MTFMT

MTFMT
Identifiers
Aliases	MTFMT, COXPD15, FMT1, mitochondrial methionyl-tRNA formyltransferase, MC1DN27
External IDs	OMIM: 611766 MGI: 1916856 HomoloGene: 12320 GeneCards: MTFMT
Gene location (Human)
Chr.	Chromosome 15 (human)
End	65,029,639 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,360,336 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; stromal cell of endometrium; ; left uterine tube; ; gastric mucosa; ; rectum; ; canal of the cervix; ; smooth muscle tissue; ; right ventricle; ; islet of Langerhans; ; left coronary artery;
	Top expressed in
	medullary collecting duct; ; proximal tubule; ; renal corpuscle; ; secondary oocyte; ; yolk sac; ; spermatocyte; ; thymus; ; left lobe of liver; ; lens; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; hydroxymethyl-, formyl- and related transferase activity; catalytic activity; methionyl-tRNA formyltransferase activity;
Cellular component	mitochondrion;
Biological process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA; biosynthesis; protein biosynthesis; translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	123263
	69606
	ENSG00000103707
	ENSMUSG00000059183
	Q96DP5
	Q9D799
	NM_139242
	NM_027134
	NP_640335
	NP_081410
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial methionyl-tRNA formyltransferase is a protein that in humans is encoded by the MTFMT gene.^[5]

The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA.^[5] Recessive-type mutations in MTFMT have been shown to cause mitochondrial disease.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000103707 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059183 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Mitochondrial methionyl-tRNA formyltransferase". Retrieved 2011-09-20.
↑ Tucker, E. J.; Hershman, S. G.; Köhrer, C.; Belcher-Timme, C. A.; Patel, J.; Goldberger, O. A.; Christodoulou, J.; Silberstein, J. M.; McKenzie, M.; Ryan, M. T.; Compton, A. G.; Jaffe, J. D.; Carr, S. A.; Calvo, S. E.; Rajbhandary, U. L.; Thorburn, D. R.; Mootha, V. K. (2011). "Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation". Cell Metabolism. 14 (3): 428–434. doi:10.1016/j.cmet.2011.07.010. PMC 3486727. PMID 21907147.

References

Further reading