for Boston.

Regular-season series

This was the 11th playoff meeting between these two teams, with the Celtics winning nine of the first ten meetings.

(1) San Antonio Spurs vs. (8) Utah Jazz

The Spurs were touted the heavy favorites in the series, following their 10-game winning streak to end the regular season and their 3–1 season series victory over the Jazz. They quickly worked their way through the Jazz, scoring 31 points in the third quarter to blow the game open. They eventually won Game 1 106–91. In Game 2, the Spurs shot 10 three-pointers and shot more than 50% as they blew out the Jazz 114–83 to take a 2–0 series lead. Game 3 was close throughout the first half, with the Spurs leading only by 2 after the first half. However, the Spurs blew the game open in the second half and won by 12 to take a 3–0 lead in the series. The odds were stacked against the Jazz as no team in NBA history have managed to win a series after trailing 3–0. Notably, before Game 4 had even been played, Jazz forward Al Jefferson commented that he didn't think any team would defeat the Spurs^[10] In Game 4, it seemed like the Spurs would complete the sweep when they had a 21-point lead. However, the Jazz eventually cut the lead to just 4 with 49.4 seconds left in the fourth. However, Tony Parker and Manu Ginóbili eventually sealed the series by stealing the ball and scoring on a basket respectively. The Spurs eventually completed the sweep, winning Game 4 by 6.

Regular-season series

This was the fifth playoff meeting between these two teams, with the Jazz winning three of the first four meetings.

(2) Oklahoma City Thunder vs. (7) Dallas Mavericks

The Mavericks came into the playoffs only as the 7th-seed, one of the lowest placements for a defending champion. Game 1 was a very close affair, with both teams going back and forth in the final minutes of the fourth quarter. However, Kevin Durant scored on a one-handed jumper with just about 1 second remaining. The Mavs still tried to win but Shawn Marion failed to get a shot off at the buzzer, giving the Thunder a one-point victory and a 1–0 series lead. Game 2 was also a close one but the Thunder held on and managed to squeak a 102–99 win and 2–0 series lead over the defending champs. In Game 3, the Mavs were no match for the Thunder, with the Thunder eventually blowing out the defending champs 95–79 to send the Mavs into the brink of a sweep. In Game 4, it looked as if the Mavs would stave off elimination when they led by 13 at the end of the third quarter. However, the Thunder outscored the Mavs 35–16 in the fourth and held on for a 103–97 victory over the Mavs. Following the sweep, the Mavs became just the 3rd defending champion to be swept in the first round.

Regular-season series

This was the fourth playoff meeting between these two teams, with the Mavericks winning two of the first three meetings.

(3) Los Angeles Lakers vs. (6) Denver Nuggets

The Lakers won the opening game 103–88 after Andrew Bynum had a triple-double with 10 points, 13 rebounds, and 10 blocked shots. The blocked shots broke Kareem Abdul-Jabbar's franchise record of nine, and tied the NBA playoff record set by Mark Eaton and Hakeem Olajuwon. Kobe Bryant scored 31 points and Pau Gasol added 13 points, eight rebounds and eight assists.^[13] The Lakers then won a close Game 2 but the Nuggets proceeded to blow out the Lakers in Game 3 99–84 to prevent the Lakers from taking a commanding 3–0 lead. Game 4 was close but Sessions and Blake hit pivotal 3's to put the Lakers in the lead for good and take a 3–1 series lead. Before Game 5, Bynum said that "Close-out games are actually kind of easy."^[14] The Nuggets responded by taking Game 5 102–99. The game saw the Lakers erase a 90–75 deficit with 6:35 left in the fourth quarter. In Game 6, Bryant played despite having a stomach illness, but still managed to score 31 points. However, with little contribution from Gasol and Bynum, the Nuggets forced Game 7 with a 113–96 blowout win over the Lakers. The Lakers won the series 4–3, and avoided becoming the ninth team in NBA history to be eliminated after blowing a 3–1 series lead. Gasol had 23 points, 17 rebounds and six assists, Bynum had 16 points and a playoff career-high 18 rebounds, and Steve Blake scored a playoff career-high 19 points in a 96–87 win in Game 7. The Lakers blew a 16-point lead in the second half before Gasol put the Lakers ahead for good with a tip-in basket with 6:30 left. Kobe Bryant sealed Denver's fate by hitting a 3 with 48.3 seconds left to put the Lakers up 8. Denver had 19 turnovers in the game and shot just 7-of-27 in the fourth quarter. Returning from his seven-game suspension, Metta World Peace scored 15 points, while Bryant had 17 points, and 8 assists.^[15]

