Mdluli is an African surname that may refer to
- John Mdluli (born 1972), Swaziland football player
- Labotsibeni Mdluli (c.1859–1925), Queen Mother and Queen Regent of Swaziland
- Mlungisi Mdluli (born 1980), South African football midfielder
- Richard Mdluli (born 1958), head of Police Crime Intelligence in South Africa
- Siyabonga Mdluli (born 1986), Swaziland football player
- K.O (rapper) (born Ntokozo Mdluli), South African rapper
- Pat Mdluli (born 1989) a South African humanitarian
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