Derived from the original story Marcelino Pan y Vino, this is a story of a boy who was adopted by priests in a monastery. Marcelino (Bryan Homecillo) would often run to the only friend he thinks he has, the man crucified at the cross.

The town's people to whom Dr. Jose Cruses (Paolo Bediones) has given medical services at no cost, felt terrified when they saw the dead body of the doctor, together with two more corpses of prisoners near the city jail. Dr. Cruses has been an instrument for the people of the town to face their fears and fight for their rights from the cruel town's governor.

A story about loss, acceptance and faith, Oliver (Dennis Trillo) is a teacher and a family man who is expecting his second child soon. Jomari (Phytos Ramirez) is a loving child and brother to his parents and sister. These two will cross paths and will draw strength from each other upon experiencing a devastating storm that took the lives of their families and several people within their community.

Arman's (Cesar Montano) hands are capable of healing what seems to be impossible, a gift the whole town believes to be given by God. Both married, Arman and Belen had an affair and unfortunately, Belen (Sunshine Cruz) became pregnant. To protect his reputation, Arman insisted for abortion which led to several unfortunate events to the both of them.

Luke (Dennis Trillo), Mayor Eusebio's (Eddie Garcia) unico hijo, became the town's subject of interest for his being transsexual. He added up to the problems of his father’s upcoming campaign as claimed by many. Criticisms surrounded the family but Mayor Eusebio accepted his unico hijo with all his heart despite all the pains and disappointments he had caused him.

Ellen (Lorna Tolentino) faces the trials of going back to normal life after being sentenced to ten years in prison. Her husband Rodel (Nonie Buencamino) never left her side. But her children hardly know her because of Amparo (Shamaine Buencamino), Rodel’s sister, who took over Ellen’s role as mother while she was behind bars.

Torn between her duty to an abusive husband and selfless devotion to a mentally retarded friend named Sonny (Dennis Trillo), Hilda (Marian Rivera) hesitantly allows him to stay in her home and take care of him. Aldo (Gardo Versoza) accuses Hilda of having an illicit affair with Sonny and he relentlessly beats Hilda. The witness of this violence triggers Sonny’s memory of a very traumatic childhood.

On the road together with a friend one day, Marita (Glydel Mercado) accidentally hits a woman crossing the street. Her name is Teresa (Marian Rivera). The victim has been injured and unconscious so they decided to bring her home and let her stay there together with Marita's husband and children until she feels better. Teresa told them she was an angel but no one believes her. Teresa's stay with them slowly transformed Marita's broken household to a happy one. They were nearly convinced that she is indeed a heaven-sent angel until a tragedy happened.

Eloisa (Agot Isidro) is a widow. She spends most of her time raising her child, teaching at a public school and supporting her siblings. In the middle of her son Kiko's (Rocco Nacino) campaign, an accident happened and Martin (Dennis Trillo), the school janitor, would see the incident and would immediately rescue. With Eloisa's great gratitude, she became close to Martin. And the two started to have a relationship that would bring unexpected complications in their lives.

Having survived miraculously from an accident that claimed the lives of her parents, Claire (Lovi Poe) decides to become a nun and devote her life to God. She is devastated, however, when she had to leave the convent due to poor health. She settles down to a quiet life in a small town, regularly serving as a volunteer at her local church. Unexpectedly, Claire finds love in the person of Edgar (James Blanco). However, just as they are planning to get wed, Claire starts seeing visions and experiences strange physical sensations, until one day she wakes up with stigmata wounds on her hands. She eventually attracts a lot of attention and this, in time, isolates Edgar and causes embarrassment among his very conservative family. Now, Claire must choose between personal happiness and fulfilling God's call for her life.

Perpetua (Susan Roces), a young novice, was named after Our Lady of Perpetual Help. She was brought up by her religious mother, and was made to believe that a life in the convent was best for her. However, after merely two years as a postulant, she suddenly falls in love with Agustin (Lito Legaspi). Perpetua chooses to leave the convent and marry Agustin. She seemed to have made the right choice as heaven still seems to be showering her family with unending blessings. On Perpetua and Agustin’s 50th wedding anniversary, she discovers that Agustin actually has another wife — Adelaida (Boots Anson-Roa), whom he married long before he married Perpetua. This event causes her family to fall apart. And now she starts to question: Did heaven really shower her blessings, or was heaven just waiting for the right time to punish her for choosing love over spiritual vocation?

Life seemed perfect for Lauren (Marian Rivera) — a fulfilling job, happy family, and an upcoming wedding. But some good things don’t last. Tragedy struck as super typhoon Yolanda claimed the lives of her loved ones. Lauren feels she should have died along with them and immensely feels the tragic loss. Fate leads her to a young girl named Gelay (Angeli Nicole Sanoy) who seemed to embody the promises of life in her “bucket list.” Building another relationship wasn’t easy for Lauren, but Gelay eventually made her believe that there’s a silver lining at the end of the rainbow. Life almost seemed to become normal and happy again for Lauren. Until one day, she discovers that Gelay is terminally ill, hence she has a bucket list. How can Lauren appreciate the beauty of living life, if she is bound to lose the only person she has now?

Brotherhood has never been smooth for Sam (Alden Richards) and Onyok (Paolo Ballesteros) as they have always disdained each other. In the turn of events, Sam was told that their mother was hospitalized. He had no choice but to bring his brother back home. But in a more trying twist of fate, Sam discovers that Onyok has taken a different path that is even harder to accept - to become a woman and change his name to Sophia. How will Sam and Sophia come to terms with their seemingly irreconcilable differences as siblings?

What started out as the bride's accidental dropping of a wine glass cast a dark shadow upon the seemingly perfect couple Jean (Jennylyn Mercado) and Martin (Tom Rodriguez). Jean is diagnosed with a medical condition known as Amyotrophic Lateral Sclerosis (ALS) which has become too aggressive for her to deal with alone. She starts to conceal her physical difficulties by being hostile to the people who cares about her. How will Jean and Martin deal with a crippling disease that threatens not only to debilitate Jean, but eventually destroy her relationship with Martin?

For a prisoner like Argel "Boy Pitik" Corpus (Dingdong Dantes), hoping is futile. He was a lookout in a bank robbery that ended up in a chilling loss of innocent lives. He has become aloof, and unlike the other detainees, he never had any visitor. Argel religiously dials 1430 and pretends to be talking to a person on the other line. In reality, it's just a dial tone. But one day, someone suddenly speaks on the other end of the line. How can one voice spark change and hope in the life of a convicted criminal?

Spirits are believed to roam around in limbo as they seek to close unfinished business, to finally walk into the light, to move on. But what if they're bound in this plane because it's the living that can't move on? A fake seer who has no love for anything and anyone but her sister gets a run for her money when she wakes up one day and sees ghosts for real. Seeking to close her 'eye', she and her sister help the spirits move on while learning to let go of her living ghosts too — her anger for their father, her grief with the loss of her mother, her lack of faith. Follow the story of the two sisters as they toe the line between the living and the dead, how they find redemption in love, and how they find God in the midst of pain.