Regular-season series

This was the sixth playoff meeting between these two teams, with the Lakers winning the first five meetings.

(4) Memphis Grizzlies vs. (5) Los Angeles Clippers

The Clippers rallied to win Game 1 in one of the largest comebacks in playoff history. Trailing by as many as 27, and down 95–71 with 9:13 left, the Clippers held the Grizzlies to just one field goal the rest of the game and pulled off an improbable 99–98 victory before a stunned, sold-out crowd of 18,119 at FedExForum.^[17] In Game 2, the Grizzlies avenged their embarrassing Game 1 loss by winning a close Game 2 to even the series going to Los Angeles. In Game 3, the Clippers survived a late Grizzlies rally in the final minute as Rudy Gay's 3 missed at the buzzer to give the Clippers an 87–86 victory and a 2–1 series lead. Game 4 was close, with the game going to overtime. With Chris Paul's heroics, the Clippers managed to win Game 4 and take a commanding 3–1 series lead. Back at home for Game 5, the Grizzlies tried to stave off elimination, at one point taking a 24-point lead in the third before the Clippers cut the lead again. However, the Grizzlies made sure there would be no collapse, using a 7–1 run in the final 1:44 to win Game 5 92–80. Facing elimination on the road, the Grizzlies gathered themselves, storming back from an eight-point fourth-quarter deficit to win Game 6 90–88, to force a decisive Game 7. In Game 7, the Clipper bench outscored their Grizzlies counterparts, 41–11, and it was enough as the Clippers won on the road, becoming the 6th NBA road team to do so after leading series 3–1, to advance to the semifinals against the Spurs.

Regular-season series

This was the first playoff meeting between the Clippers and the Grizzlies.^[18]

(2) Miami Heat vs. (3) Indiana Pacers

Even though the Heat won the regular season series, 3–1, this playoff series was expected to be a close one. In Game 1, the Heat took a major blow when Chris Bosh got injured in the first half. He was expected to be out for the rest of the series. However, James and Wade took over in the second half to give the Heat the win, 95–86. In Game 2, the Heat started strong, at one point taking a 9-point lead. The Pacers answered that by outscoring the Heat 28–14 in the third quarter to take an 11-point lead going to the fourth quarter. The Heat would come back, taking a 72–71 lead with 4:11 to go. However, with James and Wade missing key chances, the Pacers tied the series with a 78–75 win. Game 3 marked one of the worst playoff games for Wade, as he scored just 5 points on 2-of-13 shooting. Without Wade's contribution, the Heat found themselves down in the series 2–1 as the Pacers blew out the Heat, 94–75. Before Game 4, the Heat regrouped and refocused on the series. The result was a 101–93 victory over the Pacers in Game 4 to tie the series at 2–2. James scored 40 in the game, to go along with 18 rebounds and 9 assists. Wade recovered from his Game 3 performance by scoring 30. In Game 5, it was the Pacers who took the major blow when Danny Granger got injured in the second quarter by stepping on James's foot. He tried to come back in the third quarter but he aggravated his injury after fouling James. Then, after the third period, West left the game with a knee injury. Without Granger and West, the Pacers were unable to stop the Heat, as the Heat won 115–83 to take a 3–2 series lead, putting them a win away from the Eastern Conference Finals. In Game 6, West and Granger started for the Pacers despite their injuries. The Pacers started strong, even taking a 19–8 lead in the first quarter. However, the third quarter was decisive, with the Heat outscoring the Pacers 28–16 to take a 79–69 lead going to the fourth quarter. Led by Wade's 41 and James's 28, the Heat won three straight, 105–93, to take the series, 4–2.

