Man's best friend is a common phrase about domestic dogs.

Man's best friend may also refer to:

• The domestic dog

Film and television

• Man's Best Friend (1935 film), a feature film about the adventures of a boy and his dog
• Man's Best Friend (1952 film), a cartoon short starring Goofy
• Man's Best Friend (1993 film), a black comedy horror movie
• "Man's Best Friend" (The Ren & Stimpy Show), an unaired episode of The Ren & Stimpy Show

Music and literature

• Man's Best Friend (album), a 1980 album by Livingston Taylor
• Man's Best Friend (manga), a 2006 Japanese sex comic
• Man’s Best Friend, a 2021 EP by Cavetown
• Mansbestfriend, a series of albums by Sole
• "Man's Best Friend", a 1993 song by Jeff Watson from Around the Sun
• "Man's Best Friend", a 2019 song by Nebula from Holy Shit