Regular-season series

This was the second playoff meeting between these two teams, with the Pacers winning the first meeting.

(5) Boston Celtics vs. (8) Philadelphia 76ers

The Sixers came off fresh of an upset over the injury-laden Bulls. Both the Celtics and the Sixers clinched their first round series on the same day. In Game 1, Rondo had another triple-double, but the Sixers held a 10-point lead with 10:53 left in the fourth quarter. However, the Celtics eventually came back, winning Game 1 by a point to take a 1–0 series lead. On the final possession, the Sixers were unable to foul a speedy Rondo, who dribbled out the clock. Game 2 saw the visitors lead for most of the game. With the Sixers leading 78–75 with 12 seconds to go, the Celtics squandered a chance to tie the game, as Garnett was called for an offensive foul. The Sixers then hit their final four free-throws to tie the series at 1 going back to Philadelphia. In Game 3, the Sixers held their last lead with 9:09 left in the second quarter as the Celtics took over the rest of the game to lead them to a 2–1 series advantage. In Game 4, the Celtics led by as much as 18 in the third quarter. Facing the prospect of trailing 1–3 in the series, the Sixers came back to take the game from the Celtics and tie the series going back to Boston. Game 5 saw Brandon Bass score 27 points, including 18 in the third quarter as the Celtics blew out the Sixers, 101–85, to push them a win away from the Eastern Conference Finals. Before the start of Game 6, Allen Iverson presented the game ball, prompting huge cheers from the crowd. It was enough to motivate the Sixers to defeat the Celtics 82–75 to force a Game 7. Jrue Holiday scored 20 points, including two free-throws with 31 seconds to go to put the game away. Game 7 was a tight contest, with the two teams going back-and-forth. Paul Pierce fouled out late in the fourth quarter, but Rondo had his second triple-double of the series, including a fourth quarter that helped the Celtics advance to the Conference Finals to face the Miami Heat.

This series is an important plot point in the 2019 film Uncut Gems, in which Garnett co-stars.^[20]

Regular-season series

This was the 20th playoff meeting between these two teams, with the Celtics winning 11 of the first 19 meetings.

(1) San Antonio Spurs vs. (5) Los Angeles Clippers

The Spurs won their last 14 games coming into this series. They were also well prepared because they were able to sweep their previous opponent, the Utah Jazz. Meanwhile, the Clippers were coming off a tough seven-game series against the Memphis Grizzlies and had to play Game 1 just 2 days after the Game 7 ended. Game 1 was close as the teams were tied coming into the 2nd quarter. However, the Spurs quickly took control in the 2nd and 3rd quarters as they defeated the Clippers, 108–92, and took a 1–0 series lead. Game 2 then saw a Spurs team taking control in the second half to defeat the Clippers and take a 2–0 lead. Going to Los Angeles for a back-to-back Games 3 and 4, the Clippers looked confident to defeat the Spurs, as they quickly took a 40–16 lead with 9:17 to go in the 2nd. However, the Spurs quickly cut the lead to 7 with 36.4 seconds before the half, with the half ending with a 10-point Clipper lead. Then, with the Clippers holding on to a 12-point lead with 9:39 to go in the 3rd, the Spurs unleashed a ferocious 24–0 run to take a 69–57 lead with 2 minutes to go in the 3rd. The Clippers never got closer than seven down the stretch as they watched the Spurs take a commanding 3–0 lead in the series. Game 4 was a close one, with the Clippers leading for much of the fourth quarter before the Spurs took the lead on a Duncan hook shot. Then, in the final moments of the game, Paul made several mistakes, a bad pass and an off-balanced jump shot that missed, that ultimately led to Clippers' demise. Following Parker's free-throw that extended the Spurs' lead to 3, the Clippers had one last chance. However, out of timeouts, the Clippers were forced to take a long inbound pass. Mo Williams managed to catch the ball but was unable to get a shot off as the Spurs completed the sweep of the Clippers. The Spurs became just the fourth team to go 8–0 through the first two rounds of the playoffs.

Regular-season series